SavedAdd your journal

Journals / Akademik Acil Tıp Dergisi / 2012 / Cilt: 11 - Sayı: 4

Kreatin kinaz düzeyi yüksek olan hastalarda heart fatty acid binding protein hatalı olarak pozitif olabilir

Possible false positive heart fatty acid binding protein in patient who has a high level of creatinine kinase

Mehmet KANADAŞI
Nihat SÖYLEMEZ
Ayça AÇIKALIN
Pages
241–242
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Recently, we have observed 3 patients who had high CK levels due to destruction of skeletal muscle and they had false positive high H-FABP levels. (JAEM 2012; 11: 241-2)

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Serum heart fatty acid binding protein (H-FABP) is a novel sensitive marker for early diagnosis of acute myocardial infarction.
📊
Key Findings & Data:However, H-FABP is less specific than troponins, because it is also found in skeletal muscle.
💡
Conclusion & Impact:Recently, we have observed 3 patients who had high CK levels due to destruction of skeletal muscle and they had false positive high H-FABP levels. (JAEM 2012; 11: 241-2)
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Serum heart fatty acid binding protein (H-FABP) is a novel sensitive marker for early diagnosis of acute myocardial infarction. However, H-FABP is less specific than troponins, because it is also found in skeletal muscle. Recently, we have observed 3 patients who had high CK levels due to destruction of skeletal muscle and they had false positive high H-FABP levels. (JAEM 2012; 11: 241-2)

Özet

Heart fatty acite binding protein (H-FABP) erken dönemde akut miyokard enfarktüsünü gösteren yeni hassas bir belirteçtir. Troponin’den daha az özgüldür, çünkü ayrıca iskelet kasında da bulunur. Son zamanlarda iskelet kası yıkımına bağlı CK yüksekliği bulunan ve beraberinde hatalı pozitif H-FABP yüksekliği saptanan 3 hasta gözlemledik. (JAEM 2012; 11: 241-2)

🔖

Cite This Article

KANADAŞI, M., SÖYLEMEZ, N., AÇIKALIN, A. (2022). Kreatin kinaz düzeyi yüksek olan hastalarda heart fatty acid binding protein hatalı olarak pozitif olabilir. Akademik Acil Tıp Dergisi, Cilt: 11 - Sayı: 4, 241–242. https://ajindex.com/articles/431658

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Tanaka T, Hirota Y, Sohmiya K, Nishimura S, Kawamura K. Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction. Clin Biochem 1991
  2. [CrossRef] 2. Glatz JF, van der Vusse GJ, Simoons ML, Kragten JA, van Dieijen-Visser MP, Hermens WT. Fatty acid-binding protein and the early detection of acute myocardial infarction. Clin Chim Acta 1998
  3. [CrossRef] 3. Okamoto F, Sohmiya K, Ohkaru Y, Kawamura K, Asayama K, Kimura H, et al. Human heart-type cytoplasmic fatty acid-binding protein (H-FABP) for the diagnosis of acute myocardial infarction: clinical evaluation of HFABP in comparison with myoglobin and creatine kinase isoenzyme MB. Clin Chem Lab Med 2000
  4. [CrossRef] 4. Ishii J, Wang JH, Naruse H, Taga S, Kinoshita M, Kurokawa H, et al. Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction. Clin Chem 1997
  5. [CrossRef] 5. Seino Y, Ogata K, Takano T, Ishii J, Hishida H, Morita H, et al. Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: comparison with rapid troponin T and myoglobin tests. Am J Med 2003
  6. [CrossRef] 6. Van Nieuwenhoven FA, Kleine AH, Wodzig WH, Hermens WT, Kragten HA, Maessen JG, et al. Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein. Circulation 1995
  7. Watanabe T, Ohkubo Y, Matsuoka H, Kimura H, Sakai Y, Ohkaru Y, et al. Development of a simple whole blood panel test for detection of human heart-type fatty acid-binding protein. Clin Biochem 2001
  8. [CrossRef] 8. Tsuji R, Tanaka T, Sohmiya K, Hirota Y, Yoshimoto K, Kinoshita K, et al. Human heart-type cytoplasmic fatty acid-binding protein in serum and urine during hyperacute myocardial infarction. Int J Cardiol 1993
  9. [CrossRef] 9. Ohkaru Y, Asayama K, Ishii H, Nishimura S, Sunahara N, Tanaka T, et al. Development of a sandwich enzyme-linked immunosorbent assay for the determination of human heart-type fatty acid-binding protein in plasma and urine by using two different monoclonal antibodies specific for human heart-type fatty acid-binding protein. J Immunol Methods 1995
  10. [CrossRef] 10. Katus HA, Remppis A, Neumann FJ, Scheffold T, Diederich KW, Vinar G, et al. Diagnostic efficiency of troponin T measurements in acute myocardia