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Journals / Acta Medica / 2022 / Cilt: 53 - Sayı: 2

A Review of Glutamate and Its Receptors: Their Roles in Brain Physiology and Pathology

Sevgi UĞUR MUTLUAY
Hülya KARATAŞ
Pages
99–109
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This opinion aims to summarize the cellular mechanism that lead to pathology and review how these mechanisms translate into the clinic.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Glutamate is the most abundant excitatory neurotransmitter in the central nervous system.
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Key Findings & Data:Through its ionotropic and metabotropic receptors it mediates both fast transmission and long term metabolic changes in a cell.
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Conclusion & Impact:This opinion aims to summarize the cellular mechanism that lead to pathology and review how these mechanisms translate into the clinic.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Glutamate is the most abundant excitatory neurotransmitter in the central nervous system. Through its ionotropic and metabotropic receptors it mediates both fast transmission and long term metabolic changes in a cell. Besides neurotransmission, it takes part in development of central nervous system, cell energy metabolism and synaptic plasticity processes. Glutamatergic signaling is strictly controlled. Under normal conditions, extrasynaptic gluatamate levels are maintained at low concentrations. Excessive transmission leads to excitotoxicity which results in cell damage and death. Glutamatergic dysfunction is involved in many pathologies including neuropsychiatric, neurodegenerative and neurodevelopmental disorders. Impairments in glutamate’s physiological functions, excitotoxicity and disrupted modulation of other neurotranmitter systems contribute to these pathologies. This opinion aims to summarize the cellular mechanism that lead to pathology and review how these mechanisms translate into the clinic.

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Cite This Article

MUTLUAY, S. U., KARATAŞ, H. (2022). A Review of Glutamate and Its Receptors: Their Roles in Brain Physiology and Pathology. Acta Medica, Cilt: 53 - Sayı: 2, 99–109. https://ajindex.com/articles/427517

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References (15)

  1. Hassel B, Dingledine R. Glutamate and Glutamate Receptors. In: Brady ST, Siegel GJ, Albers RW, Price DL (eds). Basic Neurochemistry. Eighth Edition. Elsevier, 2012; 342- 366
  2. Schousboe A. A Tribute to Mary C. McKenna: Glutamate as Energy Substrate and Neurotransmitter—Functional Interaction Between Neurons and Astrocytes. Neurochem Res 42, 4–9 (2017). https://doi.org/10.1007/s11064-015- 1813-9 [3] Magi S, Piccirillo S, Amoroso S. The dual face of glutamate: from a neurotoxin to a potential survival factor— metabolic implications in health and disease. Cell Mol Life Sci. 2019;76(8):1473-1488
  3. Watkins, JC, Jane, DE. The glutamate story. Br J Pharmacol. 2006; Vol. 147 (Suppl 1): S100 - S108
  4. Miladinovic T, Nashed MG, Singh G. Overview of glutamatergic dysregulation in central pathologies. Biomolecules. 2015;5(4):3112-3141
  5. Luján R, Shigemoto R, López-Bendito G. Glutamate and GABA receptor signalling in the developing brain. Neuroscience. 2005;130(3): 567-580
  6. Barker-Haliski M, Steve White H. Glutamatergic mechanisms associated with seizures and epilepsy. Cold Spring Harb Perspect Med. 2015;5(8):1-15
  7. Zhang Z, Zhang S, Fu P, et al. Roles of glutamate receptors in Parkinson’s disease. Int J Mol Sci. 2019; 20(18):4391
  8. Balkhi HM, Gul T, Banday Z, Haq E. “ Glutamate Excitotoxicity: An Insight into the Mechanism “. Int J Adv Res Journalwww.journalijar.com Int J Adv Res. 2014;2(7): 361-373
  9. Crupi R, Impellizzeri D, Cuzzocrea S. Role of metabotropic glutamate receptors in neurological disorders. Front Mol Neurosci. 2019;12(February):1-11
  10. Murrough JW, Abdallah CG, Mathew SJ. Targeting glutamate signalling in depression: Progress and prospects. Nat Rev Drug Discov. 2017;16(7):472-486
  11. Campos-Pea V, Antonio M. Alzheimer Disease: The Role of Aβ in the Glutamatergic System. In: Heinbockel T (ed.) Neurochemistry. InTechOpen, 2014
  12. Watts ME, Pocock R, Claudianos C. Brain energy and oxygen metabolism: Emerging role in normal function and disease. Front Mol Neurosci. 2018;11(June):1-13
  13. Cooper AJL, Jeitner TM. Central role of glutamate metabolism in the maintenance of nitrogen homeostasis in normal and hyperammonemic brain. Biomolecules. 2016; 6(2):16
  14. Jansson LC, Åkerman KE. The role of glutamate and its receptors in the proliferation, migration, differentiation and survival of neural progenitor cells. J Neural Transm. 2014;121(8):819-836
  15. Berg DA, Belnoue L, Song H, Simon A. Neurotransmittermediated contr