Journals / Abant Tıp Dergisi / 2014 / Cilt: 3 - Sayı: 1

Narrow - band UVB treatment in generalized lichen planus

Jeneralize liken planusta dar -bant UVB tedavisi

Pages
12–15
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion : Narrow -band UVB phototherapy is an effectiveand safe treatment modality in the treatment of generalizedLP.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective : Lichen planus (LP) is a common inflammatory skindisease.
📊
Key Findings & Data:Method : In our study, the data of the patients with LP whowere treated in our c linic s phototherapy unit from betweenJanuary 2009 and December 2012 were analyzedretrospectively.
💡
Conclusion & Impact:Conclusion : Narrow -band UVB phototherapy is an effectiveand safe treatment modality in the treatment of generalizedLP.
🔬Design:Research Article
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective : Lichen planus (LP) is a common inflammatory skindisease. Recently, narrow-band ultraviolet B (UVB)phototherapy has been re ported to be effective in thetreatment of LP. In this study, we aimed to evaluate theefficacy and safety of the narrow -band UVB phototherapy inpatients with generalized LP. Method : In our study, the data of the patients with LP whowere treated in our c linic s phototherapy unit from betweenJanuary 2009 and December 2012 were analyzedretrospectively. Clinical response was named as "completeresponse , "partial response , "poor response or noresponse when the improvement of the lesions is 90% andhig her, 51 -89%, 21 -50% and below 20%, respectively. Results : The study included 20 patients between the ages of 9 - 71. Duration of disease of the patients ranged from 1 -84months and 30% of the patients had an additional systemicdisease. Twelve patients had c omplete response (60%), fivepatients (25%) had partial response, and one patient had littleresponse (10%) but the response to treatment could not beobtained in two patients (5%). The mean total number ofsessions was 45.2 ± 16.4 (18 -80) and the mean tot alcumulative dose was 54.6 ± 34.2 J/cm 2. Clinical completeresponse was obtained at average 37.7 (24 -50) sessions. Acuteside effects of phototherapy were observed only in threepatients. Conclusion : Narrow -band UVB phototherapy is an effectiveand safe treatment modality in the treatment of generalizedLP.

Özet

Amaç: Liken planus (LP) sık görülen inflamatuar bir derihastalığıdır. Son zamanlarda dar-bant ultraviyole B (UVB)fototerapisinin LP tedavisinde etkili olduğubildirilmektedir. Bu çalışmada jeneralize LPli hastalardadar-bant UVB tedavisinin etkinliği ve güvenilirliğinindeğerlendirilmesi amaçlanmıştır.Yöntem : Çalışmamızda Ocak 2009 ve Aralık 2012 tarihleriarasında kliniğimiz fototerapi ünitesinde LP tanısı iletedavi gören hastalara ait veriler retrospektif olarakincelendi. Klinik yanıt, sırasıyla lezyonlardaki iyileşme % 90ve üzerinde, 51 -89%, 21 -50% ve % 20'nin altındaolduğunda, "tam yanıt", "kısmi yanıt", "az yanıt" ya da"yanıt yok" olarak adlandırıldı.Bulgular: Çalışmaya 9 -71 yaş arasında 20 hasta alındı.Hastaların hastalık süreleri 1 -84 ay arasında değişmekteydive hastaların %30unun ek bir sistemik hastalığı vardı. Oniki hastada (%60) tam yanıt, beş hastada (%25) kısmi yanıt,bir hastada (%5) az yanıt saptandı ancak iki hastada (%10)tedaviye yanıt elde edilemedi. Total seans sayısıortalaması 45,2 ± 16,4 (18 -80) ve total kümülatif dozortalaması 54,6 ± 34,2 J/cm 2olarak belirlendi. Klinik tamyanıt ortalama 37,7 (24 -50) seansta elde edildi.Fototerapiye bağlı akut yan etkiler sadece üç hastadaizlendi.Sonuç : Dar-bant UVB fototerapisi, jeneralize LPtedavisinde etkili ve güvenilir bir tedavi yöntemidir.

🔖

Cite This Article

DOĞRAMACI, A. Ç., ÇELİK, E., EKİZ, Ö., RİFAİOĞLU, E. N., BÜLBÜLŞEN, B., ŞEN, T. (2022). Narrow - band UVB treatment in generalized lichen planus. Abant Tıp Dergisi, Cilt: 3 - Sayı: 1, 12–15. https://ajindex.com/articles/427120

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Pittelkow MR, Daoud MS: Lichen Planus. Fitzpatricks’s Dermatology in General Medicine. Ed. Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell D J. 7th eds. New York, McGraw-Hill, 2008;244- 55
  2. Taneja A, Taylor C: Narrow -band UVB for lichen planus treatment. Int J Dermatol 2002;41:282 -3
  3. Sarıcaoglu H, Karadogan SK, Baskan EB, Tunali S: Narrowband UVB therapy in the treatment of lichen planus. Photodermatol Photoimmunol Photomed 2003;19:265 -7
  4. Habib F, Stoebner PE, Picot E: Narrow band UVB photo therapy in the treatment of widespread lichen planus. Ann Dermatol Venereol 2005;132:17-20
  5. Pavlotsky F, Nathansohn N, Kriger G, Shpiro D, Trau H: Ultraviolet- B treatment for cutaneous lichen planus: our experience with 50 patients. Photodermatol Photoimmunol Photomed 2008;24:83 -6
  6. Gamil H, Nassar A, Saadawi A, El-Qashishi K, Ahmed F: Narrow -band ultraviolet B phototherapy in lichen planus. J Eur Acad Dermatol Venereol 2009;23:589-90
  7. Yamamoto T, Osaki T: Characteristic cytokines generated by keratinocytes and mononuclear infiltrates in oral lichen planus. J Invest Dermatol 1995;104:784-8
  8. Krutmann J, Morita A, Elmets A: Mechanisms of photo(chemo)therapy. Dermatological Phototherapy and Photodiagnostic Methods. Ed. Krutmann J, Honigsmann H, Elmets CA, Bergstresser PR. Berlin, Springer, 2001;56-9
  9. Sigmundsdottir H, Johnston A, Gudjonsson JE, Valdimarsson H: Narrowband -UVB irradiation decreases the production of pro -inflammatory cytokines by stimulated T cells. Arch Dermatol Res. 2005;297:39-42
  10. Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I: Immunosuppressive effects of apoptotic cells. Nature 1997;390:350-1.