SavedAdd your journal

Journals / Zeynep Kamil medical journal (Online) / 2021 / Cilt: 52 - Sayı: 2

Acute dystonia after domperidone use: A rare and an unexpected side effect

Salih DEMİRHAN
Özlem ERDEDE
Rabia Gönül SEZER YAMANEL
Pages
109–111
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

To the best of our knowledge, our case is the first case report in children who were successfully and rapidly treated with anticholinergic, biperiden.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Domperidone is a dopamine receptor antagonist with gastrokinetic and anti-emetic effects.
📊
Key Findings & Data:Herein, we reported a 12-year-old girl who presented with dystonia after domperidone usage.
💡
Conclusion & Impact:To the best of our knowledge, our case is the first case report in children who were successfully and rapidly treated with anticholinergic, biperiden.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Domperidone is a dopamine receptor antagonist with gastrokinetic and anti-emetic effects. Domperidone is widely used worldwide as an anti-emetic and in the treatment of gastroparesis and gastroesophageal reflux. Because domperidone does not readily cross the blood-brain barrier, central nervous system side effects are not expected. Herein, we reported a 12-year-old girl who presented with dystonia after domperidone usage. We present a 12-year-old girl with a 40 kg body weight who was admitted to our pediatric emergency department with numbness, stiffness, and twisting in the neck, hands, arms, and tingling in the legs and back. We administered 3 mg biperiden, an anticholinergic, through slow intravenous infusion. The patient’s dystonic reaction recovered 10 min after biperiden infusion. Based on our literature search, we presented one of the few acute dystonia cases after domperidone use in children. To the best of our knowledge, our case is the first case report in children who were successfully and rapidly treated with anticholinergic, biperiden.

🔖

Cite This Article

DEMİRHAN, S., ERDEDE, Ö., YAMANEL, R. G. S. (2022). Acute dystonia after domperidone use: A rare and an unexpected side effect. Zeynep Kamil medical journal (Online), Cilt: 52 - Sayı: 2, 109–111. https://ajindex.com/articles/426179

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Barone JA. Domperidone: A peripherally acting dopamine2-receptor antagonist. Ann Pharmacother 1999;33(4):429–40
  2. Tonini M, Cipollina L, Poluzzi E, Crema F, Corazza GR, De Ponti F. Review article: Clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther 2004;19(4):379–90
  3. Mitchelson F. Pharmacological agents affecting emesis: A review (Part I). Drugs 1992;43(3):295–315
  4. Osborne RJ, Slevin ML, Hunter RW, Hamer J. Cardiotoxicity of intravenous domperidone. Lancet 1985;2(8451):385
  5. Doggrell SA, Hancox JC. Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine. Expert Opin Drug Saf 2014;13(1):131–8
  6. PRAC Recommends Restricting Use of Domperidone: European Medicines Agency; 2014. Available from: https://www.ema.europa.eu/en/ news/prac-recommends-restricting-use-domperidone
  7. Domperidone for Nausea and Vomiting: Lack of Efficacy in Children; Reminder of Contraindications in Adults and Adolescents United Kingdom: Medicines and Healthcare Products Regulatory Agency; 2019. Available from: https://www.gov.uk/drug-safety-update/domperidone-for-nausea-and -vomiting-lack-of-efficacy-in-children-reminder-of-contraindicationsin-adults-and-adolescents
  8. Schey R, Saadi M, Midani D, Roberts AC, Parupalli R, Parkman HP. Domperidone to treat symptoms of gastroparesis: Benefits and side effects from a large single-center cohort. Dig Dis Sci 2016;61(12):3545– 51
  9. Ortiz A, Cooper CJ, Alvarez A, Gomez Y, Sarosiek I, McCallum RW. Cardiovascular safety profile and clinical experience with high-dose domperidone therapy for nausea and vomiting. Am J Med Sci 2015;349(5):421– 4
  10. Debontridder O. Dystonic reactions after domperidone. Lancet 1980;2(8206):1259
  11. Bonuccelli U, Nocchiero A, Napolitano A, Paoletti AM, Melis GB, Corsini GU, et al. Domperidone-induced acute dystonia and polycystic ovary syndrome. Mov Disord 1991;6(1):79–81
  12. Roy-Desruisseaux J, Landry J, Bocti C, Tessier D, Hottin P, Trudel JF. Domperidone-induced tardive dyskinesia and withdrawal psychosis in an elderly woman with dementia. Ann Pharmacother 2011;45(9):e51
  13. Madej TH. Domperidone--an acute dystonic reaction. Anaesthesia 1985;40(2):202
  14. Dhakal OP, Dhakal M, Bhandari D. Domperidone-induced dystonia: A rare and troublesome complication. BMJ Case Rep 2014;2014:bcr2013200282
  15. Shahbaz A, Elahi K, Affan M, Shahid MF, Sabir A. Acute dystonia secondary t