Journals / Acta Medica Alanya / 2019 / Cilt: 3 - Sayı: 2

Structures of Cytoskeleton and Disease Interactions

Hücre İskeleti Yapıları ve Hastalıklarla Etkileşimleri

Pages
197–202
Publication Date
2022-09-04
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The nature of these structures isbriefly outlined and the literature review that is reporting relationship between cytoskeleton components and common disorders is presented in this paper.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Researchers reported different basics for different kind of diseases with advancedtechnology.
📊
Key Findings & Data:Meanwhile, investigators are focused on to clarify the interactions ofbasic cellular mechanisms recently.
💡
Conclusion & Impact:The nature of these structures isbriefly outlined and the literature review that is reporting relationship between cytoskeleton components and common disorders is presented in this paper.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Researchers reported different basics for different kind of diseases with advancedtechnology. Meanwhile, investigators are focused on to clarify the interactions ofbasic cellular mechanisms recently. Therefore, cytoskeletal researches are gain importance due to this tendency. The cytoskeletal structures are responsible for interconnects between cell nucleus, cytoplasm and also extracellular matrix, whereby itcreate a communication link between cellular molecules and signalization transport.The cytoskeleton is constructed from three kinds of protein filaments as: actin filaments, intermediate filaments, and microtubules. The nature of these structures isbriefly outlined and the literature review that is reporting relationship between cytoskeleton components and common disorders is presented in this paper.

Özet

Araştırmacılar, ileri teknolojiye sahip farklı hastalıklar için farklı temeller bildirmişlerdir. Bu arada, son zamanlarda temel hücresel mekanizmaların etkileşimlerini netleştirmek için birçok araştırma yapılmıştır. Bu nedenle, hücre iskeleti araştırmaları bu eğilim nedeniyle önem kazanmaktadır. Hücre iskeleti yapıları, hücre çekirdeği, sitoplazma ve ayrıca hücre dışı matriks arasındaki bağlantılardan sorumludur, böylece hücresel moleküller ve sinyalizasyon iletimi arasında bir iletişim bağlantısı oluşturur. Hücre iskeleti, üç çeşit protein filamanından oluşur: aktin filamentleri, ara filamentler ve mikrotübüller. Bu makalede, bu yapıların niteliği kısaca özetlenmiştir ve hücre iskeleti bileşenleri ile yaygın hastalıklar arasındaki ilişkiyi bildiren literatür taraması sunulmuştur.

🔖

Cite This Article

MELEKOĞLU, A., KARAHAN, O. (2022). Structures of Cytoskeleton and Disease Interactions. Acta Medica Alanya, Cilt: 3 - Sayı: 2, 197–202. https://ajindex.com/articles/425885

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Mandadapu KK, Govindjee S, Mofrad MR. On the cytoskeleton and soft glassy rheology. J Biomech. 2008;41(7):1467-78. doi: 10.1016/j.jbiomech.2008.02.014
  2. Mofrad MR. Rheology of the Cytoskeleton. Annual Review of Fluid Mechanics 2009;41: 433-453 3. Ramaekers FC, Bosman FT. The cytoskeleton and disease. J Pathol. 2004;204(4):351-4
  3. Vindin H, Gunning P. Cytoskeletal tropomyosins: choreographers of actin filament functional diversity. J Muscle Res Cell Motil. 2013;34(3-4):261-74. doi: 10.1007/ s10974-013-9355-8
  4. Lodish A, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell J. (2000) The actin cytoskeleton. Section 18:1, Molecular Cell Biology, 4th Edition. W.H. Freeman and Company, New York 6. Huber, F., J. Schnauß, Rönicke S, Rauch P, Müler K, Fütterer C, Käs J. "Emergent complexity of the cytoskeleton: from single filaments to tissue." Advances in Physics 2013; 62(1): 1-112 7. Sept, J. Xu, T.D. Pollard, and J.A. McCammon, Biophys. J. 1999; 77: 2911–2919
  5. Haarer B, Mi-Mi L, Cho J, Cortese M, Viggiano S, Burke D, Amberg D.Actin dosage lethality screening in yeast mediated by selective ploidy ablation reveals links to urmylation/wobble codon recognition and chromosome stability. G3 (Bethesda). 2013;3(3):553-61. doi: 10.1534/g3.113.005579
  6. Higgs HN. Formin proteins: a domain-based approach. Trends Biochem Sci. 2005;30(6):342-53
  7. Mizuno H, Higashida C, Yuan Y, Ishizaki T, Narumiya S, Watanabe N. Rotational movement of the formin mDia1 along the double helical strand of an actin filament. Science. 2011;331(6013):80-3
  8. Goode BL, Eck MJ. Mechanism and function of formins in the control of actin assembly. Annu Rev Biochem. 2007;76:593-627
  9. Eira J, Silva CS1, Sousa MM2, Liz MA3. The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders. Prog Neurobiol. 2016 Jun;141:61-82. doi: 10.1016/j.pneurobio.2016.04.00 13. Penzes P, Vanleeuwen JE. Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease. Brain Res Rev. 2011;67(1-2):184-92. doi: 10.1016/j.brainresrev.2011.01.003
  10. Munsie LN, Truant R. The role of the cofilin-actin rod stress response in neurodegenerative diseases uncovers potential new drug targets. Bioarchitecture. 2012;2(6):204-8. doi: 10.4161/bioa.22549
  11. Nowak K, McCullagh K, Poon E, Davies KE. Muscular dystrophies related to the cytoskeleton/nuclear envelope. Novartis Found Symp. 2005;264:98-111; discussion 112-7, 227-30
  12. Clarkson E, Costa CF, Machesky LM. Congenital myopathie