Journals / Acta Medica Alanya / 2021 / Cilt: 5 - Sayı: 1

Seasonal Variation of Immune Hemolytic Anemia

İmmün Hemolitik Aneminin Mevsimsel Değişkenliği

Pages
36–41
Publication Date
2022-09-04
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

More prospective studies are needed to support these findings in this study.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Immune hemolytic anemia is an autoimmune disease that is related to autoantibodies against erythrocytes.
📊
Key Findings & Data:Methods: It was investigated whether the patients with immune hemolytic anemia who were diagnosed and followed in the hematology outpatient and inpatient clinic of Suleyman Demirel University from 2002 to 2018 had a significant seasonality.
💡
Conclusion & Impact:More prospective studies are needed to support these findings in this study.
🔬Design:Research Article
📍Scope:2002 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: Immune hemolytic anemia is an autoimmune disease that is related to autoantibodies against erythrocytes. Such antibodies appear for a variety of reasons such as hematologic and oncologic malignancies, infections, and connective tissue diseases but in many cases, a true etiologic agent has not been discovered. Many hematologic, as well as rheumatologic disorders, have seasonal variations but there have not been many studies evaluating the possibility of seasonal variation of immune hemolytic anemia. Methods: It was investigated whether the patients with immune hemolytic anemia who were diagnosed and followed in the hematology outpatient and inpatient clinic of Suleyman Demirel University from 2002 to 2018 had a significant seasonality. We also evaluated whether there was any seasonality relationship between gender and beginning of the hemolytic attacks. Results: There was no significant difference when seasons were grouped as spring, summer, autumn and winter, according to gender (p = 0,122). The evaluation of seasons in two groups as autumn-winter and spring-Summer revealed that male patients tended to suffer immune hemolytic anemia in autumn-winter, whereas females, significantly, tend to contract the disease in spring-Summer (p=0,046). Conclusion: Immune hemolytic anemia had significant seasonality pattern depending on gender. More prospective studies are needed to support these findings in this study.

Özet

Amaç: İmmün hemolitik anemi, eritrositlerle ilişkili otoantikorlara bağlı otoimmün bir hastalıktır. Bu tür antikorlar, hematolojik ve onkolojik maligniteler, enfeksiyonlar ve bağ dokusu hastalıkları gibi çeşitli nedenlerle ortaya çıkar ancak, bazı durumlarda, etyolojik faktör tespit edilememektedir. Hematolojik ve romatolojik bozuklukların birçoğunun mevsimsel varyasyonları vardır, ancak immün hemolitik aneminin mevsimsel değişim olasılığını değerlendiren çok fazla çalışma yoktur. Metot: 2002-2018 yılları arasında Süleyman Demirel Üniversitesi hematoloji polikliniğinde ve yatarak tedavi kliniğinde tanı ve takibi yapılan immün hemolitik anemili hastaların anlamlı mevsimselliğe sahip olup olmadığı araştırıldı. Ayrıca, immün hemolitik anemi atağının başlangıcı ile cinsiyetler arasında mevsimsellik ilişkisi olup olmadığı araştırıldı. Bulgular: Cinsiyete göre mevsimler ilkbahar, yaz, sonbahar ve kış olarak gruplandırıldığında anlamlı fark yoktu (p = 0,122). Mevsimleri sonbahar-kış ve ilkbahar-yaz olarak iki grupta değerlendirdiğimizde, erkek hastaların sonbahar-kış aylarında immün hemolitik anemiye eğilimli olduklarını, kadınların ise ilkbahar-yaz aylarında önemli ölçüde hastalığa yakalanma eğiliminde olduklarını bulduk. Sonuç: İmmün hemolitik aneminin, cinsiyete bağlı olarak, istatistiksel olarak anlamlı mevsimsellik paterni olduğunu gösterdik. Bu çalışmadaki bulguları desteklemek için daha fazla prospektif çalışmaya ihtiyaç vardır.

🔖

Cite This Article

Ozbalci, D., Alanoglu, E. G., Sak, R. (2022). Seasonal Variation of Immune Hemolytic Anemia. Acta Medica Alanya, Cilt: 5 - Sayı: 1, 36–41. https://ajindex.com/articles/425754

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Liebmann HA, Wietz IC. Autoimmune hemolytic anemia. Med Clin N Am 2017;101(2):351–9 doi: 10.1016/j.mcna.2016.09.007
  2. Quist E, Koepsell S. Autoimmune Hemolytic Anemia and Red Blood Cell Autoantibodies. Arch Pathol Lab Med. 2015;139(11):1455-8. doi: 10.5858/arpa.2014-0337-RS
  3. Naik R. Warm autoimmune hemolytic anemia. Hematol Oncol Clin North Am. 2015;29(3):445-53. doi: 10.1016/j.hoc.2015.01.001
  4. Shulman IA, Branch DR, Nelson JM, Thompson JC, Saxena S, Petz LD. Autoimmune hemolytic anemia with both cold and warm autoantibodies. JAMA. 1985;253(12):1746-8. PMID: 3974053
  5. Shanbhag S, Spivak J. Paroxysmal cold hemoglobinuria. Hematol Oncol Clin North Am. 2015;29(3):473-8. doi: 10.1016/j.hoc.2015.01.004
  6. Kalfa TA. Warm antibody autoimmune hemolytic anemia. Hematology Am Soc Hematol Educ Program. 2016;2016(1):690-7. doi: 10.1182/asheducation-2016.1.690
  7. Karimi M, Yarmohammadi H. Seasonal variations in the onset of childhood leukemia/lymphoma: April 1996 to March 2000, Shiraz, Iran. Hematol Oncol. 2003;21(2):51-5. doi: 10.1002/hon.702
  8. Calip GS, McDougall JA, Wheldon MC, Li CI, De Roos AJ. Evaluation of seasonality in the diagnosis of acute myeloid leukaemia among adults in the United States, 1992-2008. Br J Haematol. 2013;160(3):343-50. doi: 10.1111/bjh.12137
  9. Borchmann S, Müller H, Engert A. Hodgkin Lymphoma has a seasonal pattern of incidence and mortality that depends on latitude. Sci Rep. 2017;7(1):14903. doi: 10.1038/s41598-017-14805-y
  10. Raval JS, Harm SK, Rollins-Raval MA, Kiss JE. Seasonal distribution of severe ADAMTS13 deficient idiopathic thrombotic thrombocytopenic purpura. J Clin Apher. 2014;29(2):113-9. doi: 10.1002/jca.21300
  11. Park YA, Poisson JL, McBee MT, Afenyi-Annan A. Seasonal association of thrombotic thrombocytopenic purpura. Transfusion. 2012;52(7):1530-4. doi: 10.1111/j.1537-2995.2011.03481.x
  12. Tombak A, Boztepe B, Tiftik N, Cömert M, Salim O, Aydın K, et al. Seasonal Association of Immune Thrombocytopenia in Adults. Balkan Med J. 2015;32(4):347-51. doi: 10.5152/balkanmedj.2015.151223
  13. Moulis G, Guénin S, Limal N, Michel M, Bierling P, Godeau B, et al. Seasonal variations of incident primary immune thrombocytopenia in adults: An ecological study. Eur J Intern Med. 2017;37: e26-e28. doi: 10.1016/j.ejim.2016.09.025
  14. Giri S, Pathak R, Aryal MR, Karmacharya P, Bhatt VR, Martin MG. Seasonal variation of immune thrombocytopenic purpura related hospitalizations among adults in the USA: analysis of the nati