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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2004 / Cilt: 12 - Sayı: 1

Use of sodium nitroprusside and papaverine solution in preparation of saphenous vein

Safen ven hazırlanmasında sodyum nitroprussid ve papaverin kullanımı

Ahmet ORUÇ
Nesimi EREN
Kemalettin ERDEM
Fetin YILDIZ
Ömer ÇAKIR
Pages
35–39
Publication Date
2022-09-02
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Score in sodium nitroprusside group was found to be significantly better than the others.Conclusions: Our results show that supplementation of sodium nitroprusside to the preservation solution preserves the endothelium.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: The aim of this study was to compare the endothelial damage in saphenous veins created with sodium nitroprusside and papaverine.
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Key Findings & Data:Saphenous vein grafts were distended in the heparinized lactated ringer's solution at pressure not exceeding 20 mmHg in Group 1 (Control group), and distended 80 mmHg in Group 2 (Lactated Ringer's group).
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Conclusion & Impact:Score in sodium nitroprusside group was found to be significantly better than the others.Conclusions: Our results show that supplementation of sodium nitroprusside to the preservation solution preserves the endothelium.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: The aim of this study was to compare the endothelial damage in saphenous veins created with sodium nitroprusside and papaverine. Methods: Human saphenous vein graft was obtained from ten patients and then divided into four equal parts. Saphenous vein grafts were distended in the heparinized lactated ringer's solution at pressure not exceeding 20 mmHg in Group 1 (Control group), and distended 80 mmHg in Group 2 (Lactated Ringer's group). Saphenous vein grafts were distended in the heparinized lactated Ringer's solution containing papaverine at pressure not exceeding 80 mmHg in Group 3 (Papaverine group), and distended at same pressure in the heparinized lactated Ringer's solution containing sodium nitroprusside in Group 4 (Sodium Nitroprusside group). Vein segments were storaged in these solutions at room temperature for one hour. All saphenous vein segments were examined under light microscope for loss of the endothelium and damage to the media and scored from 0 to 3. Results: The mean scores were 0.7 ± 0.82 in Group 1, 1.3 + 0.67 in Group 2, 2.0 + 0.66 in Group 3 and, 1.1 ± 0.87 in Group 4. Score in sodium nitroprusside group was found to be significantly better than the others.Conclusions: Our results show that supplementation of sodium nitroprusside to the preservation solution preserves the endothelium.

Özet

Amaç: Bu çalışmanın amacı safen yenlerde sodyum nitroprussid ve papaverin kullanımı ile olan endotel hasarını karşılaştırmaktır. Materyal ve Metod: On hastadan alınan safen venler 4 eşit parçaya bölündü. Grup l 'de (Kontrol grubu) safen venler heparinize laktatlı ringer solüsyonunda 20 mmHg basınçla, Grup 2'de (Laktatlı Ringer grubu) 80 mmHg basınçla şişirildi. Grup 3'de (Sodyum nitroprussid grubu) safen venler sodyum nitroprussidli heparinize laktatlı ringer solüsyonunda, Grup 4'de (Papaverin grubu) ise papaverinli heparinize laktatlı ringer solüsyonunda 80 mmHg basınçlarla şişirildi. Parçalar ilgili solüsyonlarda oda ısısında bir saat bekletildi. Tüm safen venler ışık mikroskobu ile endotel ve media hasarı yönünden incelendi ve O ile 3 arasında skorlandı. Bulgular: Ortalama skorlar Grup l'de 0.7 ± 0.82, Grup 2'de 1.3 + 0.67, Grup 3'de 2.0 + 0.66 ve Grup 4'de 1.1 + 0.87 olarak bulundu. Sodyum nitroprussid grubunda skorun diğerlerinden daha iyi olduğu tespit edildi. Sonuç: Çalışmamızın sonucu olarak, safen ven saklama solüsyonuna sodyum nitroprussid eklenmesinin endoteli daha iyi koruduğu görülmektedir.

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Cite This Article

ORUÇ, A., EREN, N., ERDEM, K., YILDIZ, F., ÇAKIR, Ö. (2022). Use of sodium nitroprusside and papaverine solution in preparation of saphenous vein. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 12 - Sayı: 1, 35–39. https://ajindex.com/articles/425369

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