Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2007 / Cilt: 15 - Sayı: 2

Hafif-orta derece hipertansiyon ve tip 1 diabetes mellitus olan hastalarda ambulatuvar kan basıncı değerleri ile sol ventrikül parametreleri ve geometrisi arasındaki ilişkiler

Correlations between ambulatory blood pressure variables and left ventricular parameters and geometry in patients with mild to moderate hypertension and type 1 diabetes mellitus

Pages
143–149
Publication Date
2022-09-02
DOI
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The incidence of eccentric hypertrophy was significantly higher in nondippers (p=0.017).Conclusion: Nondipping status revealed by ABPM may have a significant impact on LV geometry and determine the type of LV hypertrophy in hypertensive patients with type 1 DM.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: We investigated the efficiency of ambulatory blood pressure monitoring (ABPM) in detecting early alterations in blood pressure (BP) in young patients with mild to moderate hypertension and type 1 diabetes mellitus (DM), and sought correlations between ABPM values and the type of left ventricular (LV) hypertrophy.
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Key Findings & Data:Methods: The study included 23 young adults (19 males, 4 females; mean age 26±5 years) with mild to moderate hypertension and type 1 DM.
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Conclusion & Impact:The incidence of eccentric hypertrophy was significantly higher in nondippers (p=0.017).Conclusion: Nondipping status revealed by ABPM may have a significant impact on LV geometry and determine the type of LV hypertrophy in hypertensive patients with type 1 DM.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: We investigated the efficiency of ambulatory blood pressure monitoring (ABPM) in detecting early alterations in blood pressure (BP) in young patients with mild to moderate hypertension and type 1 diabetes mellitus (DM), and sought correlations between ABPM values and the type of left ventricular (LV) hypertrophy. Methods: The study included 23 young adults (19 males, 4 females; mean age 26±5 years) with mild to moderate hypertension and type 1 DM. The patients were evaluated by casual BP measurements and 24-hour ABPM monitoring and were classified as dippers and nondippers according to the nocturnal decrease in BP compared to daytime values (>10% and <10%, respectively). All patients underwent complete two-dimensional transthoracic echocardiography and Doppler evaluations. The results of ABPM were evaluated in relation to left ventricular parameters and geometry. Measurements of BP were compared with a control group consisting of 25 age-matched healthy individuals (21 males, 4 females; mean age 28±4 years).Results: Eleven patients were classified as dippers and 12 patients as nondippers. There were no significant differences between dipper and nondipper patients with respect to age, gender, body mass index, clinical features, and casual and ABPM recordings. All echocardiographic M-mode variables were similar in both patient groups. Concentric hypertrophy was the most frequent LV geometric pattern in the dipper group (45.5%), followed by normal geometry (27.3%), concentric geometry (18.2%), and eccentric hypertrophy (9.1%). In the nondipper group, the most common pattern was eccentric hypertrophy (41.7%), followed by concentric hypertrophy (25%), concentric remodeling (25%), and normal geometry (8.3%). The incidence of eccentric hypertrophy was significantly higher in nondippers (p=0.017).Conclusion: Nondipping status revealed by ABPM may have a significant impact on LV geometry and determine the type of LV hypertrophy in hypertensive patients with type 1 DM.

Özet

Amaç: Hafif-orta derece hipertansiyonlu, tip 1 diabetes mellitusu (DM) olan genç hastalarda, erken kan basıncı değişikliklerinin değerlendirilmesinde ambulatuvar kan basıncı ölçümünün (AKBÖ) etkinliği değerlendirildi ve AKBÖ verileri ile sol ventrikül hipertrofi tipleri arasındaki ilişkiler araştırıldı. Çalışma planı: Çalışmada hafif-orta derece hipertansiyonu ve tip 1 DM olan 23 genç erişkin hasta (19 erkek, 4 kadın; ort. yaş 26±5) incelendi. Kan basıncı klinik olarak ve 24 saatlik AKBÖ ile ölçüldü. Hastalar, gece kan basıncı gündüz basıncından %10’dan fazla düşmüş ise dipper, %10’dan az düşmüş ise non-dipper olarak sınıflandırıldı. Tüm hastalar ikiboyutlu transtorasik ekokardiyografi ve Doppler ile değerlendirildi ve AKBÖ bulgularının sol ventrikül parametreleri ve geometrisi ile ilişkisi araştırıldı. Ayrıca, hasta grubunun kan basıncı ölçümleri, yaş uyumlu 25 sağlıklı gönüllüden oluşan kontrol grubuyla (21 erkek, 4 kadın; ort. yaş 28±4) karşılaştırıldı.Bulgular: On bir hastada dipper, 12 hastada non-dipper durum saptandı. İki hasta grubu arasında yaş, cinsiyet, beden kütle indeksi, klinik özellikler, klinik olarak ve AKBÖ ile ölçülmüş kan basınçları açısından anlamlı farklılık bulunmadı. M-mod ekokardiyografik değişkenler dipper ve non-dipper olgularında benzerdi. Dipper olgularında en sık rastlanan LV geometrisi konsantrik hipertrofi (%45.5) idi; bunu normal geometri (%27.3), konsantrik geometri (%18.2) ve eksantrik hipertrofi (%9.1) izlemekteydi. Non-dipper olgularında ise en yaygın tür eksantrik hipertrofi (%41.7) iken, konsantrik hipertrofi, konsantrik remodeling ve normal geometriye sırasıyla %25, %25 ve %8.3 oranlarında rastlandı. Eksantrik hipertrofi sıklığı non-dipper olgularında anlamlı derecede fazla bulundu (p=0.017).Sonuç: Tip 1 DM’li hipertansif hastalarda AKBÖ ile ortaya konan non-dipper durumu sol ventrikül geometrisini önemli derecede etkileyerek sol ventrikül hipertrofisi tipini belirleyebilir.

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Cite This Article

DEMİRALP, E., KILIÇARSLAN, F., YAVUZ, İ., KIRILMAZ, A., KÜÇÜKARSLAN, N., ULUSOY, R. E. (2022). Hafif-orta derece hipertansiyon ve tip 1 diabetes mellitus olan hastalarda ambulatuvar kan basıncı değerleri ile sol ventrikül parametreleri ve geometrisi arasındaki ilişkiler. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 15 - Sayı: 2, 143–149. https://ajindex.com/articles/425123

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