AI Summary & Key Takeaways
AI InsightMultiple linear regression analyses show that the Gensini score index was independently associated with plasma TAC levels (r=-0.898, p<0.001) and age (r=0.258, p=0.023).Conclusion: The plasma TAC value, rather than tissue oxidative stress and antioxidant status, is related to atherosclerosis.
📌 3 Key Takeaways
Abstract
Background: We compared the plasma and tissue total antioxidant capacity (TAC) and total oxidant status (TOS) in patients undergoing coronary artery bypass surgery.Methods: The TAC and TOS levels were assessed in the plasma of 30 coronary artery endarterectomy patients and compared to 30 control samples. Atherosclerotic plaque TAC and TOS levels were also evaluated in the patients’ group. The severity of coronary artery disease was calculated with the Gensini score index.Results: The plasma TAC and TOS values were significantly lower in patients than in controls (p=0.008 and p=0.004 respectively). The TAC level was significantly lower in tissue than in plasma (0.11±0.03 mmol Trolox Equiv./L versus 0.65±0.25 mmol Trolox Equiv./L, p<0.001). The level of TOS was significantly higher in plasma than in tissue (0.80±0.46 μmol H2O2 equiv./L versus 10.9±3.7 μmol H2O2 equiv./L, p<0.001). Multiple linear regression analyses show that the Gensini score index was independently associated with plasma TAC levels (r=-0.898, p<0.001) and age (r=0.258, p=0.023).Conclusion: The plasma TAC value, rather than tissue oxidative stress and antioxidant status, is related to atherosclerosis.
Özet
Amaç: Bu çalışmada koroner arter bypass cerrahisi uygulanan hastalarda doku ve plazma total antioksidan kapasite (TAK) ve total oksidan seviye (TOS) değerleri karşılaştırıldı.Çalışma planı: Koroner endearterektomi uygulanan 30 hasta ve 30 sağlıklı kontrolde plazma TAK ve TOS seviyeleri değerlendirildi. Ayrıca hasta grubunda aterosklerotik plak TAK ve TOS seviyelerine bakıldı. Koroner arter hastalığı şiddeti Gensini skor indeksi ile hesaplandı.Bulgular: Plazma TAK ve TOS değerleri hastalarda kontrollere göre daha düşüktü (sırası ile p=0.008 ve p=0.004). Doku TAK seviyesi plazmaya göre anlamlı derecede düşüktü (0.11±0.03 mmol Trolox Equiv./L’ye karşın 0.65±0.25 mmol Trolox Equiv./L, p<0.001). Total oksidan seviye ise plazmada dokuya göre belirgin derecede yüksekti (0.80±0.46 μmol H2O2 equiv./L’ye karşın 10.9±3.7 μmol H2O2 equiv./L, p<0.001). Çoklu regresyon analizinde Gensini skor indeksi sadece plazma TAK seviyeleri (r=-0.898, p<0.001) ve yaş ile (r=0.258, p=0.023) bağımsız ilişki göstermekteydi.Sonuç: Doku oksidatif stres ve antioksidan kapasiteden ziyade plazma TAK seviyeleri ateroskleroz ile ilişki göstermektedir.