Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2011 / Cilt: 19 - Sayı: 3

Ortalama trombosit hacmi mekanik kapak trombozuna işaret eden bir belirteç olabilir mi?

Could mean platelet volume be a predictive marker for mechanical valve thrombosis?

Pages
301–304
Publication Date
2022-09-02
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, mean platelet volume might be used as a follow-up marker of thrombosis in patients with mechanical valve thrombosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: In this study, we investigated the clinical importance and possibility of mean platelet volume to be a predictive marker for acute mechanical valve thrombosis.
📊
Key Findings & Data:Methods: Mean platelet volume was measured in 28 consecutive patients (mean age 47.3±12.8 years) with mechanical valve thrombosis and 91 control subjects (mean age 46.1±5.8 years).
💡
Conclusion & Impact:Therefore, mean platelet volume might be used as a follow-up marker of thrombosis in patients with mechanical valve thrombosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: In this study, we investigated the clinical importance and possibility of mean platelet volume to be a predictive marker for acute mechanical valve thrombosis. Methods: Mean platelet volume was measured in 28 consecutive patients (mean age 47.3±12.8 years) with mechanical valve thrombosis and 91 control subjects (mean age 46.1±5.8 years). In the study group, blood samples were collected at the first admission (group 1, first measurement) and in the postoperative routine control after discharge (group 1, second measurement). The first control group (group 2) was defined by having a mechanical valve with no history of thrombosis of the mechanical valve. The second control group (group 3) was selected in a consecutive manner from the catheterized cardiac patients who proved to have normal coronary angiograms. Diagnosis of mechanical valve obstruction was based on clinical examination, echocardiography, and cinefluoroscopy. Results: Mean platelet volume was significantly higher in group 1 (first measurement) patients than in group 1 (second measurement), group 2 and group 3 patients (p 0.05). Conclusion: It was shown for the first time that patients with mechanical valve thrombosis have higher mean platelet volumes than control subjects. Therefore, mean platelet volume might be used as a follow-up marker of thrombosis in patients with mechanical valve thrombosis.

Özet

Amaç: Bu çalışmada ortalama trombosit hacminin mekanik kapak trombozundaki klinik önemi ve akut mekanik kapak trombozuna işaret eden bir belirteç olma olasılığı araştırıldı. Çalışma planı: Ortalama trombosit hacmi mekanik kapak trombozu olan ardışık 28 hastada (ort. yaş 47.3±12.8 yıl) ve 91 kontrol olgusunda (ort. yaş 46.1±5.8 yıl) ölçüldü. Çalışma grubunda kan örnekleri ilk başvuruda (grup 1, ilk ölçüm) ve taburcu olduktan sonraki ameliyat sonrası rutin kontrolde (grup 1, ikinci ölçüm) toplandı. İlk kontrol grubu (grup 2) mekanik kapağı olan, mekanik kapak trombozu öyküsü olmayanlar olarak tanımlandı. İkinci kontrol grubu (grup 3) kateterizasyon yapılan ve normal koroner anjiyogramları olan kardiyak hastalar arasından ardışık bir şekilde seçildi. Mekanik kapak obstrüksiyonu tanısı klinik inceleme, ekokardiyografi ve sinefloroskopi temel alınarak konuldu. Bulgular: Ortalama trombosit hacmi grup 1’deki (ilk ölçüm) hastalarda diğer grup 1 (ikinci ölçüm), grup 2 ve grup 3’deki hastalardan anlamlı olarak yüksek idi (p 0.05). Sonuç: Mekanik kapak trombozu olan hastalarda ortalama trombosit hacminin kontrol grubuna göre daha yüksek olduğu ilk defa gösterildi. Bu nedenle ortalama trombosit hacmi, mekanik kapak trombozu olan hastalarda trombozun takip belirteci olarak kullanılabilir.

🔖

Cite This Article

YALÇINKAYA, A., PAÇ, M., TAŞOĞLU, İ., LAFÇI, G., SARITAŞ, A., ULAŞ, M. M., ÇİÇEK, Ö. F., ULUS, A. T. (2022). Ortalama trombosit hacmi mekanik kapak trombozuna işaret eden bir belirteç olabilir mi?. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 19 - Sayı: 3, 301–304. https://ajindex.com/articles/424878

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002;117:399-404
  2. Dalby Kristensen S, Milner PC, Martin JF. Bleeding time and platelet volume in acute myocardial infarction-a 2 year follow-up study. Thromb Haemost 1988;59:353-6
  3. Jakubowski JA, Adler B, Thompson CB, Valeri CR, Deykin D. Influence of platelet volume on the ability of prostacyclin to inhibit platelet aggregation and the release reaction. J Lab Clin Med 1985;105:271-6
  4. O’Malley T, Langhorne P, Elton RA, Stewart C. Platelet size in stroke patients. Stroke 1995;26:995-9
  5. Butterworth RJ, Bath PM. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets 1998;9:359-64
  6. Cameron HA, Phillips R, Ibbotson RM, Carson PH. Platelet size in myocardial infarction. Br Med J (Clin Res Ed) 1983;287:449-51
  7. Sen N, Tavil Y, Yazici HU, Hizal F, Açikgöz SK, Abaci A, et al. Mean platelet volume in patients with coronary artery ectasia. Med Sci Monit 2007;13:CR356-9
  8. Martin JF, Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet 1991; 338:1409-11
  9. Pizzulli L, Yang A, Martin JF, Lüderitz B. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J 1998;19:80-4
  10. Henning BF, Zidek W, Linder B, Tepel M. Mean platelet volume and coronary heart disease in hemodialysis patients. Kidney Blood Press Res 2002;25:103-8
  11. Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol 1992;14:281-7
  12. Trowbridge EA, Martin JF. The platelet volume distribution: a signature of the prethrombotic state in coronary heart disease? Thromb Haemost 1987;58:714-7
  13. Barron HV, Cannon CP, Murphy SA, Braunwald E, Gibson CM. Association between white blood cell count, epicardial blood flow, myocardial perfusion, and clinical outcomes in the setting of acute myocardial infarction: a thrombolysis in myocardial infarction 10 substudy. Circulation 2000;102:2329-34
  14. Marx N, Neumann FJ, Ott I, Gawaz M, Koch W, Pinkau T, Schömig A. Induction of cytokine expression in leukocytes in acute myocardial infarction. J Am Coll Cardiol 1997;30:165-70
  15. Neumann FJ, Ott I, Marx N, Luther T, Kenngott S, Gawaz M, et al. Effe