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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2011 / Cilt: 19 - Sayı: 2

Multi-drug resistance [MDR-1 (ABCB1)] 3435 geni C>T varyantı ve abdominal aort anevrizması arasındaki ilişki: Pilot çalışma10.5606/tgkdc.dergisi.2011.008

Associations between common 3435 C>T variants of the multi-drug resistance [MDR-1 (ABCB1)] gene and abdominal aortic aneurysm: A pilot study

Oğuz KARAHAN
Nurkay KATRANCIOĞLU
Öztürk ÖZDEMİR
Öcal BERKAN
Şinasi MANDUZ
Mehmet Birhan YILMAZ
Pages
177–181
Publication Date
2022-09-21
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The demographic findings were similar in each group.Conclusion: These obtained preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with AAA.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: The aim of the study was to reveal the effect of the C3435T MDR-1 gene polymorphism in AAA, which has been postulated to play a role in the inflammatory process and protection against oxidative stress.
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Key Findings & Data:Methods: In this study, we scanned the MDR gene polymorphisms in peripheral blood samples of the 58 patients (41 males, 17 females; mean age 62.9±6.6 years) whom were operated on after the diagnosis of AAA, and of the 58 healthy individuals (38 males, 20 females; mean age 58.8±11.6 years) have normally measured aorta diameters on abdominal computed tomography scan.Results: We found that MDR-1 C3435T gene CT variant (x2= 5.80; p=0.016) and MDR-1 C3435T gene TT variant (x2=11.47; p=0.001) polymorphisms was statistically significant in AAA cases (p<0.05).
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Conclusion & Impact:The demographic findings were similar in each group.Conclusion: These obtained preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with AAA.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: The aim of the study was to reveal the effect of the C3435T MDR-1 gene polymorphism in AAA, which has been postulated to play a role in the inflammatory process and protection against oxidative stress. Methods: In this study, we scanned the MDR gene polymorphisms in peripheral blood samples of the 58 patients (41 males, 17 females; mean age 62.9±6.6 years) whom were operated on after the diagnosis of AAA, and of the 58 healthy individuals (38 males, 20 females; mean age 58.8±11.6 years) have normally measured aorta diameters on abdominal computed tomography scan.Results: We found that MDR-1 C3435T gene CT variant (x2= 5.80; p=0.016) and MDR-1 C3435T gene TT variant (x2=11.47; p=0.001) polymorphisms was statistically significant in AAA cases (p<0.05). The demographic findings were similar in each group.Conclusion: These obtained preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with AAA. We belive that such molecular studies will blaze a trail for future studies on the understanding of AAA etiology.

Özet

Amaç: Bu çalışmada, inflamatuvar süreç ve oksidatif strese karşı rol oynadığı ileri sürülen C3435T multi drug rezistans-1 (MDR-1) gen polimorfizminin AAA'daki etkisi ortaya konuldu. Çalışma planı: Bu çalışmada servisimizde AAA tanısı konulduktan sonra ameliyat edilen 58 hasta (41 erkek, 17 kadın; ort. yaş 62.9±6.6) ile abdominal bilgisayarlı tomografi taramasında aort çapları normal olarak ölçülen 58 sağlıklı kişinin (38 erkek, 20 kadın; ort. yaş 58.8±11.6 yıl) periferik kan örneklerinde MDR gen mutasyonu tarandı.Bulgular: MDR-1 C3435T geni CT varyant (x2=5,80, p=0.016) ve MDR-1 C3435T geni TT varyant (x2=11.47 p=0.001) polimorfizmleri AAA'lı hastalarda istatistiksel olarak anlamlı bulundu (p<0.05). Demografik bulgular gruplar arasında benzerdi.Sonuç: Elde edilen ilk sonuçlar MDR-1 geni T alleli polimorfizminin AAA ile ilişkili olduğunu düşündürmektedir. Bu ve benzeri moleküler çalışmaların AAA etyolojisinin anlaşılmasında gelecekte yapılacak çalışmalara öncü olacağı kanaatindeyiz.

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Cite This Article

KARAHAN, O., KATRANCIOĞLU, N., ÖZDEMİR, Ö., BERKAN, Ö., MANDUZ, Ş., YILMAZ, M. B. (2022). Multi-drug resistance [MDR-1 (ABCB1)] 3435 geni C>T varyantı ve abdominal aort anevrizması arasındaki ilişki: Pilot çalışma10.5606/tgkdc.dergisi.2011.008. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 19 - Sayı: 2, 177–181. https://ajindex.com/articles/424804

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