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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2013 / Cilt: 21 - Sayı: 4

Mekanik kalp kapağı disfonksiyonunda genetik polimorfizmlerin etkisi

The effect of genetic polymorphisms on the mechanical heart valve dysfunction

Ali İhsan PARLAR
Ufuk TÜTÜN
Seyhan BABAROĞLU
Ahmet Tulga ULUS
Mustafa SEREN
Ferit ÇİÇEKCİOĞLU
Salih Fehmi KATIRCIOĞLU
Müge MISIRLIOĞLU
Pages
905–910
Publication Date
2022-09-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The IL-6 G-174C polymorphism was found tobe significantly associated with mechanical heart valvedysfunction.Conclusion: Interleukin-6, the key inflammatory responsecytokine, may play an effective role in mechanical heartvalve dysfunction possibly through ongoing chronicinflammatory processes.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: This study aims to investigate geneticpolymorphisms in patients with mechanical heart valvedysfunction.Methods: Between January 1994 and December 2004,a total of 83 patients including 18 patients who werereoperated due to mechanical heart valve dysfunction(group 1), 15 patients with normal functions with lowerinternational normalized ratio (INR) levels who underwentmechanical valve replacement (group 2), and 50 healthyindividuals (group 3) were included.
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Key Findings & Data:Factor V Leiden,prothrombin, interleukin (IL-6), and tumor necrosis factoralpha (TNF-a) polymorphisms were investigated forpossible relationships between these factors and mechanicalheart valve dysfunction.Results: A significant difference in IL-6 polymorphismwas found between group 1 and group 3 (p<0.05).Other polymorphisms were not significantly associatedwith mechanical heart valve dysfunction among thegroups.
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Conclusion & Impact:The IL-6 G-174C polymorphism was found tobe significantly associated with mechanical heart valvedysfunction.Conclusion: Interleukin-6, the key inflammatory responsecytokine, may play an effective role in mechanical heartvalve dysfunction possibly through ongoing chronicinflammatory processes.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Domain Parameters

Abstract

Background: This study aims to investigate geneticpolymorphisms in patients with mechanical heart valvedysfunction.Methods: Between January 1994 and December 2004,a total of 83 patients including 18 patients who werereoperated due to mechanical heart valve dysfunction(group 1), 15 patients with normal functions with lowerinternational normalized ratio (INR) levels who underwentmechanical valve replacement (group 2), and 50 healthyindividuals (group 3) were included. Factor V Leiden,prothrombin, interleukin (IL-6), and tumor necrosis factoralpha (TNF-a) polymorphisms were investigated forpossible relationships between these factors and mechanicalheart valve dysfunction.Results: A significant difference in IL-6 polymorphismwas found between group 1 and group 3 (p<0.05).Other polymorphisms were not significantly associatedwith mechanical heart valve dysfunction among thegroups. The IL-6 G-174C polymorphism was found tobe significantly associated with mechanical heart valvedysfunction.Conclusion: Interleukin-6, the key inflammatory responsecytokine, may play an effective role in mechanical heartvalve dysfunction possibly through ongoing chronicinflammatory processes.

Özet

Amaç: Bu çalışmada, mekanik kalp kapağı disfonksiyonu olan hastalardaki genetik polimorfizmler araştırıldı. Ça­lış­ma pla­nı: Ocak 1994 - Aralık 2004 tarihleri arasında mekanik kalp kapağı disfonksiyonu nedeni ile yenidenameliyat edilen hastaların oluşturduğu 18 hasta (grup 1), normal fonksiyonel olan ve mekanik kalp kapağı replasmanı yapılmış, uluslararası normalleştirilmiş oran (INR) düzeyleri düşük olan 15 hasta (grup 2) ve 50 sağlıklı kişi(grup 3) olmak üzere, toplam 83 hasta çalışmaya dahiledildi. Faktör V Leiden, protrombin, interlökin (IL-6) vetümör nekroz faktör alfa (TNF-a) polimorfizmleri tespit edilerek, mekanik kalp kapağı disfonksiyonu ile olan muhtemel ilişkileri araştırıldı.Bul­gu­lar: İnterlökin-6 polimorfizmi sonuçları, grup 1 vegrup 3 karşılaştırıldığında anlamlı olarak farklı bulundu (p<0.05). Diğer polimorfizmler ve mekanik kalp kapağıdisfonksiyonu açısından gruplar arasında anlamlı birfarklılık görülmedi. İnterlökin-6 G-174C polimorfizmimekanik kalp kapağı disfonksiyonu ile anlamlı olarak ilişkili bulundu. So­nuç: Ana enflamatuvar yanıt sitokini IL-6, muhtemelen devam eden kronik enflamatuvar süreçler ilemekanik kalp kapak disfonksiyonunda etkin bir roloynayabilir.

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Cite This Article

PARLAR, A. İ., TÜTÜN, U., BABAROĞLU, S., ULUS, A. T., SEREN, M., ÇİÇEKCİOĞLU, F., KATIRCIOĞLU, S. F., MISIRLIOĞLU, M. (2022). Mekanik kalp kapağı disfonksiyonunda genetik polimorfizmlerin etkisi. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 21 - Sayı: 4, 905–910. https://ajindex.com/articles/424622

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References (12)

  1. Silber H, Khan SS, Matloff JM, Chaux A, DeRobertis M, Gray R. The St. Jude valve. Thrombolysis as the first line of therapy for cardiac valve thrombosis. Circulation 1993;87:30-7
  2. Lengyel M, Fuster V, Keltai M, Roudaut R, Schulte HD, Seward JB, et al. Guidelines for management of left-sided prosthetic valve thrombosis: a role for thrombolytic therapy. Consensus Conference on Prosthetic Valve Thrombosis. J Am Coll Cardiol 1997;30:1521-6
  3. Horstkotte D, Burckhardt D. Prosthetic valve thrombosis. J Heart Valve Dis 1995;4:141-53
  4. Kottke-Marchant K. Genetic polymorphisms associated with venous and arterial thrombosis: an overview. Arch Pathol Lab Med 2002;126:295-304
  5. Gaudino M, Andreotti F, Zamparelli R, Di Castelnuovo A, Nasso G, Burzotta F, et al. The -174G/C interleukin-6 polymorphism influences postoperative interleukin-6 levels and postoperative atrial fibrillation. Is atrial fibrillation an inflammatory complication? Circulation 2003;108 Suppl 1:II195-9
  6. Gaudino M, Di Castelnuovo A, Zamparelli R, Andreotti F, Burzotta F, Iacoviello L, et al. Genetic control of postoperative systemic inflammatory reaction and pulmonary and renal complications after coronary artery surgery. J Thorac Cardiovasc Surg 2003;126:1107-12
  7. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996;88:3698-703
  8. Louis E, Franchimont D, Piron A, Gevaert Y, Schaaf- Lafontaine N, Roland S, et al. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 1998;113:401-6
  9. Gandrille S, Alhenc-Gelas M, Aiach M. A rapid screening method for the factor V Arg506-->Gln mutation. Blood Coagul Fibrinolysis 1995;6:245-8
  10. Helmy N, Maly FE, Bestmann L. Detection of the single- base substitution -174 G-->C in the interleukin-6 gene by real-time polymerase chain reaction: comment on the article by Moos et al. Arthritis Rheum 2001;44:2213-4
  11. Bertsch T, Zimmer W, Casarin W, Denz C, Quintel M, Fassbender K. Real-time PCR assay with fluorescent hybridization probes for rapid interleukin-6 promoter (-174G- ->C) genotyping. Clin Chem 2001;47:1873-4
  12. Bollag L, Attenhofer Jost CH, Vogt PR, Linka AZ, Rickli H, Oechslin E, et al. Symptomatic mechanical heart valve thrombosis: high mor