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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2013 / Cilt: 21 - Sayı: 2

Effect of cardiopulmonary bypass on acetyl salicylic acid resistance in patients undergoing isolated elective coronary artery bypass graft surgery

İzole elektif koroner arter baypas greft cerrahisi uygulanan hastalarda kardiyopulmoner baypasın asetil salisilik asit direnci üzerine etkisi

Cemal Levent BİRİNCİOĞLU
Hasmet BARDAKÇI
Emre BOYSAN
Ertekin Utku ÜNAL
Kerem YAY
Pages
261–267
Publication Date
2022-09-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Lack of sufficient standardization of the tests for acetyl salicylic acid resistance and high costs lead to this phenomenon which is underestimated among the medical community.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: This study aims to investigate the effects of cardiopulmonary bypass (CPB) on acetyl salicylic acid resistance after coronary artery bypass graft (CABG) surgery.
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Key Findings & Data:The patients were divided into two groups according to the use of CPB as on-pump group (n=20) and off-pump group (n=20).Results: Fourteen of twenty patients in the on-pump group had acetyl salicylic acid resistance, whereas only five of twenty patients in the off-pump group had acetyl salicylic acid resistance.
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Conclusion & Impact:Lack of sufficient standardization of the tests for acetyl salicylic acid resistance and high costs lead to this phenomenon which is underestimated among the medical community.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: This study aims to investigate the effects of cardiopulmonary bypass (CPB) on acetyl salicylic acid resistance after coronary artery bypass graft (CABG) surgery. Methods: Forty consecutive patients who underwent isolated elective CABG surgery in cardiovascular surgery department were prospectively enrolled in this study. The patients were divided into two groups according to the use of CPB as on-pump group (n=20) and off-pump group (n=20).Results: Fourteen of twenty patients in the on-pump group had acetyl salicylic acid resistance, whereas only five of twenty patients in the off-pump group had acetyl salicylic acid resistance. Statistical analyses revealed that the use of CPB increased the risk of acetyl salicylic acid resistance by 46.8 fold.Conclusion: The risk of acetyl salicylic acid resistance increases in patients who undergo CABG surgery using CPB, compared to those who do not undergo surgery without CPB. Lack of sufficient standardization of the tests for acetyl salicylic acid resistance and high costs lead to this phenomenon which is underestimated among the medical community.

Özet

Amaç: Bu çalışmada koroner arter baypas greft (KABG) cerrahisi sonrasında kardiyopulmoner baypasın (KPB) asetil salisilik asit direnci üzerine etkileri araştırıldı. Çalışma planı: Çalışmaya kalp ve damar cerrahisi kliniği’nde izole elektif KABG uygulanan ardışık 40 hasta prospektif olarak dahil edildi. Hastalar KPB kullanımına göre, atan kalp grubu (n=20) ve KPB kullanılmayanlar grubu (n=20) olmak üzere iki gruba ayrıldı.Bulgular: Kardiyopulmoner baypas kullanılan grupta 20 hastanın 14’ünde asetil salisilik asit direnci var iken, atan kalp grubundaki 20 hastanın sadece beşinde asetil salisilik asit direnci vardı. İstatistiksel analizler, KPB’nin asetil salisilik asit direnci gelişme riskini 46.8 kat artırdığını gösterdi.Sonuç: Kardiyopulmoner baypas kullanılarak KABG cerrahisi yapılan hastalarda, KPB kullanılmayanlara kıyasla, asetil salisilik asit direnci artar. Asetil salisilik asit direncini göstermekte kullanılan testlerin yeterli standardizasyonunun olmaması ve maliyetlerinin yüksek olması, bu fenomenin tıp camiasında geri plana atılmasına neden olmaktadır.

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Cite This Article

BİRİNCİOĞLU, C. L., BARDAKÇI, H., BOYSAN, E., ÜNAL, E. U., YAY, K. (2022). Effect of cardiopulmonary bypass on acetyl salicylic acid resistance in patients undergoing isolated elective coronary artery bypass graft surgery. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 21 - Sayı: 2, 261–267. https://ajindex.com/articles/424513

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