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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2014 / Cilt: 22 - Sayı: 4

Pretreatment with carnosol in lung ischemia reperfusion-induced renal injury

Akciğer iskemi reperfüzyonunun tetiklediği böbrek hasarında karnosol ön koşullaması

Burhan APİLİOĞULLARI
Ali YÜCEAKTAŞ
Banu YOLDAŞ
Recep KEŞLİ
Hıdır ESME
Pages
816–820
Publication Date
2022-09-02
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our study result suggests that lung I/R injury causes increased renal tissue MPO and ICAM-1 levels, which are related to activated neutrophil sequestration and carnosol may play a protective role against this kidney injury

📌 3 Key Takeaways

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Objective & Hypothesis:Background: This experimental study aims to investigate the protective effects of carnosol on kidney injury induced by lung ischemia/reperfusion (I/R).
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Key Findings & Data:Group IR; lung I/R group (60 min ischemia-60 min reperfusion), group CIR; bolus injection of carnosol before lung I/R, and group S; sham group (pulmonary hilum was not clamped).
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Conclusion & Impact:Conclusion: Our study result suggests that lung I/R injury causes increased renal tissue MPO and ICAM-1 levels, which are related to activated neutrophil sequestration and carnosol may play a protective role against this kidney injury
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: This experimental study aims to investigate the protective effects of carnosol on kidney injury induced by lung ischemia/reperfusion (I/R). Methods: Twenty-four New Zealand white rabbits were randomized into three groups. Group IR; lung I/R group (60 min ischemia-60 min reperfusion), group CIR; bolus injection of carnosol before lung I/R, and group S; sham group (pulmonary hilum was not clamped). Renal tissue myeloperoxidase (MPO) and intercellular adhesion molecule-1 (ICAM-1) levels were evaluated. Results: Renal tissue MPO and ICAM-1 levels were significantly higher in the group IR compared to the group CIR and group S (p=0.021 and p=0.0001 respectively). No statistically significant difference in the parameters evaluated was detected between the group CIR and the group S. Conclusion: Our study result suggests that lung I/R injury causes increased renal tissue MPO and ICAM-1 levels, which are related to activated neutrophil sequestration and carnosol may play a protective role against this kidney injury

Özet

Amaç: Bu deneysel çalışmada, akciğer iskemi/reperfüzyonu (İ/R) ile indüklenen böbrek hasarı üzerine karnosolun koruyucu etkisi araştırıldı.Ça­lış­ma­ pla­nı:­ Yirmi dört Yeni Zelanda beyaz tavşanı üç gruba randomize edildi. Grup IR; akciğer İ/R grubu (60 dk. iskemi-60 dakika reperfüzyon), grup CIR; akciğer İ/R'si öncesi karnasol bolus enjeksiyonu ve grup S; plasebo grubu (pulmoner hilus klemplenmedi). Böbrek dokusu miyeloperoksidaz (MPO) ve interselüler adezyon molekülü -1 (ICAM-1) düzeyleri değerlendirildi.Bul gu lar: Böbrek dokusu MPO ve ICAM-1 düzeyleri grup IR'de, grup CIR ve grup S ile karşılaştırıldığında, anlamlı olarak daha yüksek idi (sırasıyla, p=0.021 ve p=0.0001). Grup CIR ve grup S arasında ise ölçülen parametrelerde istatistiksel olarak anlamlı fark tespit edilmedi.So nuç: Çalışma sonuçlarımız akciğer İ/R'sine bağlı böbrek hasarında aktif nötrofil sekestrasyonu ile ilişkili MPO ve ICAM-1 düzeylerinin arttığını ve karnosolun bu hasarda koruyucu etkisi olabileceğini göstermektedir

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Cite This Article

APİLİOĞULLARI, B., YÜCEAKTAŞ, A., YOLDAŞ, B., KEŞLİ, R., ESME, H. (2022). Pretreatment with carnosol in lung ischemia reperfusion-induced renal injury. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 22 - Sayı: 4, 816–820. https://ajindex.com/articles/424449

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References (14)

  1. de Perrot M, Liu M, Waddell TK, Keshavjee S. Ischemiareperfusion-induced lung injury. Am J Respir Crit Care Med 2003;167:490-511
  2. Yücel O, Güler A, Şirin Y, Gamsızkan M, Şahin MA, Eken A, et al. Akciğer Easy Applicable Model of Ischemia and Reperfusion on Lung Transplantation. J Clin Anal Med 2010;1:13-20
  3. Wang M, Ji P, Wang R, Zhao L, Xia Z. TRPV1 agonist capsaicin attenuates lung ischemia-reperfusion injury inrabbits. J Surg Res 2012;173:153-60
  4. Pazoki-Toroudi HR, Ajami M, Habibey R. Pre-medication and renal pre-conditioning: a role for alprazolam, atropine, morphine and promethazine. Fundam Clin Pharmacol 2010;24:189-98
  5. Park KM, Han HJ. Prior ischemic treatment renders kidney resistant to subsequent ischemia. J Vet Sci 2002;3:115-22
  6. Seifi B, Kadkhodaee M, Delavari F, Mikaeili S, Shams S, Ostad SN. Pretreatment with pentoxifylline and N-acetylcysteine in liver ischemia reperfusion-induced renal injury. Ren Fail 2012;34:610-5
  7. Yuksel S, Sezer MT, Sahin O, Sutcu R, Koçogullari C, Yilmaz HR, et al. The role of carnitine in preventing renal damage developed as a result of infrarenal aortic ischemiareperfusion. Ren Fail 2011;33:440-9
  8. Oksuz H, Bulbuloglu E, Senoglu N, Ciralik H, Yuzbasioglu MF, Kilinc M, et al. Re-protective effects of pre- and post-laparoscopy conditioning, zinc, pentoxifylline, and N-acetylcysteine in an animal model of laparoscopyinduced ischemia/reperfusion injury of the kidney. Ren Fail 2009;31:297-302
  9. Stokes KY, Abdih HK, Kelly CJ, Redmond HP, BouchierHayes DJ. Thermotolerance attenuates ischemia-reperfusion induced renal injury and increased expression of ICAM-1. Transplantation 1996;62:1143-9
  10. Zhang Q, Huang C, Meng B, Tang T, Shi Q, Yang H. Acute effect of ghrelin on ischemia/reperfusion injury in the rat spinal cord. Int J Mol Sci 2012;13:9864-76
  11. Eren S, Esme H, Balci AE, Cakir O, Buyukbayram H, Eren MN, et al. The effect of aprotinin on ischemia-reperfusion injury in an in situ normothermic ischemic lung model. Eur J Cardiothorac Surg 2003;23:60-5
  12. Li JY, Yin HZ, Gu X, Zhou Y, Zhang WH, Qin YM. Melatonin protects liver from intestine ischemia reperfusion injury in rats. World J Gastroenterol 2008;14:7392-6
  13. Gedik HS, Korkmaz K, Erdem H, Karakilic E, Lafci G, Ankarali H. Protective effect of heparin in the end organ ischemia/reperfusion injury of the lungs and heart. J Cardiothorac Surg 2012;7:123
  14. Esme H, Fidan H, Koken T, Solak O. Effect of lung ischemia- -reperfusion on oxidative