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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2015 / Cilt: 23 - Sayı: 2

On- pump koroner arter baypas greftlemede miyokarde nfarktüsü ile iskemi modifiye albüminin ilişkisi

The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting

İbrahim TURAN
Orhan Veli DOĞAN
Süleyman Caner KARAHAN
Sefer USTA
Selim DEMİR
Süheyla DOĞAN
Mine DEMİRBAŞ
Aşkın KILIÇ
Ümit MENTEŞE
Ahmet Çağrı AYKAN
Pages
245–250
Publication Date
2022-09-02
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Inboth NPMI and PMI groups, the 20 minutes after aortic crossclamping IMA levels were higher compared to the preoperativeIMA levels (p=0.0001, p=0.038, respectively).Conclusion:­ Our study results show that IMA may be anearly marker of myocardial infarction in the ONCABGpatients.

📌 3 Key Takeaways

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Objective & Hypothesis:Background:­ This study aims to evaluate the potential ofischemia-modified albumin (IMA) to predict the myocardialinfarction in on pump coronary artery bypass grafting(ONCABG) patients.Methods: Fifty elective isolated ONCABG patients (41 males,9 females; mean age 66 years; range 56 to 75 years) were includedin the study.
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Key Findings & Data:Patients were divided into perioperative myocardialinfarction (PMI; n=8) and non-infarction (NPMI; n=42) groupsaccording to perioperative cardiac troponin I (cTnI) values andECG findings.
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Conclusion & Impact:Inboth NPMI and PMI groups, the 20 minutes after aortic crossclamping IMA levels were higher compared to the preoperativeIMA levels (p=0.0001, p=0.038, respectively).Conclusion:­ Our study results show that IMA may be anearly marker of myocardial infarction in the ONCABGpatients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background:­ This study aims to evaluate the potential ofischemia-modified albumin (IMA) to predict the myocardialinfarction in on pump coronary artery bypass grafting(ONCABG) patients.Methods: Fifty elective isolated ONCABG patients (41 males,9 females; mean age 66 years; range 56 to 75 years) were includedin the study. Patients were divided into perioperative myocardialinfarction (PMI; n=8) and non-infarction (NPMI; n=42) groupsaccording to perioperative cardiac troponin I (cTnI) values andECG findings. Serum IMA levels were measured preoperatively,20 minutes after aortic cross clamping, 30 minutes, at 3, 6,12 and 24 hours after declamping.Results:­ Compared to the NPMI group, the declamping 30minutes, 3, 6 and 12 hours IMA levels were higher in the PMIgroup (p=0.002, p=0.048, p=0.023, p=0.007, respectively). Inboth NPMI and PMI groups, the 20 minutes after aortic crossclamping IMA levels were higher compared to the preoperativeIMA levels (p=0.0001, p=0.038, respectively).Conclusion:­ Our study results show that IMA may be anearly marker of myocardial infarction in the ONCABGpatients.

Özet

Amaç: Bu çalışmada, iskemi modifiye albümin (İMA)ninon-pump koroner arter baypas greftleme (ONCABG)de ameliyatsırası miyokard enfarktüsünü (PME) erken dönemde öngörebilmepotansiyeli değerlendirildi.Ça­lış­ma­pla­nı:­ Çalışmaya elektif izole ONCABG yapılan50 hasta (41 erkek, 9 kadın; ort. yaş 66 yıl; dağılım 56-75yıl) dahil edildi. Hastalar, ameliyat sırası EKG bulguları vekardiyak troponin I (cTnI) değerlerine göre, PME olanlar (n=8)ve PME olmayanlar (NPME; n=42) olarak gruplandırıldı.Serum İMA düzeyleri ameliyat öncesinde, aortik kros klempkonulduktan 20 dakika sonra, klemp kaldırıldıktan 30 dakika,3, 6, 12 ve 24 saat sonra ölçüldü.Bul gu lar: Klemp kalktıktan 30 dakika, 3, 6 ve 12 saat sonraİMA düzeyleri PME grubunda, NPME grubuna kıyasla, dahayüksekti (sırasıyla, p=0.002, p=0.048, p=0.023, p=0.007).Hem PME hem de NPME grubunda İMA düzeyleri aortik krosklemp konulduktan 20 dakika sonra, ameliyat öncesi İMAdüzeylerine kıyasla yükselmişti (sırasıyla p=0.0001, p=0.038).So­nuç:­ Çalışma bulgularımız, İMAnın ONCABG yapılanhastalarda miyokard infarktüsü için erken bir belirteçolabileceğini göstermektedir.

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Cite This Article

TURAN, İ., DOĞAN, O. V., KARAHAN, S. C., USTA, S., DEMİR, S., DOĞAN, S., DEMİRBAŞ, M., KILIÇ, A., MENTEŞE, Ü., AYKAN, A. Ç. (2022). On- pump koroner arter baypas greftlemede miyokarde nfarktüsü ile iskemi modifiye albüminin ilişkisi. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 23 - Sayı: 2, 245–250. https://ajindex.com/articles/424260

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References (13)

  1. Lafci G, Cagli K, Özcan F. Coronary artery bypass graft surgery: an update. Turk Gogus Kalp Dama 2014;22:211-5
  2. Koksal C, Kudsioglu T, Yapici N, Altuntas Y, Tuncel Z, Aykac Z. A comparison of preconditioning effects of propofol and desflurane on myocardial protection in cardiac surgery. Turk Gogus Kalp Dama 2013;21:371-7
  3. Peivandi AA, Dahm M, Opfermann UT, Peetz D, Doerr F, Loos A, et al. Comparison of cardiac troponin I versus T and creatine kinase MB after coronary artery bypass grafting in patients with and without perioperative myocardial infarction. Herz 2004;29:658-64
  4. Onorati F, De Feo M, Mastroroberto P, Cristodoro L, Pezzo F, Renzulli A, et al. Determinants and prognosis of myocardial damage after coronary artery bypass grafting. Ann Thorac Surg 2005;79:837-45
  5. Noora J, Ricci C, Hastings D, Hill S, Cybulsky I. Determination of troponin I release after CABG surgery. J Card Surg 2005;20:129-35
  6. Tzimas PG, Milionis HJ, Arnaoutoglou HM, Kalantzi KJ, Pappas K, Karfis E, et al. Cardiac troponin I versus creatine kinase-MB in the detection of postoperative cardiac events after coronary artery bypass grafting surgery. J Cardiovasc Surg (Torino) 2008;49:95-101
  7. Petzold T, Feindt P, Sunderdiek U, Boeken U, Fischer Y, Gams E. Heart-type fatty acid binding protein (hFABP) in the diagnosis of myocardial damage in coronary artery bypass grafting. Eur J Cardiothorac Surg 2001;19:859-64
  8. Gaze DC. Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug Metab Pharmacokinet 2009;24:333-41
  9. Shen XL, Lin CJ, Han LL, Lin L, Pan L, Pu XD. Assessment of ischemia-modified albumin levels for emergency room diagnosis of acute coronary syndrome. Int J Cardiol 2011;149:296-8
  10. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes - review and clinical implications. Clin Chem Lab Med 2011;49:177-84
  11. Dong SY, Wang XJ, Xiao F, Wang J, Li YF, Li Y. Detection of perioperative myocardial infarction with ischemia-modified albumin. Asian Cardiovasc Thorac Ann 2012;20:252-6
  12. Pantazopoulos I, Papadimitriou L, Dontas I, Demestiha T, Iakovidou N, Xanthos T. Ischaemia modified albumin in the diagnosis of acute coronary syndromes. Resuscitation 2009;80:306-10
  13. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD; Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction. Third universal definition of myocardial infarction. Circulation 2012;126:2020-35. 14.