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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2015 / Cilt: 23 - Sayı: 1

Nontraumatic muscular hematoma of lower extremity in a patient using warfarin and its relationship with VKORC1, CYP2C9 gene polymorphism

Varfarin kullanan hastada travma olmaksızın gelişen alt ekstremite kas hematomu ve VKORC1, CYP2C9 gen polimorfizmi ile ilişkisi

Nihan EREN KAHYA
Sadık Volkan EMREN
Hale BÜlBÜL
Sadettin USLU
Serhan ÖZYILDIRIM
Pages
150–153
Publication Date
2022-09-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In thisarticle, we report a 79-year-old male patient who developednontraumatic hematoma of left lower extremity despiteusing low-dose warfarin, and whose genetic analysesrevealed CYP2C9*2*3, VKORC1 AA and VKORC1 TTgene polymorphisms.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Warfarin is the most frequently used oral anticoagulant agenttoday.
📊
Key Findings & Data:Warfarin response can be affected by environmentalfactors such as dietary habits and drugs as well as geneticfactors, and this might increase bleeding risk.
💡
Conclusion & Impact:In thisarticle, we report a 79-year-old male patient who developednontraumatic hematoma of left lower extremity despiteusing low-dose warfarin, and whose genetic analysesrevealed CYP2C9*2*3, VKORC1 AA and VKORC1 TTgene polymorphisms.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Warfarin is the most frequently used oral anticoagulant agenttoday. Warfarin response can be affected by environmentalfactors such as dietary habits and drugs as well as geneticfactors, and this might increase bleeding risk. In thisarticle, we report a 79-year-old male patient who developednontraumatic hematoma of left lower extremity despiteusing low-dose warfarin, and whose genetic analysesrevealed CYP2C9*2*3, VKORC1 AA and VKORC1 TTgene polymorphisms.

Özet

Varfarin günümüzde en sık kullanılan oral antikoagülanajandır. Varfarin yanıtı beslenme alışkanlıkları ve ilaçlargibi çevresel faktörlerin yanında genetik faktörlerdende etkilenebilir ve bu da kanama riskini artırabilir. Buyazıda, düşük doz varfarin kullanmasına rağmen solalt ekstremitede travma olmaksızın hematom gelişenve gen analizlerinde CYP2C9*2*3, VKORC1 AA veVKORC1 TT gen polimorfizmi saptanan 79 yaşında birerkek hasta sunuldu.

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Cite This Article

KAHYA, N. E., EMREN, S. V., BÜlBÜL, H., USLU, S., ÖZYILDIRIM, S. (2022). Nontraumatic muscular hematoma of lower extremity in a patient using warfarin and its relationship with VKORC1, CYP2C9 gene polymorphism. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 23 - Sayı: 1, 150–153. https://ajindex.com/articles/424240

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References (11)

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