AI Summary & Key Takeaways
AI InsightThirty five articles were included to the meta-analysis including 131.158 patients who met inclusion criteria.The most possible preoperative risk factors for mediastinitiswere atrial fibrillation, pulmonary disease, diabetesmellitus, renal disease, peripheral vascular disease andsystemic hypertension (p 0.05).Heterogeneity was not observed for four (renal, hepatic,neurological and peripheral vascular diseases) of 12 factors(I 2<25%).Conclusion: The results of our meta-analysis showedthat preoperative co-existing diseases such as pulmonaryhypertension, malignancy, heart failure, hepatic andneurological diseases, and dyslipidemia may not be risk factorsfor the development of mediastinitis following cardiac surgery.
📌 3 Key Takeaways
Abstract
Background: In this review, we aimed to analyze the riskfactors of mediastinitis after open cardiac surgery.Methods: The literature screening was performed at Pubmed,Ovid, and Sciencedirect databases without date limitation.Studies investigating the co-existing diseases were included.The results of trials were evaluated with random or fixedeffect model according to the heterogeneity.Results: A total of 5009 articles were attained after databasesearching. Thirty five articles were included to the meta-analysis including 131.158 patients who met inclusion criteria.The most possible preoperative risk factors for mediastinitiswere atrial fibrillation, pulmonary disease, diabetesmellitus, renal disease, peripheral vascular disease andsystemic hypertension (p 0.05).Heterogeneity was not observed for four (renal, hepatic,neurological and peripheral vascular diseases) of 12 factors(I 2<25%).Conclusion: The results of our meta-analysis showedthat preoperative co-existing diseases such as pulmonaryhypertension, malignancy, heart failure, hepatic andneurological diseases, and dyslipidemia may not be risk factorsfor the development of mediastinitis following cardiac surgery.
Özet
Amaç: Bu derlemede, açık kalp cerrahisinden sonramediastinitin risk etkenleri analiz edildi.Çalışmaplanı: Literatür taraması tarih sınırlaması olmadanPubmed, Ovid ve Sciencedirect veritabanlarında uygulandı.Eş zamanlı hastalıkları araştıran çalışmalar dahil edildi.Çalışma bulguları heterojenite durumuna göre rastgele ya dasabit etki modeli ile değerlendirildi.Bul gu lar: Veritabanı taramasından sonra toplam 5009makale elde edildi. Dahil edilme kriterlerini karşılayan131.158 hastanın yer aldığı 35 makale meta analizedahil edildi. Mediastinit için en olası ameliyat öncesirisk etkenleri atriyal fibrilasyon, pulmoner hastalık,diabetes mellitus, renal hastalık, periferik damar hastalığıve sistemik hipertansiyon idi (p 0.05). Heterojenite 12 etkenin dördünde(renal, hepatik, nörolojik ve periferik damar hastalıkları)gözlenmedi (I 2<%25).Sonuç: Meta analiz sonucu pulmoner hipertansiyon,malignite, kalp yetmezliği, hepatik ve nörolojik hastalıklarve dislipidemi gibi ameliyat öncesi eş zamanlı hastalıklarınkalp cerrahisinden sonra mediastinit gelişimi için risk etkeniolmadığını gösterdi.