Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2015 / Cilt: 23 - Sayı: 2

Ventriküler septal de fekt tamiri sonrası plazma beyin natriüretic peptid değerleri: Olumsuz sonuçların potansiyel öngördürücüsü

Plasma brain natriuretic peptide values after ventricular septal defect repair: a potential predictor of negative outcomes

Pages
209–216
Publication Date
2022-09-02
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The mean preoperativeB-type natriuretic peptide levels were significantly correlatedwith the preoperative mean pulmonary artery pressure(p 0.05), whereasintra-individual B-type natriuretic peptide standard deviationwas correlated with longer times of intensive care unit stay(p<0.003).Conclusion:­ High intra-individual variability in serialmeasurements of B-type natriuretic peptide may be potentially apredictor of adverse outcomes following ventricular septal repair.

📌 3 Key Takeaways

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Objective & Hypothesis:Background:­ This study aims to investigate whether there is alinear relationship between clinical outcomes and plasma brainnatriuretic peptide levels following ventricular septal defect repair.Methods: A prospective cohort study was designed at the pediatriccardiac surgery clinic of our institution.
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Key Findings & Data:This cross-sectionalstudy included 20 patients (13 boys, 7 girls; mean age 9.2±4.3months; range, 4 to 18 months) who underwent ventricular septaldefect repair between February 2012 and September 2012.
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Conclusion & Impact:The mean preoperativeB-type natriuretic peptide levels were significantly correlatedwith the preoperative mean pulmonary artery pressure(p 0.05), whereasintra-individual B-type natriuretic peptide standard deviationwas correlated with longer times of intensive care unit stay(p<0.003).Conclusion:­ High intra-individual variability in serialmeasurements of B-type natriuretic peptide may be potentially apredictor of adverse outcomes following ventricular septal repair.
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Background:­ This study aims to investigate whether there is alinear relationship between clinical outcomes and plasma brainnatriuretic peptide levels following ventricular septal defect repair.Methods: A prospective cohort study was designed at the pediatriccardiac surgery clinic of our institution. This cross-sectionalstudy included 20 patients (13 boys, 7 girls; mean age 9.2±4.3months; range, 4 to 18 months) who underwent ventricular septaldefect repair between February 2012 and September 2012. Bloodsamples were taken at baseline before surgery, followed by sixsampling at different time points during the postoperative course.Results:­ In-hospital mortality was 5%. The mean preoperativeB-type natriuretic peptide levels were significantly correlatedwith the preoperative mean pulmonary artery pressure(p 0.05), whereasintra-individual B-type natriuretic peptide standard deviationwas correlated with longer times of intensive care unit stay(p<0.003).Conclusion:­ High intra-individual variability in serialmeasurements of B-type natriuretic peptide may be potentially apredictor of adverse outcomes following ventricular septal repair.

Özet

Amaç: Bu çalışmada ventriküler septal defekt tamiri sonrasıplazma beyin natriüretik peptid değerleri ile klinik sonuçlararasında doğrusal bir ilişki olup olmadığı araştırıldı.Ça­lış­ma­pla­nı:­ Hastanemiz çocuk kalp cerrahisi kliniğindeprospektif bir kohort çalışması planlandı. Bu kesitselçalışmaya Şubat 2012 - Ekim 2012 tarihleri arasındaventriküler septal defekt tamiri uygulanan 20 hasta (13 erkek,7 kız; ort. yaş 9.2±4.3 ay; dağılım 4-18 ay) alındı. Hastalardancerrahi öncesinde başlangıçta ve cerrahi sonrası dönemde altıfarklı zaman noktasında kan örneklemesi yapıldı.Bul gu lar: Hastane mortalitesi 5% idi. Ortalama B-tipnatriüretik peptid düzeylerinin cerrahi öncesi değeri, cerrahiöncesi pulmoner arter basıncı ile anlamlı bir ilişki gösteriyordu(p 0.05), bireyler içi dağılımın standart sapmasıdaha uzun yoğun bakım kalış süresi ile ilişkili bulundu(p<0.003).So­nuç:­ Ventriküler septal defekt tamiri sonrası, ardışıkB-tip natriüretik peptid ölçümlerinin geniş birey içi dağılımgöstermesi, olumsuz sonuçların muhtemel bir belirteci olabilir.

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Cite This Article

CEYRAN, H., GÜZELMERİÇ, F., BAŞARAN, M., ÇİNE, N., TUNÇER, E., ARSLAN, A., YAVUZER, Y., AKSOY, E. (2022). Ventriküler septal de fekt tamiri sonrası plazma beyin natriüretic peptid değerleri: Olumsuz sonuçların potansiyel öngördürücüsü. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 23 - Sayı: 2, 209–216. https://ajindex.com/articles/424153

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