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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2018 / Cilt: 26 - Sayı: 4

Relationship of genetic factors with development of aortic dissection and aneurysm

Aort anevrizması ve aort diseksiyonu gelişiminin genetik faktörler ile ilişkisi

Ömer Naci EMİROĞULLARI
Aydın TUNÇAY
Elif Funda ŞENER
Rıfat ÖZMEN
Pages
557–564
Publication Date
2022-09-02
DOI
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Comparedto the control group, a higher rate of angiotensin converting enzymeI/D gene polymorphism was detected in the aneurysm group, whilehigher D/D polymorphism rates were found in the dissection group;although not statistically significant.Conclusion: Our study results suggest that the nitric oxidesynthase-3 intron 4b/4b and nitric oxide synthase-3 intron 4b/4agene polymorphisms can be used as a predictor of aortic dissectionand aneurysm development.

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Objective & Hypothesis:Background: This study aims to investigate the relationshipbetween the development of aortic dissections and aneurysmswith the polymorphisms of angiotensin converting enzyme gene,methylenetetrahydrofolate reductase gene, plasminogen activatorinhibitor-1 gene, and nitric oxide synthase gene.Methods: Between April 2009 and July 2014, 38 patients with aorticdissections (28 males, 10 females; mean age 55.1±10.7 years; range,30 to 78 years) and 67 patients with aortic aneurysms (57 males,10 females; mean age 63.0±11.4 years; range, 31 to 82 years) wereincluded in this cross-sectional study.
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Key Findings & Data:The control group consistedof 60 healthy volunteers (41 males, 19 females; mean age 56.3±11.2years; range, 30 to 82 years) without an aortic aneurysm ordissection, as assessed by thoracoabdominal computed tomography.The prespecified four genes were genotyped with competitive allelespecificpolymerase chain reaction.Results: The aortic dissection group had higher nitric oxidesynthase-3 (4b/4b) expression levels, compared to the control group.The aortic aneurysm group had also higher nitric oxide synthase-3(4b/4a) expression levels, compared to the control group.
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Conclusion & Impact:Comparedto the control group, a higher rate of angiotensin converting enzymeI/D gene polymorphism was detected in the aneurysm group, whilehigher D/D polymorphism rates were found in the dissection group;although not statistically significant.Conclusion: Our study results suggest that the nitric oxidesynthase-3 intron 4b/4b and nitric oxide synthase-3 intron 4b/4agene polymorphisms can be used as a predictor of aortic dissectionand aneurysm development.
🔬Design:Research Article
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Background: This study aims to investigate the relationshipbetween the development of aortic dissections and aneurysmswith the polymorphisms of angiotensin converting enzyme gene,methylenetetrahydrofolate reductase gene, plasminogen activatorinhibitor-1 gene, and nitric oxide synthase gene.Methods: Between April 2009 and July 2014, 38 patients with aorticdissections (28 males, 10 females; mean age 55.1±10.7 years; range,30 to 78 years) and 67 patients with aortic aneurysms (57 males,10 females; mean age 63.0±11.4 years; range, 31 to 82 years) wereincluded in this cross-sectional study. The control group consistedof 60 healthy volunteers (41 males, 19 females; mean age 56.3±11.2years; range, 30 to 82 years) without an aortic aneurysm ordissection, as assessed by thoracoabdominal computed tomography.The prespecified four genes were genotyped with competitive allelespecificpolymerase chain reaction.Results: The aortic dissection group had higher nitric oxidesynthase-3 (4b/4b) expression levels, compared to the control group.The aortic aneurysm group had also higher nitric oxide synthase-3(4b/4a) expression levels, compared to the control group. Comparedto the control group, a higher rate of angiotensin converting enzymeI/D gene polymorphism was detected in the aneurysm group, whilehigher D/D polymorphism rates were found in the dissection group;although not statistically significant.Conclusion: Our study results suggest that the nitric oxidesynthase-3 intron 4b/4b and nitric oxide synthase-3 intron 4b/4agene polymorphisms can be used as a predictor of aortic dissectionand aneurysm development.

Özet

Amaç: Bu çalışmada aort diseksiyonu ve anevrizma gelişimi ile anjiyotensin dönüştürücü enzim geni, metilentetrahidrofolat redüktaz geni, plazminojen aktivatör inhibitör-1 geni ve nitrik oksit sentaz geni polimorfizmleri arasındaki ilişki araştırıldı. Çalışma planı: Bu kesitsel çalışmaya Nisan 2009 - Temmuz 2014 tarihleri arasında aort diseksiyonu olan 38 hasta (28 erkek, 10 kadın; ort. yaş 55.1±10.7 yıl; dağılım 30-78 yıl) ve aort anevrizması olan 67 hasta (57 erkek,10 kadın; ort. yaş 63.0±11.4 yıl; dağılım 31-82 yıl) alındı. Kontrol grubu, torakoabdominal bilgisayarlı tomografi ile değerlendirildiği üzere, aort anevrizması veya diseksiyonu olmayan 60 sağlıklı gönüllüden (41 erkek, 19 kadın; ort. yaş 56.3±11.2 yıl; dağılım 30-82 yıl) oluşuyordu. Belirtilen dört genin, kompetitif allel spesifik-polimeraz zincir reaksiyonu ile genotiplemesi yapıldı. Bulgular: Kontrol grubuna kıyasla, aort diseksiyonu grubunda nitrik oksit sentaz-3 (4b/4b) ekspresyon düzeyi daha yüksekti. Kontrol grubuna kıyasla, aort anevrizması grubunda nitrik oksit sentaz-3 (4b/4a) ekspresyon düzeyi daha yüksekti. İstatistiksel olarak anlamlı olmamakla birlikte, kontrol grubuna kıyasla, anevrizma grubunda daha yüksek oranda anjiyotensin dönüştürücü enzim I/D gen polimorfizmi saptanır iken, diseksiyon grubunda daha yüksek D/D polimorfizm oranlarına rastlandı. Sonuç: Çalışma sonuçlarımız, nitrik oksit sentaz-3 intron 4b/4b ve nitrik oksit sentaz-3 intron 4b/4a gen polimorfizmlerinin, aort diseksiyonu ve anevrizma gelişiminin bir öngördürücüsü olarak kullanılabileceğini göstermektedir.

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Cite This Article

EMİROĞULLARI, Ö. N., TUNÇAY, A., ŞENER, E. F., ÖZMEN, R. (2022). Relationship of genetic factors with development of aortic dissection and aneurysm. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 26 - Sayı: 4, 557–564. https://ajindex.com/articles/423836

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