Sublobar resections in early-stage non-small cell lung cancer

Objective & Hypothesis:Background: This study aims to evaluate the outcomes ofsublobar resections in patients with early-stage non-small celllung cancer and to investigate the factors affecting survival.Methods: Medical files of a total of 63 patients (52 males,11 females; mean age 64 years; range, 39 to 81 years) whounderwent sublobar resection for suspected or known early-stagenon-small cell lung cancer between January 2001 and August2013 were retrospectively reviewed.

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Key Findings & Data:Data including demographiccharacteristics of the patients, comorbid conditions, smokingstatus, surgical margin, visceral pleura invasion, distance fromsurgical margin to tumor, tumor size, pathological N status, celltype, tumor localization, and recurrences were recorded.Results: Survival was significantly longer in the patients withnegative surgical margin for tumor (R0) than in those withpositive margin (R1) (94.1 months vs. 32.2 months, p<0.01).Survival was also significantly longer in the patients withoutlymphatic invasion (p<0.01).Conclusion: In early-stage lung tumors, sublobar resection canbe performed, if complete resection is performed.

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Conclusion & Impact:Lymphaticinvasion is a negative prognostic factor for survival followingsublobar resection.

🔬Design:Review & Systematic Survey

📍Scope:2001 Verileri

⚙️Variables:Domain Parameters

Abstract

Background: This study aims to evaluate the outcomes ofsublobar resections in patients with early-stage non-small celllung cancer and to investigate the factors affecting survival.Methods: Medical files of a total of 63 patients (52 males,11 females; mean age 64 years; range, 39 to 81 years) whounderwent sublobar resection for suspected or known early-stagenon-small cell lung cancer between January 2001 and August2013 were retrospectively reviewed. Data including demographiccharacteristics of the patients, comorbid conditions, smokingstatus, surgical margin, visceral pleura invasion, distance fromsurgical margin to tumor, tumor size, pathological N status, celltype, tumor localization, and recurrences were recorded.Results: Survival was significantly longer in the patients withnegative surgical margin for tumor (R0) than in those withpositive margin (R1) (94.1 months vs. 32.2 months, p<0.01).Survival was also significantly longer in the patients withoutlymphatic invasion (p<0.01).Conclusion: In early-stage lung tumors, sublobar resection canbe performed, if complete resection is performed. Lymphaticinvasion is a negative prognostic factor for survival followingsublobar resection.

Özet

Amaç: Bu çalışmada erken evre küçük hücreli dışı akciğer kanserli hastalarda sublobar rezeksiyonların sonuçları değerlendirildi ve sağkalımı etkileyen faktörler araştırıldı. Çalışma planı: Ocak 2011 - Ağustos 2013 tarihleri arasında şüpheli veya bilinen erken evre küçük hücreli dışı akciğer kanseri nedeniyle sublobar rezeksiyon yapılan toplam 63 hastanın (52 erkek, 11 kadın; ort. yaş 64 yıl; dağılım 39-81 yıl) tıbbi dosyası retrospektif olarak değerlendirildi. Hastaların demografik özellikleri, eşlik eden hastalıklar, sigara içiciliği, cerrahi sınır, viseral plevra invazyonu, tümörün cerrahi sınıra uzaklığı, tümör boyutu, patolojik N durumu, hücre tipi, tümör yerleşim yeri ve nüksler kaydedildi. Bulgular: Sağkalım, cerrahi sınırı tümör için negatif olan (R0) hastalarda, pozitif olan (R1) hastalara kıyasla, anlamlı olarak daha uzun (32.2 aya kıyasla 74.1 ay, p<0.01) idi. Lenfatik invazyon olmayan hastalarda da sağkalım anlamlı düzeyde daha uzun idi (p<0.01). Sonuç: Erken evre akciğer tümörlerinde komplet rezeksiyon yapılacak ise, sublobar rezeksiyon yapılabilir. Lenfatik invazyon, sublobar rezeksiyon sonrası sağkalım için negatif prognostik faktördür.

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Cite This Article

ENÖN, S., KUTLAY, H., DUMAN, E., ŞAHİN, M., AKAL, M., YÜKSEL, C., KOCAMAN, G., SAKALLI, M. A., ÖZKAN, M., YENİGÜN, M. B., CANGIR, A. K. (2022). Sublobar resections in early-stage non-small cell lung cancer. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 27 - Sayı: 3, 367–373. https://ajindex.com/articles/423785

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