Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2019 / Cilt: 27 - Sayı: 2

Can functional inoperability in lung cancer patients be changed by pulmonary rehabilitation?

Akciğer kanseri hastalarında fonksiyonel inoperabilite pulmoner rehabilitasyonla değiştirilebilir mi?

Pages
212–218
Publication Date
2022-09-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, it may be useful to refer patients torehabilitation before establishing a decision of inoperability.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: This study aims to investigate the effects of shorttermintense pulmonary rehabilitation on respiratory function inpatients with lung cancer who were defined as inoperable due toinsufficient pulmonary reserve.Methods: A total of 25 patients (24 males, 1 female; mean age62 years; range, 50 to 72 years) who were histologically diagnosed asnon-small cell lung carcinoma, considered functionally inoperabledue to high risk of an estimated postoperative complication, andsuitable for surgical resection according to tumor stage wereincluded in the study.
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Key Findings & Data:Theforced expiratory volume in one second, forced vital capacity,modified Medical Research Council dyspnea scale, six-minutewalking distance, maximal inspiratory and expiratory pressuresfor respiratory muscle strength measurements, and predicted peakmaximal oxygen consumption were examined.Results: After pulmonary rehabilitation, there was statisticallysignificant improvement in the six-minute walking distance(53 m, p<0.001), dyspnea perception (p<0.001), maximalinspiratory pressure (12 cm H2O, p<0.001), forced vital capacity(p<0.001), predicted forced expiratory volume in one second (%)(p=0.001), forced expiratory volume in one second (Δ forcedexpiratory volume in one second= 150 mL, p=0.001; Δ maximumvalue of forced expiratory volume in one second: 650 mL), andpredicted maximal oxygen consumption (p<0.001).
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Conclusion & Impact:Therefore, it may be useful to refer patients torehabilitation before establishing a decision of inoperability.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: This study aims to investigate the effects of shorttermintense pulmonary rehabilitation on respiratory function inpatients with lung cancer who were defined as inoperable due toinsufficient pulmonary reserve.Methods: A total of 25 patients (24 males, 1 female; mean age62 years; range, 50 to 72 years) who were histologically diagnosed asnon-small cell lung carcinoma, considered functionally inoperabledue to high risk of an estimated postoperative complication, andsuitable for surgical resection according to tumor stage wereincluded in the study. Patients received chest physiotherapy,self-walking and inspiratory muscle training for two weeks. Theforced expiratory volume in one second, forced vital capacity,modified Medical Research Council dyspnea scale, six-minutewalking distance, maximal inspiratory and expiratory pressuresfor respiratory muscle strength measurements, and predicted peakmaximal oxygen consumption were examined.Results: After pulmonary rehabilitation, there was statisticallysignificant improvement in the six-minute walking distance(53 m, p<0.001), dyspnea perception (p<0.001), maximalinspiratory pressure (12 cm H2O, p<0.001), forced vital capacity(p<0.001), predicted forced expiratory volume in one second (%)(p=0.001), forced expiratory volume in one second (Δ forcedexpiratory volume in one second= 150 mL, p=0.001; Δ maximumvalue of forced expiratory volume in one second: 650 mL), andpredicted maximal oxygen consumption (p<0.001). At the end ofthe rehabilitation, 60% of the patients (n=15) reevaluated by thesurgeons could be operated.Conclusion: Short-term intensive pulmonary rehabilitationimproves lung functions and exercise capacity while decreasingdyspnea perception. In our study, thanks to the gains derivedfrom the exercise, approximately more than half of the patientscould be operated. Therefore, it may be useful to refer patients torehabilitation before establishing a decision of inoperability.

Özet

Amaç: Bu çalışmada yetersiz pulmoner rezerv nedeniyle inopere olarak tanımlanan akciğer kanserli hastalarda kısa süreli yoğun pulmoner rehabilitasyonun solunum fonksiyonu üzerindeki etkileri araştırıldı. Çalışma planı: Histolojik olarak küçük hücre dışı akciğer kanseri tanısı almış, ameliyat sonrası öngörülen komplikasyon riskinin yüksek olması nedeniyle fonksiyonel olarak inopere olduğu düşünülen ve tümör evresine göre cerrahi rezeksiyon için uygun 25 hasta (24 erkek, 1 kadın; ort. yaş 62 yıl; dağılım, 50-72 yıl) çalışmaya dahil edildi. Hastalara iki hafta boyunca göğüs fizyoterapisi, serbest yürüyüş ve inspiratuar kas eğitimi verildi. Bir saniyedeki zorlu ekspiratuar hacim, zorlu vital kapasite, modifiye Medikal Araştırma Kurulu dispne skalası, altı-dakika yürüme mesafesi, solunum kas kuvveti ölçümleri için maksimal inspiratuar ve ekspiratuar basınçlar ve tahmini zirve maksimal oksijen tüketimi incelendi. Bulgular: Pulmoner rehabilitasyon sonrasında; altı-dakika yürüme mesafesinde (53 m, p<0.001), dispne algısında (p<0.001), maksimal inspiratuar basınçta (12 cm H2O, p<0.001), zorlu vital kapasitede (p<0.001), birinci saniyedeki zorlu ekspiratuar akımın beklenene göre yüzdesinde (p=0.001), bir saniyedeki zorlu ekspiratuar hacimde (Δ bir saniyedeki zorlu ekspiratuar hacim=150 mL, p=0.001; Δ bir saniyedeki zorlu ekspiratuar hacmin maksimum değerinde: 650 mL) ve tahmini maksimal oksijen tüketiminde (p<0.001) istatistiksel olarak anlamlı iyileşme vardı. Rehabilitasyonun sonunda, cerrahlar tarafından tekrar değerlendirilen hastaların %60’ı (n=15) ameliyat edilebildi. Sonuç: Kısa süreli yoğun pulmoner rehabilitasyon akciğer fonksiyonlarını ve egzersiz kapasitesini iyileştirirken dispne algısını azaltır. Çalışmamızda, egzersizden elde edilen kazanımlar sayesinde hastaların yaklaşık yarısından fazlası ameliyat edilebildi. Buna göre, inoperabilite kararı almadan önce hastaları rehabilitasyona yönlendirmek yararlı olabilir.

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Cite This Article

KILIÇ, L., PEHLİVAN, E., BALCI, A. (2022). Can functional inoperability in lung cancer patients be changed by pulmonary rehabilitation?. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 27 - Sayı: 2, 212–218. https://ajindex.com/articles/423779

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References (13)

  1. Li T, He X, Chen Y. Mechanism of lung cancer and chronic obstructive pulmonary disease. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017
  2. [Abstract] 2. Trzaska-Sobczak M, Skoczyński S, Pierzchała W. Pulmonary function tests in the preoperative evaluation of lung cancer surgery c andidates. A r eview o f g uidelines. K ardiochir Torakochirurgia Pol 2014
  3. British Thoracic Society. BTS guidelines: guidelines on the selection of patients with lung cancer for surgery. Thorax 2001
  4. Colice GL, Shafazand S, Griffin JP, Keenan R, Bolliger CT. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: ACCP evidenced-based clinical practice guidelines (2nd edition). Chest 2007
  5. Brunelli A, Charloux A, Bolliger CT, Rocco G, Sculier JP, Varela G, et al. ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemoradiotherapy). Eur Respir J 2009
  6. Rocco G, Gatani T, Di Maio M, Meoli I, La Rocca A, Martucci N, et al. The impact of decreasing cutoff values for maximal oxygen consumption (VO(2)max) in the decisionmaking process for candidates to lung cancer surgery. J Thorac Dis 2013
  7. Brunelli A, Refai M, Xiumé F, Salati M, Sciarra V, Socci L, et al. Performance at symptom-limited stair-climbing test is associated with increased cardiopulmonary complications, mortality, and costs after major lung resection. Ann Thorac Surg 2008
  8. Kim ES, Kim YT, Kang CH, Park IK, Bae W, Choi SM, et al. Prevalence of and risk factors for postoperative pulmonary complications after lung cancer surgery in patients with earlystage COPD. Int J Chron Obstruct Pulmon Dis 2016
  9. Pearce A, Haas M, Viney R, Pearson SA, Haywood P, Brown C, et al. Incidence and severity of self-reported chemotherapy side effects in routine care: A prospective cohort study. PLoS One 2017
  10. e0184360. 10. Pehlivan E, Turna A, Gurses A, Gurses HN. The effects of preoperative short-term intense physical therapy in lung cancer patients: a randomized controlled trial. Ann Thorac Cardiovasc Surg 2011
  11. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J 2005
  12. Ross RM, Murthy JN, Wollak ID, Jackson AS. The six minute walk test accurately estimates mean peak oxygen uptake. BMC Pulm Med 2010
  13. Loganathan RS, Stover DE, Shi W, Venkatraman E. Prevalence of COPD