SavedAdd your journal

Journals / Cukurova Medical Journal / 2021 / Cilt: 46 - Sayı: 3

Evaluation of diagnostic accuracy tests of erythrocyte indexes in the differential diagnosis of beta thalassemia minor and iron deficiency anemia: A preliminary report

Beta talasemi minör ve demir eksikliği anemisinin ayırıcı tanısında eritrosit indekslerinin tanısal doğruluk testlerinin değerlendirilmesi: ön çalışma raporu

Tevfik BALCI
Durmuş AYAN
Cevdet TÜRKYÜREK
Ergül BAYRAM
Pages
1009–1017
Publication Date
2021-09-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There were two indices with a low performance (DOR

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: The most common anemias are iron deficiency anemia (IDA) and beta-thalassemia minor (BTm).
📊
Key Findings & Data:Materials and Methods: Total of 71 cases eligible for inclusion criteria were included in the study and 11 indices were examined. 46 of the cases were in the BTm-group and 25 of the cases were in the IDA-group.
💡
Conclusion & Impact:There were two indices with a low performance (DOR
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Eritrosit indeksleri · ayırıcı · tanı

Abstract

Purpose: The most common anemias are iron deficiency anemia (IDA) and beta-thalassemia minor (BTm). A correct differantiation of them is important in terms of preventing unnecessary iron treatment and also preventing thalassemia disease. Considering the financial limitations specifically in countries with high prevalence of thalassemia, mathematical indices, which are simpler solutions, have been used to achieve a differential diagnosis. Materials and Methods: Total of 71 cases eligible for inclusion criteria were included in the study and 11 indices were examined. 46 of the cases were in the BTm-group and 25 of the cases were in the IDA-group. The BTm-group were accepted as positive-patient-group and the IDA-group were accepted as control-group. Diagnostic criteria were evaluated with erythrocyte indices. Results: The highest Youden Index was seen in the Sirdah index (89.48%), followed by two identical performances of the Ehsani and the Mentzer indices (84.%), indicating that these three indices showed the best diagnostic performance. There were two indices with a low performance (DOR

Özet

Amaç: En sık görülen anemiler demir eksikliği anemisi (DEA) ve beta-talasemi minördür (BTm). Bunların doğru bir şekilde ayırt edilmesi, gereksiz demir tedavisinin önlenmesi ve talasemi hastalığının önlenmesi açısından önemlidir. Özellikle talasemi prevalansının yüksek olduğu ülkelerdeki finansal kısıtlılıklar göz önüne alındığında, ayırıcı tanıya ulaşmak için daha basit çözümler olan matematiksel indeksler kullanılmıştır. Gereç ve Yöntem: Dahil edilme kriterlerine uygun toplam 71 vaka çalışmaya dahil edildi ve 11 indeks incelendi. Vakaların 46'sı BTm grubunda, 25'i ise IDA grubundaydı. BTm grubu pozitif hasta grubu, DEA grubu kontrol grubu olarak kabul edildi. Tanı kriterleri eritrosit indeksleri ile değerlendirildi. Bulgular: En yüksek Youden İndeksi Sirdah indeksinde (%89,48) görüldü, ardından Ehsani ve Mentzer indekslerinin iki özdeş performansı (%84,00) bu üç indeksin en iyi tanısal performansı gösterdiğini gösteriyor. Düşük performanslı (DOR

🔖

Cite This Article

BALCI, T., AYAN, D., TÜRKYÜREK, C., BAYRAM, E. (2021). Evaluation of diagnostic accuracy tests of erythrocyte indexes in the differential diagnosis of beta thalassemia minor and iron deficiency anemia: A preliminary report. Cukurova Medical Journal, Cilt: 46 - Sayı: 3, 1009–1017. https://ajindex.com/articles/420790

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. DeLoughery TG. Microcytic anemia. N Engl J Med. 2014;371:1324-31
  2. Camaschella C. Iron deficiency. Blood. 2019;133:30- 9
  3. Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology. Guidelines for the management of iron deficiency anaemia. Gut. 2011;60:1309-16
  4. Ghosh K, Colah R, Manglani M, Choudhry VP, Verma I, Madan N et al. Guidelines for screening, diagnosis and management of hemoglobinopathies. Indian J Hum Genet. 2014;20:101-19
  5. Passarello C, Giambona A, Cannata M, Vinciguerra M, Renda D, Maggio A. Iron deficiency does not compromise the diagnosis of high HbA(2) β thalassemia trait. Haematologica. 2012;97:472-3
  6. England JM, Fraser PM. Differentiation of iron deficiency from thalassaemia trait by routine bloodcount. Lancet. 1973;1:449-52
  7. Mentzer WC Jr. Differentiation of iron deficiency from thalassaemia trait. Lancet. 1973;1:882
  8. Srivastava PC. Differentiation of thalassaemia minor from iron deficiency. Lancet. 1973;2:154-5
  9. Shine I, Lal S. A strategy to detect beta-thalassaemia minor. Lancet. 1977;1:692-4
  10. Bessman JD, Feinstein DI. Quantitative anisocytosis as a discriminant between iron deficiency and thalassemia minor. Blood. 1979;53:288-93
  11. Ricerca BM, Storti S, d'Onofrio G, Mancini S, Vittori M, Campisi S et al. Differentiation of iron deficiency from thalassaemia trait: a new approach. Haematologica. 1987;72:409-13
  12. Green R, King R. A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. Blood Cells. 1989;15:481-91; discussion 492-5
  13. Jayabose S, Mahmoud M, Levendoglu-Tugal O, Sandoval C, Ozkaynak F, Giamelli J Jr et al. Corticosteroid prophylaxis for neurologic complications of intravenous immunoglobulin G therapy in childhood immune thrombocytopenic purpura. J Pediatr Hematol Oncol. 1999;21:514-7
  14. Sirdah M, Tarazi I, Al Najjar E, Al Haddad R. Evaluation of the diagnostic reliability of different RBC indices and formulas in the differentiation of the beta-thalassaemia minor from iron deficiency in Palestinian population. Int J Lab Hematol. 2008;30:324-30
  15. Ehsani MA, Shahgholi E, Rahiminejad MS, Seighali F, Rashidi A. A new index for discrimination between iron deficiency anemia and beta-thalassemia minor: results in 284 patients. Pak J Biol Sci. 2009;12:473-5
  16. Thein SL. Molecular basis of β thalassemia and potential therapeutic targets. Blood Cells Mol Dis. 2018;70:54-65
  17. Giambona A, Passarello