Journals / Cukurova Medical Journal / 2021 / Cilt: 46 - Sayı: 4

Effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia

Hastanede yatan Covid-19 pnömoni hastalarında hipokaleminin klinik sonuçlara etkileri

Pages
1650–1656
Publication Date
2021-12-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Hypokalemia was related to metabolic alkalosis but unrelated to the duration of hospitalization, requirement of intensive care including mechanical ventilation and hospital mortality.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: We investigated the effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia.
📊
Key Findings & Data:Materials and Methods: In this single-center retrospective study, we recorded characteristics of hospitalized covid-19 pneumonia patients and laboratory test results on the first hospital day.
💡
Conclusion & Impact:Hypokalemia was related to metabolic alkalosis but unrelated to the duration of hospitalization, requirement of intensive care including mechanical ventilation and hospital mortality.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:COVİD-19 · Hipokalemi · Mortalite

Abstract

Purpose: We investigated the effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia. Materials and Methods: In this single-center retrospective study, we recorded characteristics of hospitalized covid-19 pneumonia patients and laboratory test results on the first hospital day. Duration of hospitalization, requiring intensive care including mechanical ventilation and survival, were determined. Results: Our study included 185 patients and of them 111 male (60% male) patients with mean age of 64 ± 14.5 (23-90). Patients were grouped as hypokalemic (16.8%) and normokalemic patients (83.2%). The number of diabetic patients was higher in the normokalemic group. Serum total protein and albumin levels were lower in hypokalemic group, while alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin, direct bilirubin, blood pH and bicarbonate level were higher. In multiple logistic regression analyses, alkalosis increased risk of hypokalemia 5.73 times. Duration of hospitalization, requirement of intensive care and hospital mortality were similar in hypokalemia and normokalemia patients. Conclusion: In patients with Covid-19 pneumonia, hypokalemia has been found to be quite common as high as 16.8% at the first presentation. Hypokalemia was related to metabolic alkalosis but unrelated to the duration of hospitalization, requirement of intensive care including mechanical ventilation and hospital mortality.

Özet

Amaç: Çalışmamızda hastanede yatan Covid-19 pnömonili hastalarda hipokaleminin klinik sonuçlar üzerindeki etkilerini araştırdık. Gereç ve Yöntem: Tek merkezli retrospektif çalışmada, hastanede yatan covid-19 pnömonili hastaların demografik ve klinik özellikleri ile birlikte hastanenin ilk günündeki laboratuvar sonuçları kaydedildi. Hastaların hastanede yatış süreleri, mekanik ventilasyon dahil yoğun bakım gereksinimi ve sağ kalım süreleri belirlendi. Bulgular: Çalışmamıza yaş ortalaması 64 ± 14.5 (23-90) olan 111 erkek (% 60) olmak üzere 185 hasta dahil edildi. Hastalar hipokalemik (%16.8) ve normokalemik (%83.2) olarak 2 gruba ayrıldı. Diyabetik hasta sayısı normokalemik grupta daha fazlaydı. Hipokalemik grupta serum total protein ve albümin düzeyleri daha düşük, alkalen fosfataz, gama-glutamil transpeptidaz, total bilirubin, direkt bilirubin, kan pH'sı ve bikarbonat düzeyi daha yüksekti. Çoklu lojistik regresyon analizinde alkaloz hipokalemi riskini 5.73 kat artırdı. Hastanede yatış süresi, yoğun bakım gereksinimi ve hastane mortalitesi hipokalemi ve normokalemi hastalarında benzerdi. Sonuç: Covid-19 pnömoni hastalarında ilk başvuruda hipokalemi %16.8 gibi oldukça yüksek oranda bulunmuştur. Hipokalemi metabolik alkaloz ile ilişkiliydi ancak hastanede kalış süresi, mekanik ventilasyon dahil yoğun bakım gereksinimi ve hastane mortalitesi ile ilişkili değildi.

🔖

Cite This Article

KAYA, B., PAYDAS, S., KUZU, T., DEMİROGLU, O., KARAKAYA, S. P. Y., BALAL, M., TAŞOVA, Y. (2021). Effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia. Cukurova Medical Journal, Cilt: 46 - Sayı: 4, 1650–1656. https://ajindex.com/articles/420756

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-ınfected pneumonia. N Engl J Med. 2020;382:1199-207
  2. Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W et al. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses. 2020;12:372
  3. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271-80e8
  4. Machhi J, Herskovitz J, Senan AM, Dutta D, Nath B, Oleynikov MD et al. The natural history, pathobiology, and clinical manifestations of SARSCoV-2 infections. J Neuroimmune Pharmacol. 2020;15:359-86
  5. Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Singlecell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020;14:185-92
  6. Liu J, Liu S. The management of coronavirus disease 2019 (COVID-19). J Med Virol. 2020;92:1484-90
  7. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A et al. Baseline characteristics and outcomes of 1591 patients ınfected with SARS-CoV2 admitted to ICUs of the Lombardy region, Italy. JAMA. 2020;323:1574-81
  8. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020;323:2052-9
  9. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708-20
  10. Garg S, Kim L, Whitaker M, O'Halloran A, Cummings C, Holstein R et al. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019 - COVID-NET, 14 States, March 1-30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:458-64
  11. Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L et al. Features of 20 133 UK patients in hospital with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020; 369:m1985
  12. Copaescu A, Smibert O, Gibson A, Phillips EJ, Trubiano JA. The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection. J Allergy Clin Immunol. 2020;146:518-34 e511
  13. Li H, Liu L, Zhang D, Xu J, Dai H, Tang N et al. SARS-CoV-2 and viral sepsis: obse