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Journals / Düzce Tıp Fakültesi Dergisi / 2005 / Cilt: 7 - Sayı: 3

The Role of Free Radıcals and the Effect of Antıoxidants in Dıiabetes

Diyabette Serbest Radikallerin Rolü ve Antioksidanların Etkisi

Ramazan MEMİŞOĞULLARI
Pages
30–39
Publication Date
2005-12-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The role of oxidative stress in diabetes and the effect of antioxidants have been examined in this review

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Diabetes is a chronic metabolism disorder with increasing prevalence worldwide.
📊
Key Findings & Data:Many mechanisms have been suggested in the pathogenesis of diabetes and its complications.
💡
Conclusion & Impact:The role of oxidative stress in diabetes and the effect of antioxidants have been examined in this review
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Diyabet · diyabet komplikasyonları · serbest radikaller

Abstract

Diabetes is a chronic metabolism disorder with increasing prevalence worldwide. Many mechanisms have been suggested in the pathogenesis of diabetes and its complications. The most accepted mechanism is that free radicals are the main cause of the complications. Oxidative stress can be managed by increasing antioxidant capacity in diabetes. The role of oxidative stress in diabetes and the effect of antioxidants have been examined in this review

Özet

Diyabet tüm dünyada görülme sıklığı hızla artmakta olan kronik bir metabolizma bozukluğudur. Diyabetin ve komplikasyonlarının patogenezinde pek çok mekanizma ileri sürülmüştür. Bunlar içinde en fazla kabul göreni ise artan serbest radikallerin komplikasyonlara neden olmasıdır. Diyabette oluşan oksidatif stresle, antioksidan kapasiteyi arttırarak başa çıkılabilir. Bu derlemede oksidatif stresin diyabetteki rolü ve antioksidanların bu stresle başa çıkabilmedeki etkisi irdelenmektedir

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Cite This Article

MEMİŞOĞULLARI, R. (2005). The Role of Free Radıcals and the Effect of Antıoxidants in Dıiabetes. Düzce Tıp Fakültesi Dergisi, Cilt: 7 - Sayı: 3, 30–39. https://ajindex.com/articles/420656

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References (12)

  1. Vincent AM, Russell JW, Low P, Feldman EL: Oxidative Stress in the Pathogenesis of Diabetic Neuropathy. Endocrine Reviews. 25: 612–628, 2004.
  2. Memisogullari R, Taysi S, Bakan E, Capoglu I: Antioxidant Status and Lipid Peroxidation in Type II Diabetes Mellitus. Cell Biochem Func. 21: 291-296, 2003. Sacks DB: Diabetes Mellitus. In: Burtis CA, Ashwood ER, (Ed). Tietz Texbook of clinical chemistry. Philadelphia: WB Saunders Co: 766- 776, 1999.
  3. Cherubini A, Ruggiero C, Polidori MC, Mecocci C: Potential markers of oxidative stress in stroke. Free Radical Biology & Medicine. 39: 841 – 852, 2005.
  4. Memişoğulları R, Bakan E: Levels of ceruloplasmin, transferrin, and lipid peroxidation in the serum of patients with Type 2 diabetes mellitus. Journal of Diabetes and Its Complications. 18: 193– 197, 2004.
  5. Young IS, Woodside JV. Antioxidants in health and disease. J Clin Pathol 54:176-186, (2001) Sözmen EY: Yaşlanma Biyokimyası. In Onat T, Emerk K, Sözmen EY (Eds) İnsan Biyokimyası, Palme Yayıncılık, Ankara pp: 665-674. 2002. Pratic`o D: Antioxidants and endothelium protection. Atherosclerosis. 181: 215–224, 2005. Alper G. Diyabet. In: Onat T, Emerk K, Sözmen EY, (eds). İnsan Biyokimyası. Ankara, Palme Yayıncılık, pp: 248-257, 2002.
  6. Ostenson, C. G: The pathophysiology of type 2 diabetes mellitus: an overview. Acta Physiologica Scandinavica. 171: 241– 247, 2001.
  7. Akçay F, Aksoy H, Memişoğulları R: Effect of breast-feeding on concentration of nitric oxide in breast milk. Ann Clin Biochem. 39: 68-69, 2002.
  8. Abou-Seif MA, Youssef A. Evaluation of some biochemical changes in diabetic patients. Clinica Chimica Acta 346 (2004) 161–170
  9. Daimon M, Hama K, Susa S, Kimura M, Yamatani K, Ohnuma H, Manaka H, Kato T. Hyperglycemia is a factor for an increase in serum ceruloplasmin in type 2 diabetes. Diabetes Care 21:1525-1528, (1998)
  10. Niki E, Yoshida Y, Saito Y, Noguchi N: Lipid peroxidation: Mechanisms, inhibition, and biological effects. Biochemical and Biophysical Research Communications. 338: 668–676, 2005.
  11. Şekeroğlu MR, Şahin H, Dülger H, Algün E: The effect of dietary treatment on erythrocyte lipid peroxidation, superoxide dismutase, glutathione peroxidase, and serum lipid peroxidation in patients with type 2 diabetes mellitus. Clin Biochem. 33:669-674, 2000.
  12. Masella R, Benedetto RD, Varı R, Filesi C, Giovannini C: Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione- related enzymes. Journal of Nutritional Biochemistry.