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Journals / Düzce Tıp Fakültesi Dergisi / 2005 / Cilt: 7 - Sayı: 3

Report of Two Cases of Kocher-Debre Semelaigne Syndrome

Kocher-Debre Semelaigne Sendromlu İki Olgu Sunumu

Hakan UZUN
Şeref TARGAN
Özlem ÇORUMLU
Alev Aktaş Füsun ATLIHAN
Pages
25–27
Publication Date
2005-12-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We aimed to emphasize the effects of hypothyroidism on muscle tissue

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Myopathy associated with hypothyroidism classically presents with proximal weakness, fatigue, exertional pain, slowed movement, myoedema, diminished deep tendon reflexes, stiffness, myalgia, less commonly cramps and rarely muscle enlargement.
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Key Findings & Data:We report ed here two brothers at the ages of 11 and 7 year-old diagnosed as KDS syndrome.
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Conclusion & Impact:We aimed to emphasize the effects of hypothyroidism on muscle tissue
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hipotiroidi · miyopati · çocuk

Abstract

Myopathy associated with hypothyroidism classically presents with proximal weakness, fatigue, exertional pain, slowed movement, myoedema, diminished deep tendon reflexes, stiffness, myalgia, less commonly cramps and rarely muscle enlargement. Muscle enlargement and hypothroidism is known as Kocher-Debre Semelaigne syndrome (KDS). We report ed here two brothers at the ages of 11 and 7 year-old diagnosed as KDS syndrome. We aimed to emphasize the effects of hypothyroidism on muscle tissue

Özet

Hipotroidi ile ilişkili miyopati klasik olarak, proksimal kas güçsüzlüğü, yorgunluk, egzersiz ağrısı, hareketlerde yavaşlama, kas ödemi, derin tendon reflekslerinde azalma, kaslarda sertleşme, ağrı daha nadir olarakta kramp ve kasın büyümesi şeklinde kendini gösterir. Kasın büyümesi Kocher-Debre Semelaigne sendromu (KDS) olarak bilinir. Biz burada 11 ve 7 yaşlarında KDS sendromlu iki erkek kardeş olguyu sunarak hipotroidinin kas dokusu üzerindeki etkilerini vurgulamayı amaçladık

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Cite This Article

UZUN, H., TARGAN, Ş., ÇORUMLU, Ö., ATLIHAN, A. A. F. (2005). Report of Two Cases of Kocher-Debre Semelaigne Syndrome. Düzce Tıp Fakültesi Dergisi, Cilt: 7 - Sayı: 3, 25–27. https://ajindex.com/articles/420655

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References (12)

  1. Kung AWC, Ma JTC, Yu YL: Myopathy in acute hypothyroidism. Post Med j 63:661- 663,1987
  2. Lochmüller H, Reimers CD, Fischer P: Exercise induced myalgia in hypothyroidism. Clin Invest. 17: 1697-1700,1993
  3. Mehrtra P, Chandra M, Mitra MK: Kocher Debre Semelaigne syndrome: regression of pseudohypertrophy of muscles on thyroxine. Arch Dis Child. 86: 224,2002
  4. Klein I, Levey G: Unusual manifestations of hypothyroidism. Arch Intern Med. 144:123- 128,1984
  5. Klein I, Mantell P, Parker M, Levey GS: Resolution of abnormal muscle enzyme studies in hypothroidism. Am J Med Sci. 279:159-162,1980
  6. Thasko V, Davachi F, Baboci R, Drishti G, Hoxha P: Kocher-Debre Semelaigne syndrome. Clin Pediatr (Phila). 38:113- 115,1999
  7. Monzani F, Caraccio N, Siciliano G, Manca L, Murri L, Ferrannini E. Clinical and biochemical features of muscle dysfunction in subclinical hypothyroidism. J Clin Endocrinol Metab. 82: 3315-3318,1997
  8. Siciliano G, Monzani F, Manca ML, Tessa A, Caraccio N, Tozzi G, Piemonte F, Mancuso M, Santorelli FM, Ferrannini E, Murri L: Human mitochondrial transcription factor A reduction and mitochondrial dysfunction in Hashimoto's hypothyroid myopathy. Mol Med 8: 326- 333,2002
  9. Ghilardi G, Gonvers JJ, So A: Hypothyroid myopathy as a complication of interferon alpha therapy for chronic hepatitis C virus infection. Br J Rheumatol. 37:1349-1351,1998
  10. Mastropasqua M, Spagna G, Baldini V, Tudesco I, Paggi A: Hoffman’s syndrome: muscle stiffness, pseudohypertrophy and hypothyroidism. Horm Res. 59:105-108,2003
  11. Ruurd FD, Bosch J, Laman DM: Neuromuscular findings in thyroid dysfunction aprospective clinical andelectrodiagnostic study. J Neurol Neurosurg Psychiatry. 68:750-755,2000
  12. Najjar SS: Muscular hypertrophy in hypothyroid children: The Kocher-Debre-Semelaigne Syndrome. J Ped 85:236-239,1974.