Journals / Düzce Tıp Fakültesi Dergisi / 2005 / Cilt: 7 - Sayı: 1

Evaluation of Serum Anti-Neutrophil Cytoplasmic Antibody in Patients With Behçet’s Disease

Behçet Hastalarında Serum Anti-Nötrofil Sitoplazmik Antikor Varlığının Araştırılması

Pages
15–18
Publication Date
2005-03-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, although Behçet’s disease mimics to some ANCA positive vasculitis, our results support the theory that ANCA does not have a role in the pathogenesis of Behçet’s disease

📌 3 Key Takeaways

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Objective & Hypothesis:Behçet’s disease is a chronic illnes with unknown etiology and associated with oral aphtae, genital ulceration and uveitis.
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Key Findings & Data:This study was performed on 32 patients , 21 female and 11 male, who are between 20-59 year old and attended to the Ministry of Health, Ankara Training and Research Hospital Department of Dermatology between June 2002 and January 2003.
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Conclusion & Impact:As a result, although Behçet’s disease mimics to some ANCA positive vasculitis, our results support the theory that ANCA does not have a role in the pathogenesis of Behçet’s disease
🔬Design:Research Article
📍Scope:2002 Verileri
⚙️Variables:Behçet hastalığı · ANCA · Behçet’s disease

Abstract

Behçet’s disease is a chronic illnes with unknown etiology and associated with oral aphtae, genital ulceration and uveitis. In this study ANCA positivity which was previously reported in some patients, was investigatedin patients with Behçet’s disease. This study was performed on 32 patients , 21 female and 11 male, who are between 20-59 year old and attended to the Ministry of Health, Ankara Training and Research Hospital Department of Dermatology between June 2002 and January 2003. Diagnosis was made according to the International Study Group Criteria. Serum c-ANCA and p-ANCA were negative in all patients. As a result, although Behçet’s disease mimics to some ANCA positive vasculitis, our results support the theory that ANCA does not have a role in the pathogenesis of Behçet’s disease

Özet

Behçet hastalığı; ağızda aft, genital ülserasyon ve üveitle birlikte seyreden, etyolojisi bilinmeyen, kronik bir hastalıktır. Bu çalışmada, Behçet hastalarında daha önce bazı vakalarda bildirilen ANCA pozitifliği araştırıldı. Çalışma, Haziran 2002 - Ocak 2003 tarihleri arasında S.B. Ankara Eğitim ve Araştırma Hastanesi Dermatoloji Polikliniğine başvuran 21’i kadın, 11’i erkek, yaşları 20-59 yıl arasında değişen, 32 Behçet hastası ile gerçekleştirildi. BH tanısı, Uluslararası Çalışma Grubu Tanı Kriterlerine göre kondu. Ölçümlerde tüm hastalarda serum c-ANCA ve p-ANCA’nın negatif olduğu saptandı. Sonuç olarak Behçet hastalığı, ANCA pozitifliği gösteren vaskülitlerle benzerlik göstermesine rağmen, bu çalışma Behçet hastalığının patogenezinde ANCA’nın rolü olmadığı görüşünü desteklemektedir

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Cite This Article

POLAT, M. U., VAHABOĞLU, G., EKŞİOĞLU, M., ÖNDE, U. (2005). Evaluation of Serum Anti-Neutrophil Cytoplasmic Antibody in Patients With Behçet’s Disease. Düzce Tıp Fakültesi Dergisi, Cilt: 7 - Sayı: 1, 15–18. https://ajindex.com/articles/420290

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References (9)

  1. Lesavre P. ANCA; diversity and clinical applications. Advances Nephrol. 22:237-67, 1993.
  2. Jennette JC, Wilkmann AS, Falk RJ. Antineutrophil cytoplasmic autoantibody- associated glomerulonephritis and vasculitis. Am J Pathol, 135(5):921-30, 1989.
  3. Cohen Terveart JW, Huitema MG, Hene RJ, et all. Prevention of relapses in Wegener’s granulomatosis by treatment based on antineutrophil cytoplasmic antibody titre. Lancet. 336: 709-11, 1990.
  4. Jennette JC, Falk RJ. Antineutrophil cytoplasmic autoantibodies and associated diseases: A review. Am J Kidney Dis. 15(6): 517-29, 1990.
  5. Rump JA, Schölmerich J, Gross V, Roth M, Helfesrieder R, Rautmann A, Ludemann J, et all. A new type of perinuclear antineutrophil cytoplasmic antibody (p-ANCA) in active ulserative colitis but not in Crohn’ disease. Immunobiology. 181(4-5):406-13, 1990.
  6. Gross WF, Schmitt WH, Csernok E. ANCA and associated diseases: Immunodiagnostic and pathogenetic aspects. Clin Exp Immunol. 91(1):1-12, 1993.
  7. Hagen EC, Ballieux BE, van ES LA, Daha MR, van der Woude FJ. Antineutrophil cytoplasmic antibodies: A review of the antigens involved, the assays and the clinical possible pathogenetic consequences. Blood. 15; 81(8):1996-2002, 1993.
  8. Gispert JP, Luna M, Legido J, Hermida C, Mate J, Pajares JM. Anti-neutrophil cytoplasmic antibodies in the diagnosis of ulcerative colitis and Crohn’s disease. Med Clin. 122(4):134-5, 2004.
  9. Efthimiou J, Spickett G, Lane D, Thompson A. Antineutrophil cytoplasmic antibodies, cystic fibrosis and infection. Lancet. 1:1037-8, 1991. Jorizzo JL. Behçet’sdisease. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Kat SI, Fitzpatrick TB, editors. Dermatology in General Medicine. 5th ed. New York: McGraw- Hill Company, pp: 2161-5, 1999. 11- Jayashri VG, Jorizzo JL. Behçet’s disease and complex aphthosis. J Am Acad Dermatol. 40: 1- 18, 1999. 12- Direskeneli H. Behçet’s disease: infectious aetiology, new autoantigens and HLA-51. Ann Rheum Dis. 60: 996-1002, 2001. 13- Behçet H. Uber rezidivivierende aphthose, durch ein virus verursachte geschwure am mund, am auge und an den genitalien. Dermatol Wochenschr. 105: 1152-7, 1937. 14- Charles LA, Caldas ML, Falk RJ, Terrell RS, Jennette JC. Antibodies againts granule proteins activate neutrophils in vitro. J Leukoc Biol. 50(6):539-46, 1991. 15- Specks U, Wiegert EM, Homburger HA. Human mast cell expressing recombinant proteinase 3 (PR3) as substrate for clinical testing for anti-neutrophil cytoplasmic antibodies (ANCA). Clin Exp Immuno