SavedAdd your journal

Journals / Düzce Tıp Fakültesi Dergisi / 2013 / Cilt: 15 - Sayı: 1

Annexin A2, A7 and A11 Immunohistochemical Expression in Prostate Adenocarcinoma and Relationship with Prognostic Factors

Prostat Adenokarsinomlarında Annexin A2, A7 Ve A11 İmmünhistokimyasal Ekspresyonu ve Prognostik Faktörlerle İlişkisi

Aynur Albayrak SÖNMEZ
Berrak Gümüşkaya ÖCAL
Sema HÜCÜMENOĞLU
Murat ALPER
Murat OKTAY
Pages
14–18
Publication Date
2013-03-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Annexin A2 can used as immunohistochemical helper in differential diagnosisbetween normal and carcinomatous tissues on biopsy

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: The role of calcium dependent phospholipase binding protein family membersAnnexin A2, A7 and A11 in the development and progression of prostate cancer was explored.Methods: Protein expressions of Annexin A2, A7 and A11 were examined byimmunohistochemistry in 53 clinicopathologically characterized prostate cancer and peritumoralareas.
📊
Key Findings & Data:Difference between cancer and normal tissues was evaluated and relationship withprognostic factors was determined.Results: The expression of Annexin A2, A7 and A11, effect regulation of membrane functions,cellular homeostasis, and proliferation, were down-regulated in prostate cancer compared withadjacent non-cancerous tissues ( respectively p=0,022; 0,028; 0,033).
💡
Conclusion & Impact:Annexin A2 can used as immunohistochemical helper in differential diagnosisbetween normal and carcinomatous tissues on biopsy
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Prostat adenokarsinomu · Annexin A2 · Annexin A7

Abstract

Purpose: The role of calcium dependent phospholipase binding protein family membersAnnexin A2, A7 and A11 in the development and progression of prostate cancer was explored.Methods: Protein expressions of Annexin A2, A7 and A11 were examined byimmunohistochemistry in 53 clinicopathologically characterized prostate cancer and peritumoralareas. Difference between cancer and normal tissues was evaluated and relationship withprognostic factors was determined.Results: The expression of Annexin A2, A7 and A11, effect regulation of membrane functions,cellular homeostasis, and proliferation, were down-regulated in prostate cancer compared withadjacent non-cancerous tissues ( respectively p=0,022; 0,028; 0,033). Expression of annexina2, a7 and a11 did not correlate with age, stage, invasion of capsule and perineural tissue.Conclusion: the decrease of expression of Annexin A2, A7 and A11 protein in prostateadenocarcinoma can associate with acquired capability of invasion and loss of differentiationof tumor cells. Annexin A2 can used as immunohistochemical helper in differential diagnosisbetween normal and carcinomatous tissues on biopsy

Özet

Amaç: Bu çalışmada kalsiyum bağımlı fosfolipid bağlayan proteinler olan Annexin ailesininüyelerinden Annexin A2, A7 ve A11’in prostat adenokarsinomu gelişimi ve ilerlemesi üzerindekirolü araştırıldı.Yöntem: 53 adet prostat adenokarsinomu olgusunda çevre normal doku ve karsinom dokularınıniyi temsil edildiği kesitlerde immünhistokimyasal olarak Annexin A2, A7 ve A11 ekspresyonu,çevre normal dokudan farkı ve tümör evresi, tümör derecesi ve diğer prognostik kriteler ileilişkisi değerlendirildi.Bulgular: Hücre homeostasisinde, membran fonksiyonlarının düzenlenmesinde ve hücreçoğalmasında etkileri olduğu bilinen Annexin A2, A7 ve A11’in normal prostat dokularındagüçlü sitoplazmik ekspresyon gösterdiği ancak prostat adenokarsinomlarında, tümörsüz çevredokuya oranla anlamlı olarak azalmış ekspresyon gösterdiği saptanmıştır ( sırası ile p=0,022;0,028; 0,033) . Gleson skor, yaş, evre, kapsül invazyonu ve perinöral invazyon ile anlamlı ilişkibulunmamıştır.Sonuç: Prostat adenokarsinom hücrelerinde gözlenen Annexin A2, A7, A11 ekspresyonazalmasının, tümör hücrelerinin diferansiasyon kaybı ve invazyon yeteneği kazanması ile ilişkiliolduğu düşünülmüştür. Ayrıca özellikle Annexin A2’nin prostat adenokarsinomunun normaldokudan ayırıcı tanısında immunhistokimyasal bir yardımcı olarak kullanılabileceğibelirlenmiştir

🔖

Cite This Article

SÖNMEZ, A. A., ÖCAL, B. G., HÜCÜMENOĞLU, S., ALPER, M., OKTAY, M. (2013). Annexin A2, A7 and A11 Immunohistochemical Expression in Prostate Adenocarcinoma and Relationship with Prognostic Factors. Düzce Tıp Fakültesi Dergisi, Cilt: 15 - Sayı: 1, 14–18. https://ajindex.com/articles/420199

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Gerke V, Creutz CE, Moss SE. Annexins: linking Ca2+ signalling to membrane dynamics. Nat Rev Mol Cell Biol 2005; 6(6): 449–461.
  2. Frohlich M, Motte P, Galvin K, Takahashi H, Wands J, Ozturk M. Enhanced expression of the protein kinase substrate p36 in human hepatocellular carcinoma. Mol Cell Biol 1990; 10(6): 3216–3223.
  3. Dreier R, Schmid KW, Gerke V, Riehemann K. Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study. Histochem Cell Biol 1998; 110(2): 137–148.
  4. Massey-Harroche D, Mayran N, Maroux S. Polarized localizations of annexins I, II, VI and XIII in epithelial cells of intestinal, hepatic and pancreatic tissues. J Cell Sci 1998; 111(Part 20): 3007– 3015. Chetcuti A, Margan SH, Russell P, Mann S, Millar DS, Clark SJ, Rogers J, Handelsman DJ, Dong Q. Loss of annexin II heavy and light chains in prostate cancer and its precursors. Cancer Res 2001; 61(17): 6331– 6334. Banerjee AG, Liu J, Yuan Y, Gopalakrishnan VK, Johansson SL, Dinda AK, Gupta NP, Trevino L, Vishwanatha JK. Expression of biomarkers modulating prostate cancer angiogenesis: differential expression of annexin II in prostate carcinomas from India and USA. Mol Cancer 2003; 2: 34. Liu JW, Shen JJ, Tanzillo-Swarts A, et al. Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration. Oncogene 2003; 22(10): 1475–1485.
  5. Gillette JM, Chan DC, Nielsen-Preiss SM. Annexin 2 expression is reduced in human osteosarcoma metastases. J Cell Biochem 2004; 92(4): 820–832
  6. Zhi H, Zhang J, Hu G, Lu J, Wang X, Zhou C, Wu M, Liu Z. The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma. Int J Cancer 2003; 106(3): 327–333
  7. Pena-Alonso E, Rodrigo JP, Parra IC, et al. Annexin A2 localizes to the basal epithelial layer and is down-regulated in dysplasia and head and neck squamous cell carcinoma. Cancer Lett 2008, 263(1): 89–98.
  8. Yee D, Narula N, Ramzy I et al. Ornstein, MD. Reduced Annexin II Protein Expression in High-Grade Prostatic Intraepithelial Neoplasia and Prostate CancerArch Pathol Lab Med 2007, 131, 902-908.
  9. Raynal P, Pollard HB: Annexins: The problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins. Biochim Biophys Acta 1994, 1197:63–93.
  10. Nir S, Stutzin A, Pollard HB: Effect of synexin on aggregation and fusion of chromaffin granule ghosts at pH 6. Biochim Biophys Acta 1987, 903:309–318. Poll