SavedAdd your journal

Journals / Düzce Tıp Fakültesi Dergisi / 2020 / Cilt: 22 - Sayı: 3

Evaluation of the Relationship between Silent Cerebral Lesions and Triglyceride/HDL-Cholesterol in Patients with First Stroke Attack

İlk İnme Atağı Olan Olgularda Sessiz Serebral Lezyonların Trigliserid/HDL-Kolesterol Oranı ile İlişkisinin Değerlendirilmesi

Esra ACİMAN DEMİREL
Gülcan KALAYCI
Mustafa AÇIKGÖZ
Ulufer ÇELEBİ
Bilge CİNAR
Hüsyin Tuğrul ATASOY
Pages
191–195
Publication Date
2020-12-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

With this simple, inexpensive and effective test method, high-risk group of LA and SCI could be identified.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is defined as the serum atherogenicity index.
📊
Key Findings & Data:Material and Methods: We retrospectively evaluated 200 patients who admitted to Bulent Ecevit University Faculty of Medicine, Department of Neurology with the diagnosis of acute first ischemic stroke.
💡
Conclusion & Impact:With this simple, inexpensive and effective test method, high-risk group of LA and SCI could be identified.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Sessiz serebral iskemi · lökoariozis · TG/HDL-K oranı

Abstract

Aim: Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is defined as the serum atherogenicity index. High TG/HDL-C ratio is related with vascular diseases, insulin resistance and metabolic syndrome. The TG/HDL-C ratio in cerebrovascular diseases, especially in silent cerebral lesions hasn’t been well studied. The aim of this study was to evaluate the frequency of silent cerebral ischemia (SCI) and leukoaraiosis (LA), and its relationship with TG/HDL-C ratio in patients admitted with the first ischemic stroke attack. Material and Methods: We retrospectively evaluated 200 patients who admitted to Bulent Ecevit University Faculty of Medicine, Department of Neurology with the diagnosis of acute first ischemic stroke. Silent cerebral lesions were defined as LA and SCI with magnetic resonance imaging. TG/HDL-C ratio was calculated by dividing TG levels by HDL-C levels. Results: Silent cerebral lesions were detected 124 (83.2%) of 149 patients. LA severity was evaluated according to Fazekas score, 22 (14.8%) of patients were grade 0, 49 (32.9%) of them were grade 1, and 78 (52.3%) of them were advanced periventricular white matter hyperintensity (adv-PWMH) group. TG/HDL-C ratio in SCI group was higher than the group without SCI, but it wasn’t statistically significant (p=0.091). A significant increase was observed in the TG/HDL-C ratio, as LA severity increased. TG/HDL-C ratio was significantly higher in adv-PWMH group (p=0.050). Conclusion: High serum atherogenicity index is associated with atherosclerosis and vascular endothelial dysfunction. With this simple, inexpensive and effective test method, high-risk group of LA and SCI could be identified.

Özet

Amaç: Trigliserid/yüksek yoğunluklu lipoprotein kolesterol (TG/HDL-K) oranı serum aterojenite indeksi olarak tanımlanmıştır. Yüksek TG/HDL-K oranı vasküler hastalıklar, insülin direnci ve metabolik sendrom ile ilişkilidir. Serebrovasküler olaylarda özellikle sessiz serebral lezyonlarda TG/HDL-K oranı ile ilgili çalışmalar azdır. Bu çalışmanın amacı, ilk iskemik inme atağı ile başvuran hastalarda sessiz serebral iskemi (SSİ) ve lökoariozis (LA) sıklığını ve TG/HDL-K oranı ile ilişkisini değerlendirmektir. Gereç ve Yöntemler: Bülent Ecevit Üniversitesi Tıp Fakültesi Nöroloji bölümüne akut ilk iskemik inme tanısı ile başvuran 200 hasta geriye dönük olarak değerlendirildi. Manyetik rezonans görüntüleme ile sessiz serebral lezyonlar SSİ ve LA olarak tanımlandı. TG/HDL-K oranı TG değerinin HDL-K değerine bölünmesi ile hesaplandı. Bulgular: Yüz kırk dokuz hastanın 124 (%83,2)’ünde sessiz serebral lezyon saptandı. LA şiddeti Fazekas skorlamasına göre değerlendirildi, hastaların 22 (%14,8)’si grade 0, 49 (%32,9)’u grade 1 ve 78 (%52,3)’i ileri düzey periventriküler beyaz cevher lezyonu (advanced periventricular white matter hyperintensity, adv-PWMH) grubundaydı. SSİ grubunda TG/HDL-K oranı SSİ olmayan gruba göre daha yüksek bulundu, ancak istatistiksel olarak anlamlı değildi (p=0,091). LA şiddeti arttıkça TG/HDL-K oranında anlamlı bir artış olduğu izlendi. TG/HDL-K oranı, adv-PWMH grubunda anlamlı derecede yüksek idi (p=0,050). Sonuç: Yüksek serum aterojenite indeksi ateroskleroz ve vasküler endotelyal disfonksiyon ile ilişkilidir. Bu basit, ucuz ve etkili test yöntemi ile LA ve SSİ yüksek risk grubu belirlenebilir.

🔖

Cite This Article

DEMİREL, E. A., KALAYCI, G., AÇIKGÖZ, M., ÇELEBİ, U., CİNAR, B., ATASOY, H. T. (2020). Evaluation of the Relationship between Silent Cerebral Lesions and Triglyceride/HDL-Cholesterol in Patients with First Stroke Attack. Düzce Tıp Fakültesi Dergisi, Cilt: 22 - Sayı: 3, 191–195. https://ajindex.com/articles/420117

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Donkor ES. Stroke in the 21st century: A snapshot of the burden, epidemiology, and quality of life. Stroke Res Treat. 2018;2018:3238165. Bradley WG, Daroff RB, Fenichel GM, Jankovic J. Neurology in Clinical Practice. Çeviri: Tan E, Erdem Özdamar S. Ankara: Veri Medikal Yayıncılık; 2008. p.1165-1170.
  2. Vermeer SE, Longstreth WT Jr, Koudstaal PJ. Silent brain infarcts: systematic review. Lancet Neurol. 2007;6(7):611-9.
  3. Oh SH, Kim NK, Kim SH, Kim JK, Kim HS, Kim WC, et al. The prevalence and risk factor analysis of silent brain infarction in patients with first-ever ischemic stroke. J Neurol Sci. 2010;293(1-2):97-101.
  4. Ay H, Arsava EM, Rosand J, Furie KL, Singhal AB, Schaefer PW, et al. Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke. Stroke 2008;39(5):1409-13.
  5. Ovbiagele B, Saver JL. Cerebral white matter hyperintensities on MRI: current concepts and therapeutic implications. Cerebrovasc Dis. 2006;22(2-3):83-90.
  6. Acıman Demirel E, Emre U, Ünal A, Özen B, Atasoy HT, Öztürk F. Evaluation of silent cerebral lesions in patients with first ischemic stroke attack. Neurol Psychiat Br. 2012;18(1); 22-6.
  7. Inoue K, Matsumoto M, Shono T, Toyokawa S, Moriki A. Increased intima media thickness and atherosclerotic plaques in the carotid artery as risk factors for silent brain infarcts. J Stroke Cerebrovasc Dis. 2007;16(1):14-20.
  8. Nam KW, Kwon HM, Jeong HY, Park JH, Kwon H, Jeong SM. High triglyceride/HDL cholesterol ratio is associated with silent brain infarcts in a healthy population. BMC Neurol. 2019;19(1):147. Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. 2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2018;49(3):e46-110. da Luz PL, Favarato D, Faria-Neto JR Jr, Lemos P, Chagas AC. High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease. Clinics (Sao Paulo). 2008;63(4):427-32.
  9. Söğüt E, Avcı E, Üstüner F, Arıkan E. The evaluation of (TG/HDL-C) ratio as a serum atherogenic index. Türk Klinik Biyokimya Derg. 2006;4(1):1-8.
  10. Pacifico L, Bonci E, Andreoli G, Romaggioli S, Di Miscio R, Lombardo CV, et al. Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents. Nutr Metab Cardiovasc Dis. 2014;24(7):737-43. Hermans MP,