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Journals / 7tepe Klinik / 2019 / Cilt: 15 - Sayı: 1

The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats

Osteoporotik sıçanlarda tek yüksek doz D-vitamini enjeksiyonunun kondil kırığı iyileşmesine etkisi

Akif TURER
Osman KELAHMETOGLU
Deniz Gokce MERAL
Uğur MERCAN
Yonca Betil KABAK
Pages
70–76
Publication Date
2022-09-03
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

TGFβ1 and osteopentin levels in group D were found higher than group C.Conclusion: We have determined that a single high-dose injection of vitamin D given immediately after surgery increasedTGFβ and osteopontin levels and enhanced new bone formation at condylar fractures of osteoporotic rats.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: In this study we have tried to show the effects of a singlehigh-dose ınjection of vitamin d on healing of condylar fractures in osteoporotic rats.Materials and method: This study included sixteen femalewistar rats.
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Key Findings & Data:Group D animals received a single high dose of vitamin D (50.000 IU/kg) intraperitoneally and group C (control)animals received saline (0.05 mL) intraperitoneally.
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Conclusion & Impact:TGFβ1 and osteopentin levels in group D were found higher than group C.Conclusion: We have determined that a single high-dose injection of vitamin D given immediately after surgery increasedTGFβ and osteopontin levels and enhanced new bone formation at condylar fractures of osteoporotic rats.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: In this study we have tried to show the effects of a singlehigh-dose ınjection of vitamin d on healing of condylar fractures in osteoporotic rats.Materials and method: This study included sixteen femalewistar rats. All rats were overiectomized. Osteoporotic ratswere randomly divided into two groups of eight animals/group. Group D animals received a single high dose of vitamin D (50.000 IU/kg) intraperitoneally and group C (control)animals received saline (0.05 mL) intraperitoneally. All injections were given immediately after condylar fracture. All ratswere euthanized after 28 days, examined histopathologicaland immunohistochemical.Results: Histopathological and immunohistochemical evaluations were done. Histopathological scores between groupD and C were found statistically significant. TGFβ1 and osteopentin levels in group D were found higher than group C.Conclusion: We have determined that a single high-dose injection of vitamin D given immediately after surgery increasedTGFβ and osteopontin levels and enhanced new bone formation at condylar fractures of osteoporotic rats.

Özet

Amaç: Bu çalışmada, osteoporotik sıçanlarda kondiler kırıkların iyileşmesinde tek yüksek doz verilen D vitamininin etkilerini göstermeye çalıştık. Gereç ve Yöntem: Bu çalışmada 16 dişi wistar sıçanı kullanıldı. Tüm sıçanlara overiektomi uygulandı. Osteoporotik sıçanlar rastgele her grupta sekiz hayvan olacak şekilde iki gruba ayrıldı. Grup D hayvanlarına intraperitoneal olarak tek doz D vitamini (50,000 IU / kg) verildi ve grup C (kontrol) hayvanlara intraperitoneal olarak serum fizyolojik (0,05 mL) verildi. Tüm enjeksiyonlar, kondiler kırıktan hemen sonra yapıldı. Bütün sıçanlar 28 gün sonra sakrifiye edildi, Histopatolojik ve immünohistokimyasal olarak incelendi. Bulgular: Histopatolojik ve immünohistokimyasal değerlendirmeler yapıldı. D ve C grubu arasındaki histopatolojik veriler istatistiksel olarak anlamlı bulundu. Grup D' de TGFβ1 ve osteopentin düzeyleri C grubundan daha yüksek bulundu. Sonuç: Cerrahi müdahaleden hemen sonra verilen tek yüksek doz D vitamini enjeksiyonunun, osteoporotik sıçanların kondiler kırıklarında TGFβ ve osteopontin seviyelerini ve yeni kemik oluşumunu arttırdığını tespit ettik.

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Cite This Article

TURER, A., KELAHMETOGLU, O., MERAL, D. G., MERCAN, U., KABAK, Y. B. (2022). The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. 7tepe Klinik, Cilt: 15 - Sayı: 1, 70–76. https://ajindex.com/articles/420103

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