After entrapped method, loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:The aim of controlled insulin delivery study experiments is to produce the smart hydrogel to use insulin release for human body.
📊
Key Findings & Data:Insulin entrapped p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragit L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker and new alternative ways were worked on to find and develop.
💡
Conclusion & Impact:After entrapped method, loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hydrogel · insulin · Taguchi
Abstract
The aim of controlled insulin delivery study experiments is to produce the smart hydrogel to use insulin release for human body. Insulin entrapped p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragit L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker and new alternative ways were worked on to find and develop. Taguchi method was used and optimum synthesis conditions were determined. Insulin was entrapped into hydrogels as synthesis. After entrapped method, loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis.
OZGUNDUZ, H. I., KANDILCI, H. G., ACARALI, N., SARAC, H. (2016). PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE. Sigma Mühendislik ve Fen Bilimleri Dergisi, Cilt: 34 - Sayı: 1, 115–122. https://ajindex.com/articles/419452
Byrne M.E., Park K., Peppas N.A., “Synthesis, Swelling and Drug Release Behavior of Poly(N,N-diethylacrylamide-co-N-hydroxymethyl acrylamide) Hydrogel”, Adv. Drug Deliver. Rev., 54(1), 149, 2002
Zou X., Zhao X., Ye L., et al., “Preparation and Drug Release Behavior of pH-Responsive Bovine Serum Albumin-Loaded Chitosan Microspheres”, J. Ind. Eng. Chem., article in press, DOI: 10.1016/j.jiec.2014.06.012, 2014. [3] de Leede L.G.J., de Boer A.G., Ptirtzgen E., et al., “Rate-Controlled Rectal Drug Delivery in Man with a Hydrogel Preparation”, J. Control. Release, 4, 17, 1986
Zhang Y., Wu X., Meng L., et al., “Thiolated Eudragit Nanoparticles for Oral Insulin Delivery: Preparation, Characterization and in Vivo Evaluation”, Int. J. Pharm., 436, 341, 2012
Huynh D.P., Im G.J., Chae S.Y., et al., “Controlled Release of Insulin from pH/Temperature-Sensitive Injectable Pentablock Copolymer Hydrogel”, J. Control. Release, 137, 20 2009
Chaturvedi K., Ganguly K., Nadagouda M.N., et al., “Polymeric Hydrogels for Oral Insulin Delivery”, J. Control. Release, 165, 129, 2013
Hao S., Wang B., Wang Y., et al., “Preparation of Eudragit L 100-55 Enteric Nanoparticles by a Novel Emulsion Diffusion Method”, Colloid. Surface B, 108, 127, 2013
Gandhi A., Jana S., Sen K.K., “In-vitro Release of Acyclovir Loaded Eudragit RLPO®Nanoparticles for Sustained Drug Delivery”, Int. J. Biol. Macromol., 67, 478, 2014
Sadeghi M., “Synthesis and Swelling Behaviors of Graft Copolymer Based on Chitosan-g-Poly(AA-co-HEMA)”, Int. J. Chem. Eng. App., 1(4), 354, 2010
Emileh A., Vasheghani-Farahani E., Imani M., “Swelling Behavior, Mechanical Properties and Network Parameters of pH- and Temperature Sensitive Hydrogels of Poly((2-dimethyl amino) ethyl methacrylate-co-butyl methacrylate)”, Eur. Polym. J., 43, 1986, 2007
Raghavendra C.M., Vidhya R., Tejraj M.A., “pH-Sensitive Oral Insulin Delivery Systems Using Eudragit Microspheres”, Drug Dev. Ind. Pharm., 37(8), 977–985, 2011
Lowman A.M., Morishita M., Kajita M., et al., “Oral Delivery of Insulin Using pH-Responsive Complexation Gels”, Journal of Pharmaceutical Sciences, 88(9), 933-937, 2000
Kaushik G., Thakur I.S., “Isolation and Characterization of Distillery Spent Wash Color Reducing Bacteria and Process Optimization by Taguchi Approach”, Int. Biodeter. Biodegr., 63, 420, 2009.