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Journals / Sigma Mühendislik ve Fen Bilimleri Dergisi / 2019 / Cilt: 37 - Sayı: 4

ENHANCEMENT OF THE SOLUBILITY OF HERBAL POLYPHENOLIC COMPOUNDS IN THE PRESENCE OF LACTIC ACID BUTYLETHER PEG (200)

Gulcemal YILDIZ
Bahire Filiz SENKAL
Ebru TEKNECI
Pages
1223–1233
Publication Date
2019-12-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Solubility and stability studies were performed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Polyphenolic compounds found in some plants are very important for human health because of their antioxidant and some disease healing properties.
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Key Findings & Data:In this study, a new PEG derivative, lactic acid ester of butylether PEG 200 (PEG-ester) has been synthesized and then it has been interacted with curcumin and morin to improve poor water solubility of these polyphenolic compounds.
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Conclusion & Impact:Solubility and stability studies were performed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Curcumin · morin · emulsion

Abstract

Polyphenolic compounds found in some plants are very important for human health because of their antioxidant and some disease healing properties. However polyphenolic compounds have a disadvantage that their bioavailability is low due to their low solubility in water. In this study, a new PEG derivative, lactic acid ester of butylether PEG 200 (PEG-ester) has been synthesized and then it has been interacted with curcumin and morin to improve poor water solubility of these polyphenolic compounds. PEG ester, was found to be miscible with water and significantly improved the water solubility of curcumin and morin. The characterization of emulsion systems formed with PEG-ester in the presence of curcumin and morin were investigated. The amount of curcumin and morin in emulsion systems was carried out by UV/VIS spectrophotometric measurements. Interactions were characterized by FTIR measurements. Solubility and stability studies were performed.

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Cite This Article

YILDIZ, G., SENKAL, B. F., TEKNECI, E. (2019). ENHANCEMENT OF THE SOLUBILITY OF HERBAL POLYPHENOLIC COMPOUNDS IN THE PRESENCE OF LACTIC ACID BUTYLETHER PEG (200). Sigma Mühendislik ve Fen Bilimleri Dergisi, Cilt: 37 - Sayı: 4, 1223–1233. https://ajindex.com/articles/419119

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References (12)

  1. Handique J.G., Baruah J.B. (2002) Polyphenolic compounds: an overview. React. Funct. Polym. 52, 163–188
  2. Zhang J., Li J., Ju Y., Fu Y., Gong T., Zhang Z. (2015) Mechanism of enhanced oral absorption of morin by phospholipid complex based self-nanoemulsifying drug delivery system. Mol. Pharm. 12, 504-513
  3. Prasad S., Tyagi A.K., Aggarwal B.B. (2014) Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice, Cancer Res. Treat. 46, 2-18
  4. Luthra P.M., Singh R., Chandra R. (2001) Therapeutic uses of Curcuma longa (turmeric) Indian J. Clin. Biochem. 16, 153-160
  5. Tian W.X. (2006) Inhibition of Fatty Acid Synthase by Polyphenols. Curr. Med. Chem. 13, 967–977
  6. Cole G.M., Teter B., Frautschy S.A. (2007) Neuroprotectıve effects of curcumın. In: Aggarwal BB, Surh YJ, Shishodia S (eds) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Advances in Experimental Medicine and Biology, vol 595. Springer, Boston, MA [7] Rao C.V., Rivenson A., Simi B., Reddy B.S. (1995) Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Naturally Occurring Plant Phenolic Compound. Cancer Res. 55, 259-266
  7. Kawamori T., Lubet R., Steele V.E. Kelloff G.J., Kaskey R.B., Rao C.V., Reddy B.S. (1999) Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of Colon Cancer. Cancer Res. 59, 597-601
  8. Cheng A.L., Hsu C.H., Lin J.K. et al (2001) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21, 2895-900
  9. Aggarwal B.B., Kumar A., Bharti A.C. (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 23, 363-398
  10. Kim J., Jeong S.W., Quan H., Jeong C. W., Choi J. I., Bae H. B. (2016) Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK J. Anesth. 30, 100 -108
  11. Menon V.P., Sudheer A.R. (2007) Antıoxidant and anti-inflammatory properties of curcumin. In: Aggarwal B.B., Surh Y.J., Shishodia S. (eds) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Advances in Experimental Medicine and Biology, vol
  12. Springer, Boston, MA [13] Piper J.T., Singhal S.S., Salameh M.S., Torman R.T., Awasthi Y.C., Awasthi S. (1998) Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on