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Journals / Sigma Mühendislik ve Fen Bilimleri Dergisi / 2015 / Cilt: 33 - Sayı: 1

SYNTHESIS OF BROMINATED QUINOLINES

Salih ÖKTEN
Dilek EYİGÜN
Osman ÇAKMAK
Pages
8–15
Publication Date
2015-03-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Improved yields and more shortened reaction times were described for the conversion of 6-BrTHQ and 6,8-diBrTHQ into 6-bromoquinoline and 6,8-dibromoquinoline.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, bromination reactions of 1,2,3,4-tetrahydroquinoline by molecular bromine and aromatization reactions of brominated tetrahydroquinolines were reinvestigated.
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Key Findings & Data:Optimal reaction conditions were established for 6-Bromo-1,2,3,4-tetrahydroquinoline (6-BrTHQ ) and 6,8-dibromo-1,2,3,4-tetrahydroquinoline (6,8-diBrTHQ).
💡
Conclusion & Impact:Improved yields and more shortened reaction times were described for the conversion of 6-BrTHQ and 6,8-diBrTHQ into 6-bromoquinoline and 6,8-dibromoquinoline.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Quinoline · tetrahydroquinoline · bromoquinoline

Abstract

In this study, bromination reactions of 1,2,3,4-tetrahydroquinoline by molecular bromine and aromatization reactions of brominated tetrahydroquinolines were reinvestigated. Optimal reaction conditions were established for 6-Bromo-1,2,3,4-tetrahydroquinoline (6-BrTHQ ) and 6,8-dibromo-1,2,3,4-tetrahydroquinoline (6,8-diBrTHQ). Improved yields and more shortened reaction times were described for the conversion of 6-BrTHQ and 6,8-diBrTHQ into 6-bromoquinoline and 6,8-dibromoquinoline.

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Cite This Article

ÖKTEN, S., EYİGÜN, D., ÇAKMAK, O. (2015). SYNTHESIS OF BROMINATED QUINOLINES. Sigma Mühendislik ve Fen Bilimleri Dergisi, Cilt: 33 - Sayı: 1, 8–15. https://ajindex.com/articles/419045

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References (13)

  1. Kirsch, R., Kleim, J. P., Ries, G., Rosenstock, B., Roesner, M., Winkler, I. DE Patent 19,613,591, (1997)
  2. Srivastava, S. K., Chauhan, P. M. S., Bhaduri, A. P., Fatima, N., Chatterjee, R. J. Med. Chem., 43, 2275, (2000)
  3. Desai, P. K., Desai, P., Machhi, D., Desai, C. M., Patel, D. Indian J. Chem. Sect. B, 35(B), 871, (1996)
  4. Muscia, G. C., Bollini, M., Carnevale, J. P., Bruno, A. M., Asis, S. E. Tetrahedron Lett., 47, 8811, (2006)
  5. Agarwal, A. K., Jenekhe, S. A. Macromolecules, 24, 6806 (1991)
  6. Zhang, X., Shetty, A. S., Jenekhe, S. A. Macromolecules, 32, 7422 (1999)
  7. Zhang, N., Wu, B.,Powell, D., Wissner, A., Floyd, M.B., Kovacs, E.D., Toral-Barza, L., Kohler, C. Bioorg. Med. Chem. Lett., 10, 2825-2828, (2000)
  8. Jenekhe, S. A., Lu, L., Alam, M. M. Macromolecules, 34, 7315. (2001)
  9. Solomon, V. R., Lee, H. Eur. J. Pharmacol., 625, 220, (2009)
  10. Boschelli, D.H., Wang, D.Y., Ye, F., Wu, B., Zhang, N., Dutia, M., Powell D. W., Wissner, A., Arndt, K., Weber, J.M., Boschelli, J. Med. Chem., 44, 822-833, (2001)
  11. Company of a Chemistry Partner of Drug Discovery “BioBloks inc.”, 2002, San Diego, CA, USA. http://www.bioblocks.com/quinolines.html, [Erişim tarihi; 26 Şubat 2014]
  12. Şahin, A., Çakmak, O., Demirtaş, İ., Ökten, S., Tutar, A., Tetrahedron, 64 (43), 10068-10074 (2008)
  13. Ökten, S, Çakmak O, Erenler R, Tekin Ş, Yüce Ö., Turk. J. Chem. 37, 896-908 (2013).