Journals / Turkish Neurosurgery / 2011 / Cilt: 21 - Sayı: 2

Parkinson hastalarında subtalamik çekirdek derin beyin stimülasyonunun fiziksel, emosyonel, kognitif fonksiyon ve günlük yaşam aktiviteleri üzerine etkisi

The influence of subthalamic nucleus deep brain stimulation on physical, emotional, cognitive functions and daily living activities in patients with Parkinson's disease

Pages
140–146
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

RESULTS: The results showed that all the patients' mobility and balance ability improved after surgery (p<0.05).

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: To describe effectiveness of deep brain stimulation of subthalamic nucleus (DBS STN) on physical, emotional, cognitive functions and daily activities in Parkinson's patients.
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Key Findings & Data:MATERIAL and METHODS: Ten patients (51.20 ±10.20 yr.) were assessed three times.
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Conclusion & Impact:RESULTS: The results showed that all the patients' mobility and balance ability improved after surgery (p<0.05).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AIM: To describe effectiveness of deep brain stimulation of subthalamic nucleus (DBS STN) on physical, emotional, cognitive functions and daily activities in Parkinson's patients. MATERIAL and METHODS: Ten patients (51.20 ±10.20 yr.) were assessed three times. The Time Up and Go Test, 12 m Walking Test and Chair Stand Test were used to assess mobility and balance. Purdeu Pegboard and hand writing tests were used to evaluate hand function. The Hospital Anxiety and Depression Scale (HAD) was used to detect depressive symptoms and anxiety score. The Unified Parkinson\'s Disease Rating Scale (UPDRS) and Hoehn &Yahr Scale were also used. The Schwab and England Test was used to evaluate the daily activities (ADL). RESULTS: The results showed that all the patients' mobility and balance ability improved after surgery (p<0.05). Depressive symptoms / anxiety scores were found to be lower than before surgery (p<0.05). There were differences in terms of ADL and UPDRS scores after surgery (p<0.05). At six month after surgery; depressive symptoms decreased by 78%. ADL and UPDRS motor and total scores improved by 190%, 72%, and 78% respectively. CONCLUSION: STN DBS is an effective treatment to improve physical functioning, emotional status and daily activities in Parkinson's patients. However, it did not show any positive effect on cognitive function.

Özet

AMAÇ: Parkinson hastalarında Subtalamik Çekirdek Derin Beyin Stimülasyon’un (STN DBS) fiziksel, emosyonel, kognitif fonksiyon ve günlük yaşam aktiviteleri üzerine etkilerini değerlendirmek. YÖNTEM ve GEREÇ: STN DBS cerrahisi uygulanan 10 hasta cerrahi öncesi, cerrahi sonrası 3. ve 6. ayda değerlendirilmiştir. Mobilite ve denge yeteneği Süreli Kalk Yürü Testi, 12 m Yürüme Testi, Otur-Kalk Testi ile el fonksiyonları Purdue Pegboard Testi ve el ile yazı yazma testleri ile ve emosyonel statü Hastane Anksiyete ve Depresyon Ölçeği (HAD) ile değerlendirilmiştir. Parkinson hastalığının klinik şiddetini belirlemek için Birleşik Parkinson Hastalığı Değerlendirme Ölçeği (BPHDÖ), evreyi belirlemede Hoehn&Yahr Ölçeği, günlük yaşam aktivitelerinin (GYA) değerlendirilmesinde Schwab ve England GYA ölçeği kullanılmıştır. BULGULAR: Olguların yaş ortalaması 51,20 ±10,20 yıldır. Sonuçta mobilite ve denge yeteneği test sonuçlarında cerrahi sonrasında anlamlı gelişmeler elde edilmiştir (p<0.05). Depresyon / anksiyete skorları cerrahi öncesine göre daha düşük bulunmuştur (p<0.05). Cerrahi sonrasında GYA ve BPHDÖ skorları arasında istatistiksel anlamlı farklılık bulunmuştur (p<0.05). Tedavinin etkinliği açısından incelendiğinde cerrahi sonrası 6. ayda depresif semptomlarda %78 azalma, GYA %190, BPHDÖ motor bulgularda %72, BPHDÖ toplam skorda %78 oranında gelişme elde edilmiştir. SONUÇ: STN DBS cerrahisinin parkinson hastalarında fiziksel fonksiyon, emosyonel statü ve GYA üzerine iyileştirici yönde etkileri olduğunu, fakat kognitif fonksiyonlar üzerine etkisi olmadığını göstermiştir.

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Cite This Article

ALTUĞ, F., ACAR, F., ACAR, G., CAVLAK, U. (2011). Parkinson hastalarında subtalamik çekirdek derin beyin stimülasyonunun fiziksel, emosyonel, kognitif fonksiyon ve günlük yaşam aktiviteleri üzerine etkisi. Turkish Neurosurgery, Cilt: 21 - Sayı: 2, 140–146. https://ajindex.com/articles/417762

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References (1)

  1. Altug F, Cavlak U, Buker N, Kitiş A: The effects of physical and nonphysical functioning on one-leg standing balance in population of institutionalized adults. Sport Medicine Journal 16:1013-1019, 2008 2. Capecci M, Ricciuti RA, Burini D, Bombace VG, Provinciali L, Lacoangeli L, Scerrati M, Ceravolo MG: Functional improvement after Subthalamic Stimulation in Parkinson’s disease: A nonequivalent controlled study with 12–24 month follow up. J Neurol Neurosurg Psychiatry 76:769-774, 2005 3. Ford B, Winfield L, Pullman SL: Subthalamic Nucleus Stimulation in advanced Parkinson’s disease: Blinded assessments at one year follow up. J Neurol Neurosurg Psychiatry 75:1255-1259, 2004 4. Funkiewiez A, Ardouin C, Caputo E, Klark P, Fraix V, Klinger H, Chabardes S, Foote K, Benabid AL, Pollak P: Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson’s disease. J Neurol Neurosurg Psychiatry 75: 834-839, 2004 5. Goetz CG, Koller WC, Poewe W, Rascol O, Sampaio C: Management of Parkinson’s disease: An evidence-based review. Mov Disorders 17: 1-166, 2002 6. Guehl D, Dehail P, De Se`ze MP, Cuny E, Faux P, Tison F, Barat M, Bioulac B, Burbaud P: Evolution of postural stability after Subthalamic Nucleus Stimulation in Parkinson’s disease: A combined clinical and posturometric study. Exp Brain Res 170: 206-215, 2006 7. Kelly VE, Israel SM, Samii A, Slimp JC, Goodkin R, Shumway CA: Assessing the effects of Subthalamic Nucleus Stimulation on gait and mobility in people with Parkinson Disease. Disability & Rehabilitation 32(11):929-936, 2010 8. Kleiner-Fisman G, Fisman DN, Sime E, Saint-Cyr JA, Lozano AM, Lang AE: Long-term of bilateral deep brain stimulation of the Subthalamic Nucleus in patients with advanced Parkinson’s disease. J Neurosurg 99: 489–495, 2003 9. Krack P, Batir A, Blercom NV, Chabardes S, Fraix V, Ardouin C, Koudsie A, Limousin PD, Benazzouz A, LeBas JF, Benabid AL, Pollak P: Five-year follow-up of bilateral stimulation of the Subthalamic Nucleus in advanced Parkinson’s disease. N Engl J Med 349(20):925-934, 2003 10. Martínez-Martín P, Valldeoriola F, Tolosa E, Pilleri M, Molinueva JL, Rumia J, Ferrer E: Bilateral Subthalamic Nucleus stimulation and quality of life in advanced Parkinson’s disease. Movement Disorders 17(2):372-377, 2002 11. Montgomery EB, Hallett M, Litvan I, Lozano AM, Goetz C, and Koller WC: Evaluation of surgery for Parkinson’s disease: Report of the therapeutics and technology a