AI Summary & Key Takeaways
AI InsightThe present study found that age at diagnosis, Neurofibromatosis type 1 (NF-1) history, tumor sites,malignant grade, Ki-67 and tumor resection method might be factors closely associated with recurrence and survival of intraspinalMPNSTs patients.CONCLUSION: Benign-appearing intraspinal MPNSTs are relatively rare tumors with a better overall prognosis compared withcommon spinal MPNSTs.
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Özet
AIM: To investigate the clinical characteristics and prognostic factors that may influence outcomes of patients undergoing benignappearing intraspinal malignant peripheral nerve sheath tumors (MPNSTs).MATERIAL and METHODS: This study included a total of 14 consecutive patients who were diagnosed with benign intraspinaltumors firstly and confirmed as intraspinal MPNSTs by pathology. The univariate analyses of various clinical factors were performedto identify variables that could predict prognosis. Endpoints were mortality and local recurrence. The survival rate was estimatedusing the Kaplan–Meier method, and differences were analyzed by carrying out the log-rank test. In addition, factors with p valuesof ≤0.05 were considered statistically significant.RESULTS: Benign-appearing intraspinal MPNSTs showed some different clinical features compared with spinal MPNSTs andintraspinal benign tumors. The present study found that age at diagnosis, Neurofibromatosis type 1 (NF-1) history, tumor sites,malignant grade, Ki-67 and tumor resection method might be factors closely associated with recurrence and survival of intraspinalMPNSTs patients.CONCLUSION: Benign-appearing intraspinal MPNSTs are relatively rare tumors with a better overall prognosis compared withcommon spinal MPNSTs. A lot of factors can affect patients’ survival and local recurrence. These prognostic factors still requirefurther confirmation with further studies including more patients.