Spinal Subarachnoid Hemorrhage Induced Intractable Miotic Pupil. A Reminder of Ciliospinal Sympathetic Center Ischemia Based Miosis: An Experimental Study

There was an inverse relationship between degenerated neuron density of the ciliospinalnuclei and pupil diameters.CONCLUSION: We showed and reported for the first time that ciliospinal sympathetic center ischemia-induced neurodegenerationmay have been responsible for permanent miosis following SAH.

📌 3 Key Takeaways

🎯

Objective & Hypothesis:AIM: To examine ischemic neurodegeneration of the ciliospinal center on permanent miosis following subarachnoid hemorrhage(SAH).MATERIAL and METHODS: Nineteen rabbits were examined in this study.

📊

Key Findings & Data:The animals were divided into three groups, as control(GI, n=5), sham (GII, n=5) and study group (GIII, n=9).

💡

Conclusion & Impact:There was an inverse relationship between degenerated neuron density of the ciliospinalnuclei and pupil diameters.CONCLUSION: We showed and reported for the first time that ciliospinal sympathetic center ischemia-induced neurodegenerationmay have been responsible for permanent miosis following SAH.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Özet

AIM: To examine ischemic neurodegeneration of the ciliospinal center on permanent miosis following subarachnoid hemorrhage(SAH).MATERIAL and METHODS: Nineteen rabbits were examined in this study. The animals were divided into three groups, as control(GI, n=5), sham (GII, n=5) and study group (GIII, n=9). Pupil diameters were measured after giving 0.5 mL physiological saline forsham and autologous arterial blood for the study group into the cervico-thoracic subarachnoid space. After three weeks of followup, the cervico-thoracic cord and bilateral superior cervical sympathetic ganglia were removed. The pupil diameter values werecompared with degenerated neuron volumes of sympathetic ganglia and degenerated neuron densities of thoracic sympatheticnuclei which were studied by stereological methods.RESULTS: The mean pupil diameter was 5180 ± 370 µm and the mean degenerated neuron density of the ciliospinal center was 4± 1/mm3 in animals of the control group (GI). These values were 9850 ± 610 µm, 10 ± 3/mm3 in sham (GII), and 7.010 ± 440 µm and98 ± 21/mm3 in the study (GIII) groups. There was an inverse relationship between degenerated neuron density of the ciliospinalnuclei and pupil diameters.CONCLUSION: We showed and reported for the first time that ciliospinal sympathetic center ischemia-induced neurodegenerationmay have been responsible for permanent miosis following SAH.

🔖

Cite This Article

AYDIN, M. D., KANAT, A., YOLAŞ, C., SOYALP, C., ONEN, M. R., YILMAZ, İ., KARAAVCI, N. C., ÇALIK, M., BAYKAL, O., RAMAZANOGLU, L. (2019). Spinal Subarachnoid Hemorrhage Induced Intractable Miotic Pupil. A Reminder of Ciliospinal Sympathetic Center Ischemia Based Miosis: An Experimental Study. Turkish Neurosurgery, Cilt: 29 - Sayı: 3, 434–439. https://ajindex.com/articles/417657

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (1)

Aydin MD, Kanat A, Yilmaz A, Cakir M, Emet M, Cakir Z, Aslan S, Altas S, Gundogdu C: The role of ischemic neurodegeneration of the nodose ganglia on cardiac arrest after subarachnoid hemorrhage: An experimental study. Exp Neurol 230(1):90-95, 2011 2. Aydin MD, Onder S, Ulvi H, Onder A, Baykal O: Histopathological alterations in ciliary ganglions in meningitis: An experimental study. Minim. Invasive Neurosurg 48:297–301, 2005 3. Aydin MD, Akyol-Salman I, Sahin O: Histopathological changes in ciliary ganglion of rabbits with subarachnoid hemorrhage. Int J Neurosci 115:1595–1602, 2005 4. Aydin N, Kotan D, Keles S, Ondas O, Aydin MD, Baykal O, Gundogdu B: An experimental study of the neurophysical mechanisms of photophobia induced by subarachnoid hemorrhage. Neurosci Lett 630:93–100, 2016 5. Blumen SC, Feiler-Ofry V, Korczyn AD: The pupil cycle time in Horner’s syndrome. J Clin Neuroophthalmol 6:232–235, 1986 6. Bostan H, Cabalar M, Altinay S, Kalkan Y, Tumkaya L, Kanat A, Balik S, Erkut A, Altuner D, Salihoglu Z, Kocer A: A histopathological examination: The sciatic nerve injury following analgesic drug injection in rats. North Clin Istanbul 5:176–185, 2018 7. Cagan E, Sayin R, Dogan M, Peker E, Cagan HH, Caksen H: Bilateral brachial plexus palsy and right Horner syndrome due to congenital cervicothoracal syringomyelia. Brain Dev 32:595–597, 2010 8. Gasenzer ER, Kanat A, Ozdemir V, Neugebauer E: Analyzing of dark past and bright present of neurosurgical history with a picture of musicians. Br J Neurosurg 32(3):303-304,2018 9. Kanat A: Brain oxygenation and energy metabolism: Part 1-Biological function and pathophysiology. Neurosurgery 52: 1508–1509; author reply 1509, 2003 10. Kanat A, Aydin MD: Asymptomatic familial cerebral aneurysms. Neurosurgery 44:1364–1365, 1999 11. Kanat A, Turkmenoglu O, Aydin MD, Yolas C, Aydin N, Gursan N, Tumkaya L, Demir R: Toward changing of the pathophysiologic basis of acute hydrocephalus after subarachnoid hemorrhage: A preliminary experimental study. World Neurosurg 80:390–395, 2013 12. Kanat A, Yilmaz A, Aydin MD, Musluman M, Altas S, Gursan N: Role of degenerated neuron density of dorsal root ganglion on anterior spinal artery vasospasm in subarachnoid hemorrhage: Experimental study. Acta Neurochir (Wien) 152: 2167–2172, 2010 13. Kerrison JB, Biousse V, Newman NJ: Isolated Horner’s syndrome and syringomyelia. J Neurol Neurosurg Psychiatry 69:131–132, 2000 14. Lee JY, Huang DL, Keep R, Sagher O: Effect of electrical stimu