However, thecombination of NAC and DAPT had the highest bactericidal effects of all the groups.CONCLUSION: The resistance of bacteria and the dose-dependent effects of antibiotics can be considered.
📌 3 Key Takeaways
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Objective & Hypothesis:AIM: To examine the effects of N-acetylcysteine (NAC) alone and in combination with linezolid (LIN) and daptomycin (DAPT) onmethicillin-sensitive Staphylococcus aureus (MSSA) biofilm formation.MATERIAL and METHODS: Twelve groups (each containing six molds) of standard ventriculoperitoneal shunts were infected withMSSA.
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Key Findings & Data:The effect of NAC alone and in combination with DAPT andLIN were shown by microbial counts and electron microscopic observation.RESULTS: There was no significant difference in biofilm formation in shunts after different antibiotic treatments.
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Conclusion & Impact:However, thecombination of NAC and DAPT had the highest bactericidal effects of all the groups.CONCLUSION: The resistance of bacteria and the dose-dependent effects of antibiotics can be considered.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
AIM: To examine the effects of N-acetylcysteine (NAC) alone and in combination with linezolid (LIN) and daptomycin (DAPT) onmethicillin-sensitive Staphylococcus aureus (MSSA) biofilm formation.MATERIAL and METHODS: Twelve groups (each containing six molds) of standard ventriculoperitoneal shunts were infected withMSSA. By using microbiological and electron microscopic evaluation methods, NAC was evaluated, alone and in combination withDAPT and LIN, in terms of preventing and eliminating biofilm capacity. The effect of NAC alone and in combination with DAPT andLIN were shown by microbial counts and electron microscopic observation.RESULTS: There was no significant difference in biofilm formation in shunts after different antibiotic treatments. However, thecombination of NAC and DAPT had the highest bactericidal effects of all the groups.CONCLUSION: The resistance of bacteria and the dose-dependent effects of antibiotics can be considered.
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Cite This Article
KURUOĞLU, T., ONGER, M. E., TURAN, D. B., KURUOĞLU, E. (2019). In Vitro Activity of Linezolid, Daptomycin and N-acetylcysteine Agents on Staphylococcus Aureus Biofilms in the Ventriculoperitoneal Shunt Model. Turkish Neurosurgery, Cilt: 29 - Sayı: 1, 66–71. https://ajindex.com/articles/417649
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