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Journals / Organic Communications / 2022 / Cilt: 15 - Sayı: 2

Synthesis and reactivity of novel trityl-type protecting groups

İbrahim DEMİRTAŞ
Mehmet BİRİNCİ
Yakup BUDAK
Ömer ANDAÇ
Oguz ÖZBEK
William T. A. HARRİSON
Pages
108–116
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It can be said that the new protective groups synthesized in this study can be a good alternative to other protecting groups in terms of low solvent use, simple procedures, economic advantages, and environmental protection.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Trityl-type new protecting groups were easily prepared from the reaction of 1 bromonaphthalene or 2- bromonaphthalene and 4-methoxy substituted benzophenones following the Grignard reaction.
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Key Findings & Data:Aryl-methyl alcohols were transferred to tetrafluoroborate salts using tetrafluoroboric acid.
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Conclusion & Impact:It can be said that the new protective groups synthesized in this study can be a good alternative to other protecting groups in terms of low solvent use, simple procedures, economic advantages, and environmental protection.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Trityl-type new protecting groups were easily prepared from the reaction of 1 bromonaphthalene or 2- bromonaphthalene and 4-methoxy substituted benzophenones following the Grignard reaction. Aryl-methyl alcohols were transferred to tetrafluoroborate salts using tetrafluoroboric acid. The alcohols also reacted with acetyl chloride to give halides of the protecting groups. The selective protection of amine, sulfur, and hydroxyl groups was obtained by the reaction of the newly synthesized protecting groups (halides and tetrafluoroborate salts). Slightly aqueous acidic conditions were used for deprotection reactions to give alcohols. It can be said that the new protective groups synthesized in this study can be a good alternative to other protecting groups in terms of low solvent use, simple procedures, economic advantages, and environmental protection.

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Cite This Article

DEMİRTAŞ, İ., BİRİNCİ, M., BUDAK, Y., ANDAÇ, Ö., ÖZBEK, O., HARRİSON, W. T. A. (2022). Synthesis and reactivity of novel trityl-type protecting groups. Organic Communications, Cilt: 15 - Sayı: 2, 108–116. https://ajindex.com/articles/417564

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References (9)

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