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Journals / Sigma Mühendislik ve Fen Bilimleri Dergisi / 2020 / Cilt: 38 - Sayı: 4

ANTI-OXIDATIVE EFFECTS OF GYPSOPHILA PERFOLIATA ON D-GALACTOSE INDUCED AGING IN RAT

Korkut Furkan ŞAHİN
Emel Serdaroğlu KAŞIKÇI
Burcu ÇEVRELİ
Gökhan ZENGİN
Tayfun GÖZLER
Muhsin KONUK
Pages
1657–1664
Publication Date
2021-10-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The data were analyzed by use of the SPSS software package (20th version) One-way ANOVAs followed by post-hoc Bonferroni tests were used, and p

📌 3 Key Takeaways

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Objective & Hypothesis:D-Galactose (D-GAL), a monosaccharide, induces the oxidative stress and results in the mimicked aging model in rats.
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Key Findings & Data:For this, Wistar-albino rats (n=8 in each group of 4) have been applied D-GAL (150 mg/kg/day) subcutaneously (s.c.) and Gypsophila extract (100 mg/kg/day) via gavage for 12 weeks.
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Conclusion & Impact:The data were analyzed by use of the SPSS software package (20th version) One-way ANOVAs followed by post-hoc Bonferroni tests were used, and p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Aging · D-galactose · Gypsophila perfoliata

Abstract

D-Galactose (D-GAL), a monosaccharide, induces the oxidative stress and results in the mimicked aging model in rats. Gypsophila perfoliata belongs to Caryophyllaceae family and a perennial plant. The content of this plant is rich in saponarin and Phenolics, therefore scientist has been focused on its possible antioxidative effects. In this study, we studied the antioxidant effect of Gypsophila perfoliata on aging mimicked rats induced by D-GAL. For this, Wistar-albino rats (n=8 in each group of 4) have been applied D-GAL (150 mg/kg/day) subcutaneously (s.c.) and Gypsophila extract (100 mg/kg/day) via gavage for 12 weeks. After this period, the rats were sacrificed and their blood serum and brains used to determine Glutathione (GSH) and Malondialdehyde (MDA). The data were analyzed by use of the SPSS software package (20th version) One-way ANOVAs followed by post-hoc Bonferroni tests were used, and p

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Cite This Article

ŞAHİN, K. F., KAŞIKÇI, E. S., ÇEVRELİ, B., ZENGİN, G., GÖZLER, T., KONUK, M. (2021). ANTI-OXIDATIVE EFFECTS OF GYPSOPHILA PERFOLIATA ON D-GALACTOSE INDUCED AGING IN RAT. Sigma Mühendislik ve Fen Bilimleri Dergisi, Cilt: 38 - Sayı: 4, 1657–1664. https://ajindex.com/articles/417535

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References (2)

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