Journals / İstanbul Journal of Pharmacy / 2019 / Cilt: 49 - Sayı: 3

Synthesis, characterization, antibacterial and antifungal evaluation of novel cyclohexanone benzoylhydrazones

Pages
142–147
Publication Date
2019-12-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Compounds 2a, 2b, 2e, 2f and 2i further exhibited marginal antifungal activity against Candida parapsilosis

📌 3 Key Takeaways

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Objective & Hypothesis:A novel series of benzoyl hydrazones (2a-j) were synthesized and evaluated, in vitro, for antimicrobial activity against selected bacteria and fungi.
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Key Findings & Data:The structures of the compounds were established by IR, 1 H-NMR, 13C-NMR (APT), electrospray ionization mass spectrometry (ESI-MS) and microanalysis (C, H, N).
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Conclusion & Impact:Compounds 2a, 2b, 2e, 2f and 2i further exhibited marginal antifungal activity against Candida parapsilosis
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hydrazone · cyclohexanone · antibacterial activity

Abstract

A novel series of benzoyl hydrazones (2a-j) were synthesized and evaluated, in vitro, for antimicrobial activity against selected bacteria and fungi. The structures of the compounds were established by IR, 1 H-NMR, 13C-NMR (APT), electrospray ionization mass spectrometry (ESI-MS) and microanalysis (C, H, N). All of the tested compounds, except for compound 2h, displayed weak antibacterial properties against Staphylococcus epidermidis ATCC 12228 and Staphylococcus aureus ATCC 29213. Compounds 2a, 2b, 2e, 2f and 2i further exhibited marginal antifungal activity against Candida parapsilosis

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Cite This Article

CİHAN-ÜSTÜNDAĞ, G., MATARACI-KARA, E., ÇAPAN, G. (2019). Synthesis, characterization, antibacterial and antifungal evaluation of novel cyclohexanone benzoylhydrazones. İstanbul Journal of Pharmacy, Cilt: 49 - Sayı: 3, 142–147. https://ajindex.com/articles/41743

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References (1)

  1.  (2018) WHO-World Health Organization. Antibiotic resistance, https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance. Accessed 05.04.2019.  Backes GL, Neumann DM, Jursic BS (2014) Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides. Bioorg Med Chem 22: 4629-36.  Clinical Laboratory Standards Institute (CLSI) document (1997) Approved standard-2nd edition M27-A2. Clinical and Laboratory Standards Institute. Wayne, PA, USA.  Clinical Laboratory Standards Institute (CLSI) document (2006). Approved standard-7th edition M7-A7. Clinical and Laboratory Standards Institute. Wayne, PA, USA.  Ge YQ, Li FR, Zhang YJ, Bi YS, Cao XQ, Duan GY, Wang JW, Liu ZL (2014) Synthesis, crystal structure, optical properties and antibacterial evaluation of novel imidazo[1,5‐a]pyridine derivatives bearing a hydrazone moiety. Luminescence 29: 293-300.  Gürkök G, Altanlar N, Süzen S (2009) Investigation of antimicrobial activities of indole-3-aldehyde hydrazide/hydrazone derivatives. Chemotherapy 55: 15-19.  Kaplancıklı ZA, Yurttas L, Turan-Zitouni G, Özdemir A, Göğer G, Demirci F, Mohsen UA (2014) Synthesis and antimicrobial activity of new pyrimidine-hydrazones. Lett Drug Des Discov 11: 76-81.  Kumar D, Judge V, Narang R, Sangwan S, De Clercq E, Balzarini J, Narasimhan B (2010) Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation. Eur J Med Chem 45: 2806-2816.  Laxminarayan R, Sridhar D, Blaser M, Wang M, Woolhouse M (2016) Achieving global targets for antimicrobial resistance. Science 353: 874-875.  Luepke KH, Suda KJ, Boucher H, Russo RL, Bonney MW, Hunt TD, Mohr (2017) Past, present, and future of antibacterial economics: Increasing bacterial resistance, limited antibiotic pipeline and societal implications. Pharmacotherapy 37: 71-84.  Moldovan C, Oniga O, Meda R, Tiperciuc B, Verite P, Pirnau A, Crisan O, Bojita M (2011) Synthesis and antimicrobial screening of novel 2, 3 or 4-[2-aryl-thiazol-ylmethoxy (oxo-ethoxy)]-benzaldehyde isonicotinoyl hydrazone analogs. Farmacia 59: 659-668.  Morjan RY, Mkadmh AM, Beadham I, Elmanama AA, Mattar MR, Raftery J, Pritchard RG, Awadallah AM, Gardiner JM (2014) Antibacterial activities of novel nicotinic acid hydrazides and their conversion into N-acetyl-1,3,4-oxadiazoles. Bioorg Med Chem Lett 24: 5796-5800.  Nastasa C, Tiperciuc B, Duma M, Benedec D, Oniga O (2015) New hydrazones bearing thiazole