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Journals / İstanbul Journal of Pharmacy / 2020 / Cilt: 50 - Sayı: 1

Determination of sultamicillin in bulk and pharmaceutical preparations via derivatization with NBD-Cl by spectrophotometry

Elif ÖZDEMİR
Duygu TAŞKIN
Sıdıka SUNGUR
Pages
1–5
Publication Date
2020-04-01
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The suggested method was validated, and can be applied for routine sultamicillin analysis in dosage formsfor industrial analysis.

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Aims: A new sensitive and selective method for the determination of sultamicillin in bulk and pharmaceutical preparations has been developed.
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Key Findings & Data:Methods: The developed method is based on the derivatization of sultamicillin with 4-chloro-7-nitrobenzofurazan in pH 9.0 borate buffer at 70ºC for 60 min.
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Conclusion & Impact:Conclusion: The suggested method was validated, and can be applied for routine sultamicillin analysis in dosage formsfor industrial analysis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:4-chloro-7-nitrobenzofurazan · sultamicillin · spectrophotometry

Abstract

Background and Aims: A new sensitive and selective method for the determination of sultamicillin in bulk and pharmaceutical preparations has been developed. Methods: The developed method is based on the derivatization of sultamicillin with 4-chloro-7-nitrobenzofurazan in pH 9.0 borate buffer at 70ºC for 60 min. The derivative was measured spectrophotometrically at 432 nm after extraction with chloroform. Results: The method was validated by linearity, LOD, LOQ, accuracy, precision and recovery parameters. The linear range for sultamicillin was 10-50 µg.mL-1 with a correlation coefficient of 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 1.47 and 4.41 µg/mL-1, respectively. Conclusion: The suggested method was validated, and can be applied for routine sultamicillin analysis in dosage formsfor industrial analysis.

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Cite This Article

ÖZDEMİR, E., TAŞKIN, D., SUNGUR, S. (2020). Determination of sultamicillin in bulk and pharmaceutical preparations via derivatization with NBD-Cl by spectrophotometry. İstanbul Journal of Pharmacy, Cilt: 50 - Sayı: 1, 1–5. https://ajindex.com/articles/41728

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References (1)

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