Journals / Türk Hematoloji Onkoloji Dergisi / 2003 / Cilt: 13 - Sayı: 4

The clinical prognostic of unresectable lung adenocarcinoma

Rezeke edilemeyen akciğer adenokarsinomlarında klinik seyir

Pages
212–217
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Median overall survival was 8 months, 1 and 2 years survival rate were 24% and 12% respectively.

📌 3 Key Takeaways

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Objective & Hypothesis:Lung adenocarcinoma has different epidemiologic and clinical characteristics compared to other nonsmall cell lung cancers.
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Key Findings & Data:In our study, unresectable 27 lung adenocarcinoma and 80 other nonsmall cell lung cancer patients diagnosed during same period were compared according to clinical behavior.
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Conclusion & Impact:Median overall survival was 8 months, 1 and 2 years survival rate were 24% and 12% respectively.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Sağkalım · Karsinom · küçük hücreli dışı akciğer

Abstract

Lung adenocarcinoma has different epidemiologic and clinical characteristics compared to other nonsmall cell lung cancers. In our study, unresectable 27 lung adenocarcinoma and 80 other nonsmall cell lung cancer patients diagnosed during same period were compared according to clinical behavior. Rate of female and stage IV patients were significantly higher at lung adenocarcinoma group (respectively, p=0.007 and p=0.03). 52% of the adenocarcinoma patients had involvement of mediastinal lymph node and 77% peripherally localized mass. Median progression free survival was 6 months, 1 year progression free survival rate 13% in adenocarcinoma patients. Median overall survival was 8 months, 1 and 2 years survival rate were 24% and 12% respectively. Survival was shorter than other group but this was not statistically significant (respectively, p=0.6 and p=0.14). In conclusion, lung adenocarcinoma is a tumor frequently seen in women, generally peripherally located and potential for distant and mediastinal lymph node metastases is high and has a poor prognosis.

Özet

Akciğer adenokarsinomu epidemiyolojik ve klinik seyir açısından diğer küçük hücreli dışı akciğer kanserlerinden farklı özellikler gösteren bir tümördür. Çalışmamızda aynı tarihler arasında rezeke edilemeyen akciğer adenokarsinom tanısı alan 27 hasta ile diğer histolojik alt tiplerde 80 hasta klinik seyir açısından karşılaştırıldı. Akciğer adenokarsinomu tanısı alan kadın hasta ve evre IV hasta oranı diğer gruba göre istatistiksel olarak anlamlı şekilde daha fazla idi (sırasıyla p=0.007 ve p=0.03). Adenokarsinom hastalarının %52' sinde mediastinal lenf nodu tutulumu ve %77' sinde periferik yerleşimli kitle vardı. Adenokarsinom hastalarında ortanca progresyonsuz yaşam süresi 6 ay, bir yıllık progresyonsuz sağkalım %13 idi. Ortanca genel yaşam süresi 8 ay, bir yıllık genel sağkalım %24, iki yıllık genel sağkalım %12 iken, diğer gruba göre sağkalım süreleri daha kısa idi. Fakat aralarında istatistiksel olarak anlamlı fark yoktu (Sırasıyla p=0.6 ve p=0.14). Sonuç olarak akciğer adenokarsinomu kadınlarda sık görülür, genellikle periferik yerleşimli, uzak organ ve mediastinal lenf nodu metastaz potasiyeli daha yüksek ve prognozu daha kötüdür.

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Cite This Article

ÖZKAN, M., ER, Ö., KAPLAN, B., ALTINBAŞ, M., COŞKUN, H. Ş., ALTUNTAŞ, F., ESER, B., KARAHACIOĞLU, E. (2003). The clinical prognostic of unresectable lung adenocarcinoma. Türk Hematoloji Onkoloji Dergisi, Cilt: 13 - Sayı: 4, 212–217. https://ajindex.com/articles/417081

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