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Journals / International Journal of Medical Biochemistry / 2021 / Cilt: 4 - Sayı: 3

Evaluation of vitamin D and calcium mineral metabolism in patients with chronic urticaria

Saadet ÇELİK
Selami Aykut TEMİZ
Turan AKDAĞ
Ali ÜNLÜ
Pages
157–160
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The study findings indicated that the Ca and vitamin D levels in patients with CU were statistically signifi cantly lower than those of the control group.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Chronic urticaria (CU) is a skin disease characterized by the spontaneous occurrence of itchy, swollen welts lasting 6 weeks or more.
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Key Findings & Data:Methods: Patients over the age of 18 who presented at a dermatology outpatient clinic between November 2020 and February 2021 and diagnosed with CU were included in the study.
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Conclusion & Impact:Conclusion: The study findings indicated that the Ca and vitamin D levels in patients with CU were statistically signifi cantly lower than those of the control group.
🔬Design:Research Article
📍Scope:2020 Verileri
⚙️Variables:Domain Parameters

Özet

Objectives: Chronic urticaria (CU) is a skin disease characterized by the spontaneous occurrence of itchy, swollen welts lasting 6 weeks or more. The aim of this study was to assess the potential influence of vitamin D and calcium mineral metabolism in patients with CU. Methods: Patients over the age of 18 who presented at a dermatology outpatient clinic between November 2020 and February 2021 and diagnosed with CU were included in the study. Volunteers with no disease were selected as a control group. The level of 25-hydroxy vitamin D and calcium metabolism parameters (calcium [Ca], phosphorus [P], parathy roid [PTH] hormone) were measured in both groups and compared. Results: The mean age of the participants was 35.01±11.96 years in the urticaria group and 34.89±11.75 years in the control group (p>0.05). The mean serum Ca level was 9.14±0.75 mg/dL in the urticaria group and 9.46±0.43 mg/dL in the control group (p=0.003). The mean serum P level was 3.3±0.71 mg/dL in the urticaria group and 3.3±0.56 mg/ dL in the control group (p=0.76). The mean serum level of PTH was 46.28±16.29 pg/mL in the urticaria group and 41.95±14.09 pg/mL in the control group (p=0.091). The mean serum level of vitamin D in the CU and the control group was as 13.8±5.67 ng/mL and 18.12±8.42 ng/mL, respectively (p<0.001). The 7-day Urticaria Activity Score (UAS7) was 19.99±8.61 in the patients with urticaria. There was a negative correlation between the UAS7 score and the vitamin D level (p=0.001). The mean duration of disease was 20±15.22 months. No correlation was seen between disease duration and the vitamin D level (p=0.49). Conclusion: The study findings indicated that the Ca and vitamin D levels in patients with CU were statistically signifi cantly lower than those of the control group. However, additional studies are needed to further explore the possible contribution of this analysis to the diagnosis and treatment of urticaria.

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Cite This Article

ÇELİK, S., TEMİZ, S. A., AKDAĞ, T., ÜNLÜ, A. (2021). Evaluation of vitamin D and calcium mineral metabolism in patients with chronic urticaria. International Journal of Medical Biochemistry, Cilt: 4 - Sayı: 3, 157–160. https://ajindex.com/articles/413643

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References (18)

  1. Ataseven A, Durmaz K, Temiz SA, Dursun R. Clinical and laboratory assessment for the inflammation role in chronic spontaneous urticaria: A clinical study. Dermatol Ther 2020;33(1):e14125
  2. Amar SM, Dreskin SC. Urticaria. Prim Care 2008;35(1):141–57
  3. Sachdeva S, Gupta V, Amin SS, Tahseen M. Chronic urticaria. Indian J Dermatol 2011;56(6):622–8
  4. Fonacier LS, Dreskin SC, Leung DY. Allergic skin diseases. J Allergy Clin Immunol 2010;125(2):138–49
  5. Kanani A, Schellenberg R, Warrington R. Urticaria and angioedema. Allergy Asthma Clin Immunol 2011;7(1):S9
  6. Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008;88(2):491S-9S
  7. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004;80(6):1689S–96S
  8. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s Principles of Internal Medicine. 19th Ed. New York: McGraw Hill Education Medical; 2015
  9. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357(3):266– 81
  10. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc 2010;85(8):752–7
  11. Wang H, Chen W, Li D, Yin X, Zhang X, Olsen N, et al. Vitamin D and chronic diseases. Aging Dis 2017;8(3):346–53
  12. Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, et al. British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy 2007;37(5):631– 50
  13. Greaves MW. Chronic urticaria. N Engl J Med 1995;332(26):1767– 72
  14. Cantorna MT, Mahon BD. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med 2004;229:1136–42. 15. van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 2005;97:93–101
  15. Tsai TY, Huang YC. Vitamin D deficiency in patients with chronic and acute urticaria: A systematic review and meta-analysis. J Am Acad Dermatol 2018;79(3):573–5
  16. Wang X, Li X, Shen Y, Wang X. The association between serum vitamin D levels and urticaria: a meta-analysis of observational studies. G Ital Dermatol Venereol 2018;153(3):389–95
  17. Rather S, Keen A, Sajad P. Serum Levels of 25-hydroxyvitamin D in Chronic Urticaria and its Association with Disease Activity: A Case Control Study. Indian Dermatol Online J 2018;9(3):170–4
  18. Woo YR, Jung