Our patient is still well and able to work actively 4 years after diagnosis with the treatment of 12 courses of VAD by reducing the vincristine dosage.
📌 3 Key Takeaways
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Objective & Hypothesis:POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) is a rare disease and constitues 1-2% of plasma cell dyscrasia.
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Key Findings & Data:Most of the patients have few sclerotic bone lesions and more than 90% of patients have serum and/or urinary M-protein.
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Conclusion & Impact:Our patient is still well and able to work actively 4 years after diagnosis with the treatment of 12 courses of VAD by reducing the vincristine dosage.
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) is a rare disease and constitues 1-2% of plasma cell dyscrasia. Most of the patients have few sclerotic bone lesions and more than 90% of patients have serum and/or urinary M-protein. In this report, we present a patient with POEMS syndrome who had severe polyneuropathy and unusual widespread osteosclerotic lesions without M-protein in serum and urine. According to our knowledge, this is the first case of asecretory POEMS syndrome with multipl sclerotic lesions and polyneuropathy. Our patient is still well and able to work actively 4 years after diagnosis with the treatment of 12 courses of VAD by reducing the vincristine dosage.
TOMBULOĞLU, M., SAYDAM, G., DÖNMEZ, A., ÇAĞIRGAN, S., HEKİMGİL, M., SOYDAN, S., ŞENCAN, M., BÜYÜKKEÇECİ, F. (2000). Asecretory POEMS syndrome with widespread osteosclerotic lesions. Turkish Journal of Hematology, Cilt: 17 - Sayı: 2, 81–84. https://ajindex.com/articles/413453