Journals / Turkish Journal of Hematology / 2009 / Cilt: 26 - Sayı: 1

Akut lenfoblastik lösemili adolesan bir kız çocukta her iki diz ve sağ topukta osteonekroz

Bilateral knee and right ankle osteonecrosis in an adolescent girl with acute lymphoblastic leukemia

Pages
34–37
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Early recognition of this condition is important in prevention of disabling sequela in skeletal system.

📌 3 Key Takeaways

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Objective & Hypothesis:Although rare, avascular necrosis of bone is a serious and incapacitating complication seen in children with acute lymphoblastic leukemia receiving high dose steroids.
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Key Findings & Data:Here we present a 16 year-old girl who developed bilateral knee and right ankle avascular osteonecrosis one year after intensive chemotherapy for medium risk acute lymphoblastic leukemia.
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Conclusion & Impact:Early recognition of this condition is important in prevention of disabling sequela in skeletal system.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Ergen · Kadın · Öncül hücre lenfoblastik lösemi-lenfoma

Abstract

Although rare, avascular necrosis of bone is a serious and incapacitating complication seen in children with acute lymphoblastic leukemia receiving high dose steroids. Here we present a 16 year-old girl who developed bilateral knee and right ankle avascular osteonecrosis one year after intensive chemotherapy for medium risk acute lymphoblastic leukemia. Indirect curettage of necrotic tissue and bone grafting were performed for both knees whereas conservative measures had been sufficient for the ankle. Early recognition of this condition is important in prevention of disabling sequela in skeletal system.

Özet

Yüksek doz steroid tedavisi alan akut lenfoblastik lösemili çocuklarda avasküler kemik nekrozu ender ancak ciddi ve sakatlık bırakan bir komplikasyondur. Orta risk akut lenfoblastik lösemi için yoğun kemoterapi alan ve her iki diz ve sağ topukta avasküler osteonekroz gelişen 16 yaşında bir kız hasta sunulmuştur. Her iki diz nekrotik dokunun küretajı ve kemik grefti ile tedavi edilirken, topukta konservatif tedavi yeterli olmuştur. İskelet sisteminde sekel bırakabilen bu durumun erken tanınması önemlidir.

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Cite This Article

KOÇAK, Ü., KAYA, Z., ALBAYRAK, M., ŞENKÖYLÜ, A., AKYÜREK, N., GÜRSEL, T. (2009). Akut lenfoblastik lösemili adolesan bir kız çocukta her iki diz ve sağ topukta osteonekroz. Turkish Journal of Hematology, Cilt: 26 - Sayı: 1, 34–37. https://ajindex.com/articles/413417

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References (12)

  1. Hanif I, Mahmoud H, Pui CH. Avascular femoral head necrosis in pediatric cancer patients. Med Pediatr Oncol 1993; 21:655 - 60
  2. Geetha N, Kumary PK, Ramachandran K, Nair MK. Avascular necrosis of the femoral head in neuroblastoma: a case report. Pediatr Hematol Oncol 1998; 15: 443-6
  3. Burger B, Beier R, Zimmermann M, Beck JD, Reiter A, Schrappe M. Osteonecrosis: a treatment related toxicity in childhood acute lymphoblastic leukemia (ALL)-experiences from trial ALL-BFM 95. Pediatr Blood Cancer 2005; 44: 220-5
  4. Bomelburg T, von Lengerke HJ, Ritter J. Aseptic osteonecroses in the treatment of childhood acute leukaemias. Eur J Pediatr 1989; 149: 20-3
  5. Bernbeck B, Mauz-Korholz C, Zotz RB, Gobel U. Methylenetetrahydrofolate reductase gene polymorphism and glucocorticoid intake in children with ALL and aseptic osteonecrosis. Klin Padiatr 2003; 215: 327-31
  6. Arico M, Boccalatte MF, Silvestri D, Barisone E, Messina C, Chiesa R, Santoro N, Tamaro P, Lippi A, Gallisai D, Basso G, De Rossi G; Associazione Italiana di Ematologia ed Oncologia Pediatrica. Osteonecrosis: An emerging complication of intensive chemotherapy for childhood acute lymphoblastic leukemia. Haematologica 2003; 88: 747-53
  7. Mattano LA Jr, Sather HN, Trigg ME, Nachman JB. Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: A report from the Children's Cancer Group. J Clin Oncol 2000; 18: 3262-72
  8. Hogler W, Wehl G, van Staa T, Meister B, Klein-Franke A, Kropshofer G. Incidence of skeletal complications during treatment of childhood acute lymphoblastic leukemia: comparison of fracture risk with the General Practice Research Database. Pediatr Blood Cancer 2007; 48: 21-7
  9. Sala A, Mattano LA, Barr RD. Osteonecrosis in children an adolescents with cancer- An adverse effect of systemic therapy. Eur J Cancer 2007; 43: 683 89
  10. Ribeiro RC, Fletcher BD, Kennedy W, Harrison PL, Neel MD, Kaste SC, Sandlund JT, Rubnitz JE, Razzouk BI, Relling MV, Pui CH. Magnetic resonance imaging detection of avascular necrosis of the bone in children receiving intensive prednisone therapy for acute lymphoblastic leukemia or non-Hodgkin lymphoma. Leukemia 2001; 15: 891-7
  11. Kan JH, Hernanz-Schulman M, Frangoul HA, Connolly SA. MRI diagnosis of bone marrow relapse in children with ALL. Pediatr Radiol. 2008; 38: 76-81
  12. Strauss AJ, Su JT, Dalton VM, Gelber RD, Sallan SE, Silverman LB. Bony morbidity in children treated for acute lymphoblastic leukemia. J Clin Oncol 2