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Journals / Turkish Journal of Hematology / 2013 / Cilt: 30 - Sayı: 4

Erişkinlerde haploidentik kök hücre naklinde stratejiler

Strategies in haploidentical stem cell transplantation in adults

D. Ulaş BAYRAKTAR
O. Stefan CIUREA
Pages
342–350
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, we answer the following questions: 1) What are the current transplant strategies used to overcome the histoincompatibility barrier in haploidentical stem cell transplantation and their clinical results? 2) How should we choose the donor when there is more than one available haploidentical donor? 3) How does transplantation from haploidentical donors compare to that from umbilical cord blood?

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Haploidentical related donors are alternative stem cell sources for patients without human leukocyte antigen (HLA)-matched related or unrelated donors.
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Key Findings & Data:Immediate access to the donor, availability for patients with rare haplotypes, ease of stem cell procurement, and lack of a requirement for a physical cord blood bank or an extensive HLA database render this type of hematopoietic stem cell transplantation particularly attractive despite the high histoincompatibility barrier between the recipient and the haploidentical graft.
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Conclusion & Impact:In this review, we answer the following questions: 1) What are the current transplant strategies used to overcome the histoincompatibility barrier in haploidentical stem cell transplantation and their clinical results? 2) How should we choose the donor when there is more than one available haploidentical donor? 3) How does transplantation from haploidentical donors compare to that from umbilical cord blood?
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Haploidentical related donors are alternative stem cell sources for patients without human leukocyte antigen (HLA)-matched related or unrelated donors. Immediate access to the donor, availability for patients with rare haplotypes, ease of stem cell procurement, and lack of a requirement for a physical cord blood bank or an extensive HLA database render this type of hematopoietic stem cell transplantation particularly attractive despite the high histoincompatibility barrier between the recipient and the haploidentical graft. In this review, we answer the following questions: 1) What are the current transplant strategies used to overcome the histoincompatibility barrier in haploidentical stem cell transplantation and their clinical results? 2) How should we choose the donor when there is more than one available haploidentical donor? 3) How does transplantation from haploidentical donors compare to that from umbilical cord blood?

Özet

Tam “human leukocyte antigen” (HLA) uyumlu bağışçı bulunamayan hastalar için bir diğer seçenek yarı-eşlenik akraba bağışçılardan alınacak kök hücrelerdir. Bağışçı ve hasta arasında aşılması gereken yüksek HLA uyumsuzluğuna ragmen, yarı- eşlenik akraba bağışçılarından kan kök hücre nakli (yarı-eşlenik kan kök hücre nakli [YKHN]); bağışçıya anında ulaşılabilirlik, ender gorülen haplotipler icin uygulanabilirlik, kök hücrelerin elde edilmesindeki kolaylık ve kord kanı bankası/doku bankasından bağımsızlığı dolayısıyla cazip bir yontemdir. Bu derlemede şu soruları cevaplandıracağız: 1) YKHN’de HLA uyumsuzluk bariyerini aşmak için kullanılan stratejiler ve sonuçları nelerdir? 2) Birden fazla yarı-eşlenik akraba bağışçısının olması durumunda bağışçı nasıl seçilmelidir? 3) YKHN’in korddan kök hücre nakline göre avantaj ve dezavantajları nelerdir?

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Cite This Article

BAYRAKTAR, D. U., CIUREA, O. S. (2013). Erişkinlerde haploidentik kök hücre naklinde stratejiler. Turkish Journal of Hematology, Cilt: 30 - Sayı: 4, 342–350. https://ajindex.com/articles/413306

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