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Journals / Turkish Journal of Hematology / 2008 / Cilt: 25 - Sayı: 4

Beta talasemi minörde nitrik oksit seviyeleri

The levels of nitric oxide in beta-thalassemia minor

Nihayet BAYRAKTAR
MEHMET ALİ ERKURT
İSMET AYDOĞDU
Yalçın BAŞARAN
Pages
187–189
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This may be helpful in assessing the prognosis and follow-up evaluation of patients with beta-thalassemia minor.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate the relationship between NO (nitric oxide) and beta-thalassemia minor.
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Key Findings & Data:Material and Methods: A total of 60 patients with beta-thalassemia minor (30 M, 30 F) were included in the study.
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Conclusion & Impact:This may be helpful in assessing the prognosis and follow-up evaluation of patients with beta-thalassemia minor.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hemoglobinler · Nitrik oksit · Hemoliz

Abstract

Objective: The aim of this study was to investigate the relationship between NO (nitric oxide) and beta-thalassemia minor. Material and Methods: A total of 60 patients with beta-thalassemia minor (30 M, 30 F) were included in the study. The control group consisted of 60 healthy subjects (30 M, 30 F). Plasma nitrite/nitrate levels were measured using the Griess reaction method and analyzed by spectrophotometry at 545 nm. Results: Plasma direct nitrite, total nitrite and nitrate levels were 7.561±6.19, 42.548±7.37 and 34.84±6.24 in beta-thalassemia minor patients versus 36.9±19.8, 85.9±35.3 and 48.61±17.35 Ìmol/dl in controls, respectively. Plasma direct nitrite, total nitrite and nitrate levels were significantly lower in beta-thalassemia minor patients compared with the control group (p<0.001). Conclusion: These findings confirm that plasma NO levels in beta-thalassemia minor patients are decreased at the time of diagnosis. This may be helpful in assessing the prognosis and follow-up evaluation of patients with beta-thalassemia minor.

Özet

Amaç: Bu çalışmada beta talasemi minor ve nitrik oksit arasındaki ilişki araştırıldı. Yöntem ve Gereçler: Çalışmaya 30 erkek ve 30 kadın olmak üzere toplam 60 beta talasemi minörlü hasta alındı. Kontrol grubu da tamamen sağlıklı 30 erkek ve 30 kadın toplam 60 denekten oluşturuldu. Plazma nitrit/nitrat seviyeleri Griess reaksiyon metodu kullanılarak ölçüldü ve 545 nanometrede spektrometri ile analiz edildi. Bulgular: Beta talasemi hastalarındaki ortalama plazma direk nitrit seviyesi Ìmol/dl olarak 7.56±6.19, total nitrit 42.54±7.37 ve nitrat 34.84 ± 6.24 bulundu. Buna karşılık kontrol grubunda sırasıyla 36.96±19.83, 85.97±35.28 ve 48.61±17.35 bulundu. Beta talasemi minörlü hastalarda plazma direk nitrit, total nitrit ve nitrat seviyesi kontrol grubuna göre istatistiksel olarak anlamlı derecede azaldığı tespit edildi (p<0.001). Sonuç: Bu çalışma tanı anında plazma nitrik oksit seviyelerinin beta talasemi minörlü hastalarda azaldığını göstermektedir. Bu bilgi beta talasemi minörlü hastaların takibinde faydalı olabilir

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Cite This Article

BAYRAKTAR, N., ERKURT, M. A., AYDOĞDU, İ., BAŞARAN, Y. (2008). Beta talasemi minörde nitrik oksit seviyeleri. Turkish Journal of Hematology, Cilt: 25 - Sayı: 4, 187–189. https://ajindex.com/articles/413208

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References (12)

  1. Riou J, Godart C, Mathis M, Hurtrel D, Wajcman H, Préhu C, Bardakdjian J. Evaluation of the Bio-Rad VARIANT II HbA2/HbA1C Dual Program for measurement of hemoglobin concentrations and detection of variants. Clin Chem Lab Med 2005;43:237-43
  2. Engelborghs S, Pickut BA, De Deyn PP. Recurrent transient ischemic attacks in a 15-year-old boy with beta-thalassemia minor and thrombophilia. Contribution of perfusion SPECT to clinical diagnosis. Acta Neurol Belg 2003;103:99-102
  3. Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med 2005;353:1135 46
  4. Mayer B, Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 1997;22:477-81
  5. Domachowske JB, Rafferty SP, Singhania N, Mardiney M 3rd, Malech HL. Nitric oxide alters the expression of gamma-globin, H-ferritin and transferrin receptor in human K562 cells at the posttranscriptional level. Blood 1996;15:2980-8
  6. Reddy PL, Bowie LJ, Callistein S. Binding of nitric oxide to thiols and hemes in hemoglobin H: implications for alpha-thalassemia and hypertension. Clin Chem 1997;43:1442-7
  7. Punnonen K, Irjala K, Rajamaki A. Iron-deficiency anemia with high concentrations of transferrin receptor in serum. Clin Chem 1994;40:774-6
  8. Vichinsky EP. Pulmonary hypertension in sickle cell disease. N Engl J Med 2004;350:857-9
  9. Aessopos A, Kati M, Farmakis D. Heart disease in thalassemia intermedia: a review of the underlying pathophysiology. Haematologica 2007;92:658-65
  10. Aslan M, Freeman BA. Redox-dependent impairment of vascular function in sickle cell disease. Free Radic Biol Med 2007;1:1469-83
  11. Kato GJ, Onyekwere OC, Gladwin MT. Pulmonary hypertension in sickle cell disease: relevance to children. Pediatr Hematol Oncol 2007;24:159-70
  12. Morris CR, Kuypers FA, Kato GJ, Lavrisha L, Larkin S, Singer T, Vichinsky EP. Hemolysis-associated pulmonary hypertension in thalassemia Ann NY Acad Sci 2005;1054:481-5.