Hematopoetik kök hücre transplantasyonunda terapotik aferez

In this review, we address recent developments in therapeutic apheresis for patients undergoing allogeneic HSCT for prevention or treatment of hemolysis in minor ABO-incompatible transplantation, treatment of PRCA after major ABO-incompatible transplantation, and treatment of TAM and GVHD.

📌 3 Key Takeaways

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Objective & Hypothesis:With the introduction of hematopoietic stem cell transplant (HSCT), transplant-associated problems like graft-versus-host disease (GVHD) and transplant-associated microangiopathy (TAM) have occurred.

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Key Findings & Data:In addition, approximately 40% of allogeneic HSCTs are performed across the ABO blood group barrier, bearing the risk for immunohematological complications like severe hemolysis and pure red cell aplasia (PRCA).

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Conclusion & Impact:In this review, we address recent developments in therapeutic apheresis for patients undergoing allogeneic HSCT for prevention or treatment of hemolysis in minor ABO-incompatible transplantation, treatment of PRCA after major ABO-incompatible transplantation, and treatment of TAM and GVHD.

🔬Design:Review & Systematic Survey

📍Scope:Comprehensive Sample

⚙️Variables:Graft vs Host hastalığı · Eritrosit aplazisi · saf

Abstract

With the introduction of hematopoietic stem cell transplant (HSCT), transplant-associated problems like graft-versus-host disease (GVHD) and transplant-associated microangiopathy (TAM) have occurred. In addition, approximately 40% of allogeneic HSCTs are performed across the ABO blood group barrier, bearing the risk for immunohematological complications like severe hemolysis and pure red cell aplasia (PRCA). All these problems can potentially require therapeutic apheresis. In this review, we address recent developments in therapeutic apheresis for patients undergoing allogeneic HSCT for prevention or treatment of hemolysis in minor ABO-incompatible transplantation, treatment of PRCA after major ABO-incompatible transplantation, and treatment of TAM and GVHD.

Özet

Hematopoetik kök hücre transplantasyonunun uygulanmasıyla Graft-versus-host hastalığı (GVHH) gibi transplanta bağlı problemler ve transplanta bağlı mikroanjiyopati (TAM) ortaya çıkmıştır. Ayrıca, allojenik HSCT’lerin yaklaşık %40’ı , şiddetli hemoliz ve saf kırmızı hücre aplazisi (PRCA) gibi immünohematolojik komplikasyon riski taşıyan ABO kan grubu karşın gerçekleştirilmiştir. Tüm bu problemler potansiyel olarak terapötik aferez gerektirebilir. Minör ABO uyumsuz transplantasyonda hemolizin tedavisi veya önlenmesi, majör ABO uyumsuz transplantasyon sonrası PRCA tedavisi ve TAM ve GVHH tedavisi için allojeneik HKHT uygulanan hastalara yönelik terapötik aferez ile ilgili en son gelişmeler bu değerlendirmede ele alınmaktadır

Keywords

Graft vs Host hastalığı Eritrosit aplazisi saf Kan bileşenlerinin çıkarılması Hemoliz Hematopoetik kök hücre nakli Trombotik mikroanjiyopati Graft vs Host Disease Red-Cell Aplasia Pure Blood Component Removal Hemolysis Hematopoietic Stem Cell Transplantation Thrombotic Microangiopathies

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Cite This Article

WOREL, N., LEITNER, G., WAGNER, A., GREINIX, H. T., HOCKER, P., KALHS, P. (2008). Hematopoetik kök hücre transplantasyonunda terapotik aferez. Turkish Journal of Hematology, Cilt: 25 - Sayı: 4, 164–171. https://ajindex.com/articles/413205

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