Poor Prognosis in Acute Myeloid Leukemia Patients with Monosomal Karyotypes

1Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Department of Hematology, Yantai, China2Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Laboratory of Hematology, Yantai, ChinaJunqing Xu1, Baohua Huang2, Xiaoqian Liu1, Yuanfeng Zhang1, Yinghui Liu1, Liming Chen1, Yanyan Luan1, Nannan Li1, Xiaoxia Chu1Poor Prognosis in Acute Myeloid Leukemia Patients with Monozomal Karyotipi Olan Akut Miyeloid Lösemili Hastalarda Kötü Prognoz

📌 3 Key Takeaways

🎯

Objective & Hypothesis:1Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Department of Hematology, Yantai, China2Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Laboratory of Hematology, Yantai, ChinaJunqing Xu1, Baohua Huang2, Xiaoqian Liu1, Yuanfeng Zhang1, Yinghui Liu1, Liming Chen1, Yanyan Luan1, Nannan Li1, Xiaoxia Chu1Poor Prognosis in Acute Myeloid Leukemia Patients with Monozomal Karyotipi Olan Akut Miyeloid Lösemili Hastalarda Kötü Prognoz

📊

Key Findings & Data:1Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Department of Hematology, Yantai, China2Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Laboratory of Hematology, Yantai, ChinaJunqing Xu1, Baohua Huang2, Xiaoqian Liu1, Yuanfeng Zhang1, Yinghui Liu1, Liming Chen1, Yanyan Luan1, Nannan Li1, Xiaoxia Chu1Poor Prognosis in Acute Myeloid Leukemia Patients with Monozomal Karyotipi Olan Akut Miyeloid Lösemili Hastalarda Kötü Prognoz

💡

Conclusion & Impact:1Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Department of Hematology, Yantai, China2Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Laboratory of Hematology, Yantai, ChinaJunqing Xu1, Baohua Huang2, Xiaoqian Liu1, Yuanfeng Zhang1, Yinghui Liu1, Liming Chen1, Yanyan Luan1, Nannan Li1, Xiaoxia Chu1Poor Prognosis in Acute Myeloid Leukemia Patients with Monozomal Karyotipi Olan Akut Miyeloid Lösemili Hastalarda Kötü Prognoz

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

1Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Department of Hematology, Yantai, China2Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Laboratory of Hematology, Yantai, ChinaJunqing Xu1, Baohua Huang2, Xiaoqian Liu1, Yuanfeng Zhang1, Yinghui Liu1, Liming Chen1, Yanyan Luan1, Nannan Li1, Xiaoxia Chu1Poor Prognosis in Acute Myeloid Leukemia Patients with Monozomal Karyotipi Olan Akut Miyeloid Lösemili Hastalarda Kötü Prognoz

Özet

Amaç: Bu çalışmada akut myeloid lösemi (AML) hastalarında monozomal karyotipe (MK) sahip olmanın klinik özellikleri ve prognostik önemini araştırmak hedeflenmiştir. Gereç ve Yöntemler: Retrospektif olarak 498 AML hastasının klinik verileri incelenmiştir. Bu hastalardan 233'ünde (%46,8) anormal karyotip saptanmış olup, bunların da 42'sinde (%8,4) MK ve 70'inde kompleks karyotip (KK) bulunmuştur. Bulgular: Hastalardan MK'ya sahip olanlar daha yaşlı olup (ortanca 62,5 vs. 52 yıl; p=0,003), daha düşük ortanca hemoglobin düzeyine (62,5 vs. 77 g/L; p=0,009) ve daha düşük beyaz küre sayısına (7,0×109/L vs. 11,7×109/L, p=0,008) sahipti. Ünivaryant analizde MK ya da KK'ya sahip olan hastaların diğer hastalara göre toplam sağkalımı daha düşük bulundu. (MK için ortanca sağkalım süresi 7,3 vs. 26,3 ay, p<0,001 ve CK için 14,8 vs. 26,3 ay, p<0,001). Toplam sağkalım için yapılan, multivaryant analizde ise MK ve "National Comprehesnsive Cancer Network" prognostik grubu anlamlı bulunan faktörlerdi. Sonuç: AML'li hastalarda MK kötü prognoza işaret eden bağımsız bir risk faktörüdür.

🔖

Cite This Article

XU, J., HUANG, B., LİU, X., ZHANG, Y., LİU, Y., CHEN, L., LUAN, Y., Lİ, N., CHU, X. (2017). Poor Prognosis in Acute Myeloid Leukemia Patients with Monosomal Karyotypes. Turkish Journal of Hematology, Cilt: 34 - Sayı: 2, 126–130. https://ajindex.com/articles/413078

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (7)

Breems DA, Van Putten WL, De Greef GE, Van Zelderen-Bhola SL, Gerssen- Schoorl KB, Mellink CH, Nieuwint A, Jotterand M, Hagemeijer A, Beverloo HB, Löwenberg B. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol 2008;26:4791-4797.
Kayser S, Zucknick M, Döhner K, Krauter J, Köhne CH, Horst HA, Held G, von Lilienfeld-Toal M, Wilhelm S, Rummel M, Germing U, Götze K, Nachbaur D, Schlegelberger B, Göhring G, Späth D, Morlok C, Teleanu V, Ganser A, Döhner H, Schlenk RF; German-Austrian AML Study Group. Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies. Blood 2012;119:551-558.
Voutiadou G, Papaioannou G, Gaitatzi M, Lalayanni C, Syrigou A, Vadikoliou C, Saloum R, Anagnostopoulos A, Athanasiadou A. Monosomal karyotype in acute myeloid leukemia deŞnes a distinct subgroup within the adverse cytogenetic risk category. Cancer Genet 2013;206:32-36. Schiffer CA. World Health Organization and international prognostic scoring system: the limitations of current classification systems in assessing prognosis and determining appropriate therapy in myelodysplastic syndromes. Semin Hematol 2008;45:3-7.
Slovak ML, Kopecky KJ, Cassileth PA, Harrington DH, Theil KS, Mohamed A, Paietta E, Willman CL, Head DR, Rowe JM, Forman SJ, Appelbaum FR. Karyotypic analysis predicts outcome of preremission and postremisson therapy in adult acute myeloid leukemia: a Southwest Oncology Group/ Eastern Cooperative Oncology Group study. Blood 2000;96:4075-4083.
Medeiros BC, Othus M, Fang M, Roulston D, Appelbaum FR. Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience. Blood 2010;116:2224-2228.
Schlenk RF, Döhner K, Krauter J, Fröhling S, Corbacioglu A, Bullinger L, Habdank M, Späth D, Morgan M, Benner A, Schlegelberger B, Heil G, Ganser A, Döhner H; German-Austrian Acute Myeloid Leukemia Study Group. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008;358:1909-1918.
Radmacher MD, Marcucci G, Ruppert AS, Mrózek K, Whitman SP, Vardiman JW, Paschka P, Vukosavljevic T, Baldus CD, Kolitz JE, Caligiuri MA, Larson RA, Bloomfield CD; Cancer and Leukemia Group B. Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study. Blood 2006;108: