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Journals / Turkish Journal of Hematology / 2009 / Cilt: 26 - Sayı: 3

Hipertrikoz; Hemofagositik lenfohistiositozu olan ve HLH-2004 kemoterapi protokolü uygulanan hastada siklosporine bağlı gelişen olası yan etki

Hypertrichosis: The possible side effect of cyclosporin in an infant with hemophagocytic lymphohistiocytosis receiving HLH-2004 chemotherapy protocol

SİNEM AKGÜL
Yasemin Işıl BALCI
Şule ÜNAL
Ayfer ALİKAŞİFOĞLU
Aytemiz GÜRGEY
Pages
154–156
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Herein, we present a 13- month-old infant, who developed severe hypertrichosis after the administration of HLH-2004 treatment protocol and discuss the various hypotheses regarding the causal relationship between cyclosporine A and hypertrichosis, emphasizing the importance of patient follow up.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hemophagocytic lymphohistiocytosis is a life-threatening condition of severe hyperinflammation that results from an uncontrolled proliferation of activated lymphocytes and histiocytes secreting high amounts of inflammatory cytokines.
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Key Findings & Data:The immediate treatment strategies include immune suppressive therapy such as corticosteriod, etaposide and cyclosporin A.
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Conclusion & Impact:Herein, we present a 13- month-old infant, who developed severe hypertrichosis after the administration of HLH-2004 treatment protocol and discuss the various hypotheses regarding the causal relationship between cyclosporine A and hypertrichosis, emphasizing the importance of patient follow up.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Hipertirikozis · Süt çocuğu · Erkek

Abstract

Hemophagocytic lymphohistiocytosis is a life-threatening condition of severe hyperinflammation that results from an uncontrolled proliferation of activated lymphocytes and histiocytes secreting high amounts of inflammatory cytokines. The immediate treatment strategies include immune suppressive therapy such as corticosteriod, etaposide and cyclosporin A. Herein, we present a 13- month-old infant, who developed severe hypertrichosis after the administration of HLH-2004 treatment protocol and discuss the various hypotheses regarding the causal relationship between cyclosporine A and hypertrichosis, emphasizing the importance of patient follow up.

Özet

Hemofagositik lenfohistiositoz yüksek düzeylerde enflamatuvar sitokin salgılayan, kontrol edilemeyen aktif lenfosit ve histiosit proliferasyonu ile seyreden ağır enflamasyonun görüldüğü hayatı tehdit eden bir hastalıktır. Tedavi stratejileri arasında korikosteroid, etoposid, ve siklosporin gibi immünsupresif tedaviler yer almaktadır. Bu raporda hemofagositik lenfohistiositoz tanısı alan ve HLH-2004 protokolüne uygun tedavi sonrası ağır hipertrikoz gelişen 13 aylık bir hasta anlatılmıştır. Siklosporin A ve hipertrikoz arasındaki nedensel hipotez tartışılmış ve hasta takibinin önemi anlatılmıştır.

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Cite This Article

AKGÜL, S., BALCI, Y. I., ÜNAL, Ş., ALİKAŞİFOĞLU, A., GÜRGEY, A. (2009). Hipertrikoz; Hemofagositik lenfohistiositozu olan ve HLH-2004 kemoterapi protokolü uygulanan hastada siklosporine bağlı gelişen olası yan etki. Turkish Journal of Hematology, Cilt: 26 - Sayı: 3, 154–156. https://ajindex.com/articles/413017

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