This case suggests that activated protein C resistance may be associated with arterial as well as venous thrombotic events and impliesthat resistance to activated protein C should also be considered in the evaluation of young adults with strokes.
📌 3 Key Takeaways
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Objective & Hypothesis:A 27 year old woman presented with recurrent cerebrovascular strokes in the setting of an ill defined auto-immune disease responsive to corticosteroid therapy.
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Key Findings & Data:Her parents and sibling did not demonstrate APC resistance.
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Conclusion & Impact:This case suggests that activated protein C resistance may be associated with arterial as well as venous thrombotic events and impliesthat resistance to activated protein C should also be considered in the evaluation of young adults with strokes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
A 27 year old woman presented with recurrent cerebrovascular strokes in the setting of an ill defined auto-immune disease responsive to corticosteroid therapy. Investigation for a hyperooagulable state revealed activated protein C resistance in the absence of protein C, protein S, or antithrombin III deficiency or anticardiolipin antibodies. Her parents and sibling did not demonstrate APC resistance. This case suggests that activated protein C resistance may be associated with arterial as well as venous thrombotic events and impliesthat resistance to activated protein C should also be considered in the evaluation of young adults with strokes.
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Cite This Article
YOSSEPOWITCH, O., SAFADI, R., RUBINOW, A., CHAJECK-SHAUL, T. (1996). Resistance to activated protein C: Arterial thrombosis associated with autoimmune features. Turkish Journal of Hematology, Cilt: 14 - Sayı: 2, 75–78. https://ajindex.com/articles/412997